Yuxuan Miao

Assistant Professor
Websites
Research Summary
Yuxuan (Phoenix) Miao’s research focuses on understanding how normal and cancerous epithelial tissue adapt to inflammation, with a special interest in dissecting how stem cells residing in these tissues interact with the immune system to maintain normal tissue fitness and achieve cancer immune evasion.
Keywords
Adult Stem Cell, Cancer Immunology, Wound Healing, Tissue Regeneration
Education
  • Rockefeller University, New York, NY, Postdoc Stem cell and cancer biology 08/2020
  • Duke University School of Medicine, Durham, NC, PhD Immunology 06/2015
  • Beijing Institute of Technology, Beijing, China, B.S. Biotechnology 06/2008
Biosciences Graduate Program Association
Awards & Honors
  • 2009 - Duke Chancellor Award Duke University
  • 2015 - Mitchell Meritorious Research Award Duke University
  • 2016 - 2019 Jane Coffin Childs Fellowship Rockefeller University
  • 2019 - 2020 Robertson Therapeutic Development Foundation Award Rockefeller University
  • 2019 - 2023 NCI K99/R00 Pathway to Independence Award Rockefeller University
Publications
  1. Wu J, Hayes BW, Phoenix C, Macias GS, Miao Y, Choi HW, Hughes FM, Todd Purves J, Lee Reinhardt R, Abraham SN. A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections. Nat Immunol. 2020 06; 21(6):671-683. View in: PubMed

  2. Adam RC, Yang H, Ge Y, Infarinato NR, Gur-Cohen S, Miao Y, Wang P, Zhao Y, Lu CP, Kim JE, Ko JY, Paik SS, Gronostajski RM, Kim J, Krueger JG, Zheng D, Fuchs E. NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices. Nat Cell Biol. 2020 06; 22(6):640-650. View in: PubMed

  3. Gur-Cohen S, Yang H, Baksh SC, Miao Y, Levorse J, Kataru RP, Liu X, de la Cruz-Racelis J, Mehrara BJ, Fuchs E. Stem cell-driven lymphatic remodeling coordinates tissue regeneration. Science. 2019 12 06; 366(6470):1218-1225. View in: PubMed

  4. Miao Y, Yang H, Levorse J, Yuan S, Polak L, Sribour M, Singh B, Rosenblum MD, Fuchs E. Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells. Cell. 2019 05 16; 177(5):1172-1186.e14. View in: PubMed

  5. Miao Y, Bist P, Wu J, Zhao Q, Li QJ, Wan Y, Abraham SN. Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium. Cell Host Microbe. 2017 Sep 13; 22(3):330-342.e4. View in: PubMed

  6. Choi HW, Bowen SE, Miao Y, Chan CY, Miao EA, Abrink M, Moeser AJ, Abraham SN. Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules. Immunity. 2016 12 20; 45(6):1258-1269. View in: PubMed

  7. Miao Y, Wu J, Abraham SN. Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex. Immunity. 2016 07 19; 45(1):94-105. View in: PubMed

  8. Abraham SN, Miao Y. The nature of immune responses to urinary tract infections. Nat Rev Immunol. 2015 Oct; 15(10):655-63. View in: PubMed

  9. Miao Y, Li G, Zhang X, Xu H, Abraham SN. A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. Cell. 2015 Jun 04; 161(6):1306-19. View in: PubMed