Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis. Nat Commun. 2021 04 12; 12(1):2183. View in: PubMed
Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing. Autophagy. 2021 09; 17(9):2128-2143. View in: PubMed
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat Commun. 2019 06 25; 10(1):2782. View in: PubMed
The Role of Dynamic m6 A RNA Methylation in Photobiology. Photochem Photobiol. 2019 01; 95(1):95-104. View in: PubMed
Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair. Nucleic Acids Res. 2018 06 01; 46(10):5050-5060. View in: PubMed
Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism. BMC Cancer. 2018 03 27; 18(1):330. View in: PubMed
Regulation of XPC deubiquitination by USP11 in repair of UV-induced DNA damage. Oncotarget. 2017 Nov 14; 8(57):96522-96535. View in: PubMed
Epidermal SIRT1 regulates inflammation, cell migration, and wound healing. Sci Rep. 2017 10 26; 7(1):14110. View in: PubMed
IL-17A induces heterogeneous macrophages, and it does not alter the effects of lipopolysaccharides on macrophage activation in the skin of mice. Sci Rep. 2017 09 29; 7(1):12473. View in: PubMed
Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis. Autophagy. 2017; 13(12):2086-2103. View in: PubMed
Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation. J Biol Chem. 2017 09 08; 292(36):14786-14795. View in: PubMed
The Autophagy Receptor Adaptor p62 is Up-regulated by UVA Radiation in Melanocytes and in Melanoma Cells. Photochem Photobiol. 2018 05; 94(3):432-437. View in: PubMed
Mechanisms and prevention of UV-induced melanoma. Photodermatol Photoimmunol Photomed. 2018 Jan; 34(1):13-24. View in: PubMed
Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer. Molecules. 2017 Jan 24; 22(2). View in: PubMed
NF-?B Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance. J Biol Chem. 2017 02 24; 292(8):3379-3388. View in: PubMed
Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival. Genes Dis. 2016 Mar; 3(1):82-87. View in: PubMed
Autophagy in UV Damage Response. Photochem Photobiol. 2017 07; 93(4):943-955. View in: PubMed
Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes. Photochem Photobiol. 2017 01; 93(1):375-381. View in: PubMed
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. View in: PubMed
Autophagy positively regulates DNA damage recognition by nucleotide excision repair. Autophagy. 2016; 12(2):357-68. View in: PubMed
Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin. J Invest Dermatol. 2015 Oct; 135(10):2492-2501. View in: PubMed
Ultraviolet B Inhibits Skin Wound Healing by Affecting Focal Adhesion Dynamics. Photochem Photobiol. 2015 Jul-Aug; 91(4):909-16. View in: PubMed
Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation. Genes Dis. 2014 Dec 01; 1(2):188-198. View in: PubMed
Molecular regulation of UV-induced DNA repair. Photochem Photobiol. 2015 Mar-Apr; 91(2):254-64. View in: PubMed
Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge. J Allergy Clin Immunol. 2015 Apr; 135(4):936-945.e4. View in: PubMed
Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells. J Biol Chem. 2014 Dec 26; 289(52):35806-14. View in: PubMed
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer. Cancer Res. 2014 Oct 15; 74(20):5925-33. View in: PubMed
Autophagy deficiency stabilizes TWIST1 to promote epithelial-mesenchymal transition. Autophagy. 2014 Oct 01; 10(10):1864-5. View in: PubMed
Effect of immunosuppressants tacrolimus and mycophenolate mofetil on the keratinocyte UVB response. Photochem Photobiol. 2015 Jan-Feb; 91(1):242-7. View in: PubMed
Regulation of cell proliferation and migration by p62 through stabilization of Twist1. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9241-6. View in: PubMed
Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin. Exp Dermatol. 2014 Mar; 23(3):207-9. View in: PubMed
Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy. Front Oncol. 2013; 3:175. View in: PubMed
Autophagy controls p38 activation to promote cell survival under genotoxic stress. J Biol Chem. 2013 Jan 18; 288(3):1603-11. View in: PubMed
Suppression of PTEN transcription by UVA. J Biochem Mol Toxicol. 2013 Feb; 27(2):184-91. View in: PubMed
Deregulation of XPC and CypA by cyclosporin A: an immunosuppression-independent mechanism of skin carcinogenesis. Cancer Prev Res (Phila). 2012 Sep; 5(9):1155-62. View in: PubMed
Nrf1 CNC-bZIP protein promotes cell survival and nucleotide excision repair through maintaining glutathione homeostasis. J Biol Chem. 2012 May 25; 287(22):18788-95. View in: PubMed
PTEN in DNA damage repair. Cancer Lett. 2012 Jun 28; 319(2):125-129. View in: PubMed
PTEN positively regulates UVB-induced DNA damage repair. Cancer Res. 2011 Aug 01; 71(15):5287-95. View in: PubMed
Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. J Biol Chem. 2011 Jul 01; 286(26):22825-32. View in: PubMed
UVA induces lesions resembling seborrheic keratoses in mice with keratinocyte-specific PTEN downregulation. J Invest Dermatol. 2011 Jul; 131(7):1583-6. View in: PubMed
C/EBPa expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPa confers susceptibility to UVB-induced skin squamous cell carcinomas. J Invest Dermatol. 2011 Jun; 131(6):1339-46. View in: PubMed
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22623-8. View in: PubMed
Recent advances in the prevention and treatment of skin cancer using photodynamic therapy. Expert Rev Anticancer Ther. 2010 Nov; 10(11):1797-809. View in: PubMed
UVB-Induced p21 degradation promotes apoptosis of human keratinocytes. Photochem Photobiol Sci. 2010 Dec; 9(12):1640-8. View in: PubMed
Real-time visualization of photochemically induced fluorescence of 8-halogenated quinolones: lomefloxacin, clinafloxacin and Bay3118 in live human HaCaT keratinocytes. Photochem Photobiol. 2010 Jul-Aug; 86(4):792-7. View in: PubMed
Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis. J Biol Chem. 2010 Apr 09; 285(15):11369-77. View in: PubMed
Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles. Toxicol Appl Pharmacol. 2009 Dec 01; 241(2):163-72. View in: PubMed
PTEN: new insights into its regulation and function in skin cancer. J Invest Dermatol. 2009 Sep; 129(9):2109-12. View in: PubMed
Difference in phototoxicity of cyclodextrin complexed fullerene [(gamma-CyD)2/C60] and its aggregated derivatives toward human lens epithelial cells. Chem Res Toxicol. 2009 Apr; 22(4):660-7. View in: PubMed
Requirement for metalloproteinase-dependent ERK and AKT activation in UVB-induced G1-S cell cycle progression of human keratinocytes. Photochem Photobiol. 2009 Jul-Aug; 85(4):997-1003. View in: PubMed