CCB Students produce substantial bodies of work that lead to high quality, peer-reviewed publications. The menus below highlight papers our students have published in recent years. To access each publication, click on the PMID, to be redirected to PubMed, allowing you access to the abstract, as well as providing options to read the publication.
Wang Y, Wilfahrt D, Jonker P, Lontos K, Cai C, Cameron B, Xie B, Peralta RM, Schoedel ER, Gunn WG, AminiTabrizi R, Shah H, Rivadeneira D, Muir A, Delgoffe GM. Tumour interstitial fluid-enriched phosphoethanolamine suppresses T cell function. Nat Cell Biol 27, 835–846 (2025). https://doi.org/10.1038/s41556-025-01650-9.
Cai L, Hammond NG, Tasdogan A, Alsamraae M, Yang C, Cameron RB, Quan P, Solmonson A, Gu W, Pachnis P, Kaur M, Chang BK, Zhou Q, Hensley CT, Do QN, Martins Nascentes Melo L, Ubellacker JM, Kaushik A, Clare MG, Alcazar IN, Kurylowicz K, Marcuccilli JD, Allies G, Kutritz A, Klode J, Ramesh V, Rogers TJ, Rao AD, Crentsil HE, Li H, Brister F, McDaniel P, Xu X, Evers BM, Zacharias LG, Sudderth J, Xu J, Mathews TP, Oliver D, Minna JD, Waters J, Morrison SJ, Kernstine KH, Faubert B, DeBerardinis RJ. High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in Patients. Cancer Discov. 2025 Apr 2;15(4):702-716. doi: 10.1158/2159-8290.CD-23-1319. PMID: 39960461; PMCID: PMC11962397.
Tumuluru S, Godfrey JK, Cooper A, Yu J, Chen X, MacNabb B, Venkataraman G, Zha Y, Pelzer B, Song JY, Duns G, Sworder B, Raj SS, Bolen CR, Penuel E, Postovalova E, Kotlov N, Bagaev A, Fowler NH, Shouval R, Smith SM, Alizadeh AA, Steidl C, Kline JP. Integrative genomic analysis of DLBCL identifies immune environments associated with bispecific antibody response. Blood. 2025 Jan 27:blood.2024025355. doi: 10.1182/blood.2024025355. PMID: 39869833.
Acero-Bedoya S, Higgs EF, Martinez AC, Tonea R, Gajewski TF. Dendritic cell-intrinsic PTPN22 negatively regulates antitumor immunity and impacts anti-PD-L1 efficacy. Journal for ImmunoTherapy of Cancer. 2024 Oct 26;12:e009588. doi: 10.1136/jitc-2024-009588. PMID: 39461876; PMCID: PMC11529514.
Brenes-Chacon H, Eisner M, Acero-Bedoya S, Ramilo O, Mejias A. Age-specific predictors of disease severity in children with respiratory syncytial virus infection beyond infancy and through the first 5 years of age. Pediatr Allergy Immunol. 2024; 35:e14083. doi:10.1111/pai.14083. PMID: 38363050.
Cai C, Tu J, Najarro J, Zhang R, Fan H, Zhang FQ, Li J, Xie Z, Su R, Dong L, Arellano N, Ciboddo M, Elf SE, Gao X, Chen J, Wu R. NRAS Mutant Dictates AHCYL1-Governed ER Calcium Homeostasis for Melanoma Tumor Growth. Mol Cancer Res. 2024 Apr 2;22(4):386-401. doi: 10.1158/1541-7786.MCR-23-0445. PMID: 38294692; PMCID: PMC10987265.
Hammond NG, Cameron RB, Faubert B. Beyond glucose and Warburg: finding the sweet spot in cancer metabolism models. npj Metab Health Dis 2, 11 (2024). https://doi.org/10.1038/s44324-024-00017-2
Lainé M, Greene ME, Kurleto JD, Grazyna B, Leng T, Huggins RJ, Komm BS, Greene GL. Lasofoxifene as a potential treatment for aromatase inhibitor-resistant ER-positive breast cancer. Breast Cancer Res 26, 95 (2024). https://doi.org/10.1186/s13058-024-01843-4. PMID: 38849889; PMCID: PMC11161925.
Huggins RJ, Greene GL. ERα/PR crosstalk is altered in the context of the ERα Y537S mutation and contributes to endocrine therapy-resistant tumor proliferation. npj Breast Cancer 9, 96 (2023). https://doi.org/10.1038/s41523-023-00601-7. PMID: 38036546; PMCID: PMC10689488.
Jonker PB, Muir A. Metabolic ripple effects - deciphering how lipid metabolism in cancer interfaces with the tumor microenvironment. Dis Model Mech. 2024 Sep 1;17(9):dmm050814. doi: 10.1242/dmm.050814. Epub 2024 Sep 16. PMID: 39284708; PMCID: PMC11423921.
Wolf MM, Madden MZ, Arner EN, Bader JE, Ye X, Vlach L, Tigue ML, Landis MD, Jonker PB, Hatem Z, Steiner KK, Gaines DK, Reinfeld BI, Hathaway ES, Xin F, Tantawy MN, Haake SM, Jonasch E, Muir A, Weiss VL, Beckermann KE, Rathmell WK, Rathmell JC. VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis. J Clin Invest. 2024 Apr 15;134(8):e173934. doi: 10.1172/JCI173934. PMID: 38618956; PMCID: PMC11014672.
Liao R, Hsu JY, Aboelella NS, McKeever JA, Thomas-Toth AT, Koh AS, LaBelle JL. Venetoclax Induces BCL-2-Dependent Treg to TH17 Plasticity to Enhance the Antitumor Efficacy of Anti-PD-1 Checkpoint Blockade. Cancer Immunol Res. 2024 Aug 1;12(8):1074-1089. doi: 10.1158/2326-6066.CIR-23-0344. PMID: 38810242; PMCID: PMC11293981.
Cooper A, Tumuluru S, Kissick K, Venkataraman G, Song JY, Lytle A, Duns G, Yu J, Kotlov N, Bagaev A, Hodkinson B, Srinivasan S, Smith SM, Scott DW, Steidl C, Godfrey JK, Kline J. CD5 Gene Signature Identifies Diffuse Large B-Cell Lymphomas Sensitive to Bruton's Tyrosine Kinase Inhibition. J Clin Oncol. 2024 Feb 1;42(4):467-480. doi: 10.1200/JCO.23.01574. Epub 2023 Dec 11. PMID: 38079587.
Chen X, Yu J, Venkataraman G, Smith SM, Chen M, Cooper A, Tumuluru S, Brody JD, Godfrey J, Kline J. T-cell States, Repertoire, and Function in Classical Hodgkin Lymphoma Revealed through Single-Cell Analyses. Cancer Immunol Res. 2024 Mar 4;12(3):296-307. doi: 10.1158/2326-6066.CIR-23-0547. PMID: 38240659.
Verghese M, Freeman JQ, Connor BW, Hazra A, Fisher AR, Rosenblatt AE. Perspectives on Full-Body Skin Examinations Among Sexual and Gender Minority Patients. JAMA Dermatol. 2024 Mar 1;160(3):361-363. doi: 10.1001/jamadermatol.2023.5821. PMID: 38294799; PMCID: PMC10831626.
Yang Z, Verghese M, Yang S, Shah P, He YY. The m6A reader YTHDC2 regulates UVB-induced DNA damage repair and histone modification. Photochem Photobiol. 2024 Jul-Aug;100(4):1031-1040. doi: 10.1111/php.13904. Epub 2024 Jan 8. PMID: 38190286; PMCID: PMC11228125.
Binder AK, Peecher DL, Qvigstad AJ, Gutierrez SD, Magaña J, Banks DB, Korach KS. Differential Strain-dependent Ovarian and Metabolic Responses in a Mouse Model of PCOS. Endocrinology. 2023 Feb 11;164(4):bqad024. doi: 10.1210/endocr/bqad024. PMID: 36718579; PMCID: PMC10208753.
Huggins RJ, Hosfield D, Ishag-Osman A, Lee K, Ton-That E, Greene GL. Evaluating steroid hormone receptor interactions using the live-cell NanoBRET proximity assay. bioRxiv : the preprint server for biology, 2023.07.25.550078. https://doi.org/10.1101/2023.07.25.550078. PMID: 37546915; PMCID: PMC10402027.
Godfrey J, Chen X, Sunseri N, Cooper A, Yu J, Varlamova A, Zarubin D, Popov Y, Jacobson C, Postovalova E, Xiang Z, Nomie K, Bagaev A, Venkataraman G, Zha Y, Tumuluru S, Smith SM, Kline JP. TIGIT is a key inhibitory checkpoint receptor in lymphoma. J Immunother Cancer. 2023 Jun;11(6):e006582. doi: 10.1136/jitc-2022-006582. PMID: 37364933; PMCID: PMC10410806.
Canaria DA, Clare MG, Yan B, Campbell CB, Ismaio ZA, Anderson NL, Park S, Dent AL, Kazemian M, Olson MR.Front Immunol. 2022 Nov 1;13:1032618. doi: 10.3389/fimmu.2022.1032618. eCollection 2022. PMID: 36389679
Ibarra J, Elbanna YA, Kurylowicz K, Ciboddo M, Greenbaum HS, Arellano NS, Rodriguez D, Evers M, Bock-Hughes A, Liu C, Smith Q, Lutze J, Baumeister J, Kalmer M, Olschok K, Nicholson B, Silva D, Maxwell L, Dowgielewicz J, Rumi E, Pietra D, Casetti IC, Catricala S, Koschmieder S, Gurbuxani S, Schneider RK, Oakes SA, Elf SE. Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms. Blood Cancer Discov. 2022 Jul 6;3(4):298-315. doi: 10.1158/2643-3230.BCD-21-0144. PMID: 35405004; PMCID: PMC9338758.
Speltz TE, Qiao Z, Swenson CS, Shangguan X, Coukos JS, Lee CW, Thomas DM, Santana J, Fanning SW, Greene GL, Moellering RE. Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Nat Biotechnol. 2023 Apr;41(4):541-551. doi: 10.1038/s41587-022-01504-x. Epub 2022 Oct 27. PMID: 36302987; PMCID: PMC10392954.
MacNabb BW, Tumuluru S, Chen X, Godfrey J, Kasal DN, Yu J, Jongsma MLM, Spaapen RM, Kline DE, Kline J. Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing. Immunity. 2022 Jun 14;55(6):982-997.e8. doi: 10.1016/j.immuni.2022.04.016. Epub 2022 May 25. Erratum in: Immunity. 2022 Nov 8;55(11):2206-2208. doi: 10.1016/j.immuni.2022.09.015. PMID: 35617964; PMCID: PMC9883788.
Zhang X, Trendowski MR, Wilkinson E, Shahbazi M, Dinh PC, Shuey MM; Regeneron Genetics Center; Feldman DR, Hamilton RJ, Vaughn DJ, Fung C, Kollmannsberger C, Huddart R, Martin NE, Sanchez VA, Frisina RD, Einhorn LH, Cox NJ, Travis LB, Dolan ME. Pharmacogenomics of cisplatin-induced neurotoxicities: Hearing loss, tinnitus, and peripheral sensory neuropathy. Cancer Med. 2022 Jul;11(14):2801-2816. doi: 10.1002/cam4.4644. Epub 2022 Mar 23. PMID: 35322580
Verghese M, Wilkinson E, He YY. Role of RNA modifications in carcinogenesis and carcinogen damage response. Mol Carcinog. 2023 Jan;62(1):24-37. doi: 10.1002/mc.23418. Epub 2022 May 13. PMID: 35560957
Park G, Cui YH, Yang S, Sun M, Wilkinson E, Li H, Zhang YB, Chen J, Bissonnette M, Lin W, He YY. Moderate Low UVB Irradiation Modulates Tumor-associated Macrophages and Dendritic Cells and Promotes Antitumor Immunity in Tumor-bearing Mice. Photochem Photobiol. 2022 Jul 29. doi: 10.1111/php.13684. Epub ahead of print. PMID: 35962531
Cui, Y.-H*.; Wilkinson, E.*; Peterson, J.; He, Y.-Y. ALKBH4 Stabilization Is Required for Arsenic-Induced 6mA DNA Methylation Inhibition, Keratinocyte Malignant Transformation, and Tumorigenicity. Water 2022, 14, 3595. https://doi.org/10.3390/w14223595
Verghese M, Wilkinson E, He YY. Recent advances in RNA m6A modification in solid tumors and tumor immunity. Under Review in Epigenetics in Oncology. December 2022.
Fowler FC, Chen BR, Zolnerowich N, Wu W, Pavani R, Paiano J, Peart C, Chen Z, Nussenzweig A, Sleckman BP, Tyler JK. DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cells. Elife. 2022 May 16;11:e74700. doi: 10.7554/eLife.74700. PMID: 35575473
Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, Zong D, Wong N, Noriega S, Nathan WJ, Matos-Rodrigues G, Chari R, Kruhlak MJ, Livak F, Ward M, Caldecott K, Di Stefano B, Nussenzweig A. Active DNA demethylation promotes cell fate specification and the DNA damage response. Science. 2022 Dec 2;378(6623):983-989. doi: 10.1126/science.add9838. Epub 2022 Dec 1. PMID: 36454826
Liu Z, Busscher BM, Storl-Desmond M, Xiao TS. Mechanisms of Gasdermin Recognition by Proteases. J Mol Biol. 2022 Feb 28;434(4):167274. doi: 10.1016/j.jmb.2021.167274. Epub 2021 Sep 29. PMID: 34599940
O'Neill WQ, Xie X, Gui S, Yu H, Davenport J, Cartwright T, Storl-Desmond M, Ryu E, Chan ER, Cao S, Fu P, Teknos TN, Pan Q. Repositioning Fenofibrate to Reactivate p53 and Reprogram the Tumor-Immune Microenvironment in HPV+ Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2022 Jan 7;14(2):282. doi: 10.3390/cancers14020282. PMID: 35053444
Kiemen AL, Braxton AM, Grahn MP, Han KS, Babu JM, Reichel R, Jiang AC, Kim B, Hsu J, Amoa F, Reddy S, Hong SM, Cornish TC, Thompson ED, Huang P, Wood LD, Hruban RH, Wirtz D, Wu PH. CODA: quantitative 3D reconstruction of large tissues at cellular resolution. Nat Methods. 2022 Nov;19(11):1490-1499. doi: 10.1038/s41592-022-01650-9. Epub 2022 Oct 24. PMID: 36280719
Hsu JY, Seligson ND, Hays JL, Miles WO, Chen JL. Clinical Utility of CDK4/6 Inhibitors in Sarcoma: Successes and Future Challenges. JCO Precis Oncol. 2022 Feb;6:e2100211. doi: 10.1200/PO.21.00211. PMID: 35108033
Ning Y, Zhou IY, Roberts JD Jr, Rotile NJ, Akam E, Barrett SC, Sojoodi M, Barr MN, Punshon T, Pantazopoulos P, Drescher HK, Jackson BP, Tanabe KK, Caravan P. Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatment. Sci Transl Med. 2022 Sep 21;14(663):eabq6297. doi: 10.1126/scitranslmed.abq6297. Epub 2022 Sep 21. PMID: 36130015
Ning Y, Zhou IY, Rotile NJ, Pantazopoulos P, Wang H, Barrett SC, Sojoodi M, Tanabe KK, Caravan P. Dual Hydrazine-Equipped Turn-On Manganese-Based Probes for Magnetic Resonance Imaging of Liver Fibrogenesis. J Am Chem Soc. 2022 Sep 14;144(36):16553-16558. doi: 10.1021/jacs.2c06231. Epub 2022 Aug 23. PMID: 35998740
Li DK, Chaudhari SN, Lee Y, Sojoodi M, Adhikari AA, Zukerberg L, Shroff S, Barrett SC, Tanabe K, Chung RT, Devlin AS. Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury. Sci Adv. 2022 Aug 26;8(34):eabo2794. doi: 10.1126/sciadv.abo2794. Epub 2022 Aug 26. PMID: 36026454
Crouchet E, Li S, Sojoodi M, Bandiera S, Fujiwara N, El Saghire H, Zhu S, Qian T, Rasha FA, Del Zompo F, Barrett SC, Schaeffer E, Oudot MA, Ponsolles C, Durand SC, Ghoshal S, Arora G, Giannone F, Chung RT, Slovic N, Van Renne N, Felli E, Pessaux P, Lupberger J, Pochet N, Schuster C, Tanabe KK, Hoshida Y, Fuchs BC, Baumert TF. Hepatocellular carcinoma chemoprevention by targeting the angiotensin-converting enzyme and EGFR transactivation. JCI Insight. 2022 Jul 8;7(13):e159254. doi: 10.1172/jci.insight.159254. PMID: 35801591
Sojoodi M, Erstad DJ, Barrett SC, Salloum S, Zhu S, Qian T, Colon S, Gale EM, Jordan VC, Wang Y, Li S, Ataeinia B, Jalilifiroozinezhad S, Lanuti M, Zukerberg L, Caravan P, Hoshida Y, Chung RT, Bhave G, Lauer GM, Fuchs BC, Tanabe KK. Peroxidasin Deficiency Re-programs Macrophages Toward Pro-fibrolysis Function and Promotes Collagen Resolution in Liver. Cell Mol Gastroenterol Hepatol. 2022;13(5):1483-1509. doi: 10.1016/j.jcmgh.2022.01.015. Epub 2022 Jan 28. PMID: 35093588
Canaria DA, Yan B, Clare MG, Zhang Z, Taylor GA, Boone DL, Kazemian M, Olson MR.J Immunol. 2021 Sep 1;207(5):1265-1274. doi: 10.4049/jimmunol.2100165. Epub 2021 Aug 4. PMID: 34348976
Wilkinson E, Cui YH, He YY. Context-Dependent Roles of RNA Modifications in Stress Responses and Diseases. Int J Mol Sci. 2021 Feb 16;22(4):1949. doi: 10.3390/ijms22041949. PMID: 33669361
Paiano J, Zolnerowich N, Wu W, Pavani R, Wang C, Li H, Zheng L, Shen B, Sleckman BP, Chen BR, Nussenzweig A. Role of 53BP1 in end protection and DNA synthesis at DNA breaks. Genes Dev. 2021 Oct 1;35(19-20):1356-1367. doi: 10.1101/gad.348667.121. Epub 2021 Sep 9. PMID: 34503990
Yu Z, Ku AF, Anglin JL, Sharma R, Ucisik MN, Faver JC, Li F, Nyshadham P, Simmons N, Sharma KL, Nagarajan S, Riehle K, Kaur G, Sankaran B, Storl-Desmond M, Palmer SS, Young DW, Kim C, Matzuk MM. Discovery and characterization of bromodomain 2-specific inhibitors of BRDT. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2021102118. doi: 10.1073/pnas.2021102118. PMID: 33637650
Rosenberg, J, Cao, G, Borja-Prieto, F, Huang, J. (2020). Lattice Light-Sheet Microscopy Multi-Dimensional Analyses (LaMDA) of T-Cell Receptor Dynamics Predict T-Cell Signaling States. Cell Systems, 433-444. PMID: 32437685
Applebaum MA, Barr EK, Karpus J, West-Szymanski DC, Olivia M, Sokol EA, Zhang S, Zhang Z, Zhang W, Chlenski A, Salwen HR, Wilkinson E. (2020). 5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma. Clin Cancer Res. 2020 Mar 15; 26(6): 1309-1317. PMID: 31852832
Rosenberg, J., Huang J. Visualizing Surface T-Cell Receptor Dynamics Four-Dimensionally Using Lattice Light-Sheet Microscopy. JoVE. 2020 Jan 30;(155). PMID: 32065118
Cao JZ, Liu H, Wickrema A, Godley LA. HIF-1 Directly induces TET3 Expression To Enhance 5-hmC Density And Induce Erythroid Gene Expression In Hypoxia. Blood Advances. 2020 Jul 14;4(13):3053-3062. PMID: 32634239
Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCT. MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome. Cell Chem Biol. 2020 May 21;27(5):538-550.e7. PMID: 32101699.
Betori RC, Liu Y, Mishra RK, Cohen SB, Kron SJ, Scheidt KA. Targeted Covalent Inhibition of Telomerase. ACS Chem Biol. 2020 Mar 20; 15(3): 706-707. PMID: 32017522
Brinkman JA, Liu Y, Kron SJ. Small-Molecule Drug Repurposing To Target DNA Damage Repair and Response Pathways. Semin Cancer Biol. 2020 Feb 27; 30046-8. PMID: 32113999
Tiwari P, radlank A, Cui C, hochoenfelt KQ, Zhou G, Xu Y, Khramtsova G, Olopade F, Shah AM, Khan SA, Rosner MR, Becker L. Metabolically activated mammary adipose tissue macrophages link obesity to triple-negative breast cancer. J. Exp. Med. 2019 Jun 3; 216(6): 1345-1358. PMID: 31053611
Di Z, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Czyz D, Hu R, Ye Z, He M, Zheng GY, Shuman H, Ding J, Dai L, Ren B, Roeder RG, Becker L, Zhao, Y. Metabolic regulation of gene expression by histone lactylation. Nature. 2019 Oct; 574(7779): 575-580. PMID: 31645732
Trendowski MR, El Charif O, Ratain MJ, Monahan P, Mu Z, Wheeler HE, Dinh Jr PC, Feldman DR, Ardeshir-Rouhani-Fard S, Hamilton RJ, Vaughn DJ, Fung C, Kollmannsberger C, Mushiroda T, Kubo M, Hannigan R, Strathmann F, Einhorn LH, Fossa SD, Travis LB, Dolan ME. Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy. Clin Cancer Res. 2019 Oct 1; 25(19): 5913-5924. PMID: 31296530
El Charif O, Mapes B, Trendowski MR, Wheeler HE, Wing C, Dinh Jr PC, Frisina RD, Feldman DR, Hamilton RJ, Vaughn DJ, Fung C, Kollmannsberger C, Mushiroda T, Michiaki Kubo M, Gamazon ER, Cox NJ, Huddart R, Ardeshir-Rouhani-Fard S, Monahan P, Fossa SD, Einhorn LH, Travis LB, Dolan ME. Clinical and genome-wide analysis of cisplatin-induced tinnitus implicates novel ototoxic mechanisms. Clin Cancer Res. 2019 Jul 1; 25(13): 4104-4116. PMID: 30952644
Trendowski MR, El Charif O, Dinh Jr. PC, Travis LB, and Dolan ME. Genetic and modifiable risk factors contributing to cisplatin-induced toxicities. Clin Cancer Res. 2019 Feb 15; 25(4): 1147-1155. PMID: 30305294
Chlenski A, Park C, Dobratic M, Salwen HR, Budke B, Hyun-Park J, Miller R, Applebaum MA, Wilkinson E, Nakamura Y, Connell PP, Cohn SL. Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma. Mol Cancer Ther. 2019 Mar; 18(3): 507-516. PMID: 30674566
Yuan TL, Amzallag A, Bagni R, Yi M, Afghani S, Burgan W, Fer N, Garvey L, Powell K, Smith B, Waters A, Drubin D, Thomson T, Liao R, Lee CS, Fellmann C, Stephens R, Luo J, Lowe S, Benes CH, McCormick F. Differential Effector Engagement by Oncogenic KRAS. Cell Reports. 2019 Feb 13; 22(7): 1889-1902. PMID: 29444439
Sulahian R, Kwon JJ, Walsh KH, Pailler E, Bosse TL, Thaker M, Almanza D, Dempster JM, Pan J, Piccioni F, Dumont N, Gonzalez A, Rennhack J, Nabet B, Bchman JA, Goodale A, Lee Y, Bagul M, Liao R, Navarro A, Yuan TL, Ng R, Raghavan S, Gray NS, Tsherniak A, Vazquez F, Root D, Firestone AJ, Settleman J, Hahn W, Aguirre AJ. Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers. Cell Reports 29.1. 2019 Oct 1;29(1): 118-134. PMID: 31577942
Jeong JJ, Gu X, Nie J, Sundaravel S, Liu H, Kuo WL, Bhagat TD, Pradhan K, Cao J, Nischal S, McGraw KL, Bhattacharyya S, Bishop MR, Artz A, Thirman MJ, Moliterno A, Ji P, Levine RL, Godley LA, Steidl U, Bieker J, List AF, Sauntharajah Y, He C, Verma A, and Wickrema A. Cytokine regulated phosphorylation and activation of TET2 by JAK2 in hematopoiesis. Cancer Discov. 2019 Jun; 9(6): 778-795. PMID: 30944118
Moshfegh CM, Collins CW, Gunda V, Vasanthakumar A, Cao JZ, Singh PK, Godley LA, and Case AJ. Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes. Redox Biol. 2019 Oct; 27:101141. PMID: 30819616
Ludwig L. M, Maxcy K, LaBelle J. Flow Cytometry-Based Detection and Analysis of BCL-2 Family Proteins and Mitochondrial Outer Membrane Permeabilization (MOMP). Methods Mol Biol. 2019; 1877:77-91. PMID: 30535999
Fessler J, Matson V, Gajewski TF. Exploring The Emerging Role of the Microbiome in Cancer Immunotherapy. J Immunother Cancer. 2019 Apr 17; 7(1):108. PMID: 30995949.
Edimova EV, Appelbe OK, Ricco N, Lee SSY, Liu Y, Wolfgeher DJ, Collins TN, Flor AC, Ramamurthy A, Warrington S, Bindokas VP, Kron SJ. O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors. Mol Cancer Res. 2019 Jun; 17(6):1338-50. PMID: 30885991.
Liu Y, Efimova EV, Ramamurthy A, Kron SJ. Redependent Functions of DNA-PKcs Protect Irradiated Cells From Mitotic Slippage and Accelerated Senescence. J Cell Sci. 2019 Jun 1; 132(13). PMID: 31189537.
Smith AG, Macleod KF. Autophagy, Cancer Stem Cells and Drug Resistance. J Pathol. 2019 Apr; 247(5); 708-18. PMID: 30570140.
Godfrey J, Tumuluru S, Bao R, Leukam M, Venkataraman G, Phillip J, Fitzpatrick C, McElherne J, MacNabb BW, Orlowski R, Smith SM, Kline J. PD-L1 Gene Alterations Identify A Subset of Diffuse Large B-Cell Lymphoma Harboring a T-Cell Inflamed Phenotype. Blood. 2019 May 23. 133(21); 2279- 90. PMID:30910787.
Thekkan S, Jani M, Cui C, Dan K, Zhou G, Becker L, Krishnan Y. A DNA-based fluorescent reporter maps HOCl production in the maturing phagosome. Nat. Chem. Bio. 2019 Dec; 15(12):1165-72. PMID: 30531966
Reardon, CA, Lingaraju A, Schoenfelt KQ, Zhou G, Cui C, Babenko I, Becker L. Obesity and Insulin Resistance Promote Atherosclerosis Through An IFNgamma-regulated Macrophage Protein Network. Cell Report. 2018 Jun 5; 23(10): 3021-3030. PMID: 29874587
Rosenberg J, Huang J. CD8+ T Cells and NK Cells: Parallel and Complementary Soldiers of Immunotherapy. Current Opinion in Chemical Engineering. 2018 Mar; 19: 9-20. PMID: 29623254
Gamazon ER, Trendowski MR, Wen Y, Wing C, Delaney SM, Huh W, Wong S, Cox NJ, Dolan ME. Gene and MicroRNA Perturbations of Cellular Response to Pemetrexed Implicate Biological Networks and Enable Imputation of Response in Lung Adenocarcinoma. Sci Rep. 2018 Jan 15; 8(1):733. PMID: 29335598
Kathayat, RS, Cao Y, Elvira PD, Sandoz PA, Zaballa ME, Springer MZ, Drake LE, Macleod KF, van der Goot FG, Dickinson BC. Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes. Nat Commun 9. 2018 Jan 23; 9(1): 334. PMID: 29362370
Ling A, Gruener RF, Fessler J, Huang R S. More than Fishing for a Cure: The Promises and Pitfalls of High Throughput Cancer Cell Line Screens. Pharmacol Ther. 2018 Nov; 191: 178-189. PMID: 29953899.
Emmanuel AO, Arnovitz S, Haghi L, Mathur PS, Mondal S, Quandt J, Okoreeh MK, Maienschein-Cline M, Khazaie K, Dose M, Gounari F. TCF-1 and HEB Cooperate To Establish The Epigenetic And Transcription Profiles of CD4+ CD8+ Thymocytes. Nat Immunol. 2018 Dec. 19(12);1366-78. PMID: 30420627.
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