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Yu-Ying He, PhD

  • Professor of Medicine
    Committee on Cancer Biology
    Committee on Molecular Medicine
  • Research and Scholarly Interests: Arsenic, Autophagy, DNA damage, DNA Methylation, Epigenetics, m6A, Melanoma, Nucleotide Excision Repair, Photobiology, RNA modification, Skin Cancer, Squamous Cell Carcinoma, Ultraviolet radiation, UV
  • Websites: He Group, He Lab, Research Network Profile
  • Contact: yyhe@uchicago.edu
  • Graduate Program: Cancer Biology

Our research addresses the fundamental questions: how normal cells respond to environmental carcinogens and evolve into cancerous cells. In particular, our group focuses on the role of epitranscriptomics, epigenetics, and autophagy in regulating genomic integrity and cellular homeostasis and to investigate their impact on cancer development and therapeutic resistance, with an emphasis on skin cancer including squamous cancer and melanoma. Our long-term goal is to identify previously unrecognized, therapeutically accessible molecular regulatory networks that predict susceptibility to skin cancer, and improve our ability to prevent and treat these cancers.