Nickolai Dulin

Research Summary
Dr. Dulin’s laboratory investigates the signaling mechanisms of TGF-beta-induced myofibroblast differentiation as related to pathogenesis of pulmonary fibrosis, using cell culture and animal models of the disease. His studies have described the critical role for serum response factor (SRF) in myofibroblast differentiation and pulmonary fibrosis, as well as the control of this pathway by actin and microtubule dynamics. The other direction of Dr. Dulin research relates to the basic studies on the biological function of the regulators of G protein signaling (RGS) proteins, focusing on RGS3 member of the family. His group has shown that RGS3 regulates the signaling mediated by heterotrimeric Gi and Gq proteins, as well as non-canonically of TGF-beta signaling. Together with Dr. Anne Sperling, they established the role of RGS3 in control of T cell migration and T cell – mediated inflammation, using knock-down and knockout approaches. His current studies focus on the function of endogenous RGS3 as related to cancer cell growth, migration and EMT. Dr. Dulin's NIH Commons ID is NDULIN
Biosciences Graduate Program Association
Publications
  1. Reed EB, Ard S, La J, Park CY, Culligan L, Fredberg JJ, Smolyaninova LV, Orlov SN, Chen B, Guzy R, Mutlu GM, Dulin NO. Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling. Respir Res. 2019 Jul 29; 20(1):168. View in: PubMed

  2. Dulin NO, Smolyaninova LV, Orlov SN. Control of lung myofibroblast transformation by monovalent ion transporters. Curr Top Membr. 2019; 83:15-43. View in: PubMed

  3. Hamanaka RB, O'Leary EM, Witt LJ, Tian Y, Gökalp GA, Meliton AY, Dulin NO, Mutlu GM. Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts. Am J Respir Cell Mol Biol. 2019 Nov; 61(5):597-606. View in: PubMed

  4. Ard S, Reed EB, Smolyaninova LV, Orlov SN, Mutlu GM, Guzy RD, Dulin NO. Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-ß. Am J Respir Cell Mol Biol. 2019 Mar; 60(3):367-369. View in: PubMed

  5. Duan FF, Barron G, Meliton A, Mutlu GM, Dulin NO, Schuger L. P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-ß1, -ß2, and -ß3 Translation. Am J Respir Cell Mol Biol. 2019 02; 60(2):221-231. View in: PubMed

  6. Koo HY, El-Baz LM, House S, Cilvik SN, Dorry SJ, Shoukry NM, Salem ML, Hafez HS, Dulin NO, Ornitz DM, Guzy RD. Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation. J Pathol. 2018 09; 246(1):54-66. View in: PubMed

  7. Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA, Benovic JL, An SS, Dulin NO, Penn RB. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines. FASEB J. 2018 02; 32(2):862-874. View in: PubMed

  8. Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM. Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 05; 58(5):585-593. View in: PubMed

  9. Orlov SN, La J, Smolyaninova LV, Dulin NO. Na+,K+-ATPase as a Target for Treatment of Tissue Fibrosis. Curr Med Chem. 2019; 26(3):564-575. View in: PubMed

  10. Sandbo N, Smolyaninova LV, Orlov SN, Dulin NO. Control of Myofibroblast Differentiation and Function by Cytoskeletal Signaling. Biochemistry (Mosc). 2016 Dec; 81(13):1698-1708. View in: PubMed

  11. La J, Reed E, Chan L, Smolyaninova LV, Akomova OA, Mutlu GM, Orlov SN, Dulin NO. Downregulation of TGF-ß Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase. PLoS One. 2016; 11(12):e0168363. View in: PubMed

  12. Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM. Transforming Growth Factor (TGF)-ß Promotes de Novo Serine Synthesis for Collagen Production. J Biol Chem. 2016 12 30; 291(53):27239-27251. View in: PubMed

  13. Bindu S, Pillai VB, Kanwal A, Samant S, Mutlu GM, Verdin E, Dulin N, Gupta MP. SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage. Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L68-L78. View in: PubMed

  14. Kapilevich LV, Kironenko TA, Zaharova AN, Kotelevtsev YV, Dulin NO, Orlov SN. Skeletal muscle as an endocrine organ: Role of [Na+]i/[K+]i-mediated excitation-transcription coupling. Genes Dis. 2015 Dec; 2(4):328-336. View in: PubMed

  15. La J, Reed EB, Koltsova S, Akimova O, Hamanaka RB, Mutlu GM, Orlov SN, Dulin NO. Regulation of myofibroblast differentiation by cardiac glycosides. Am J Physiol Lung Cell Mol Physiol. 2016 05 01; 310(9):L815-23. View in: PubMed

  16. Orlov SN, Koltsova SV, Kapilevich LV, Gusakova SV, Dulin NO. NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension. Genes Dis. 2015 Jun; 2(2):186-196. View in: PubMed

  17. Akimova OA, Tverskoi AM, Smolyaninova LV, Mongin AA, Lopina OD, La J, Dulin NO, Orlov SN. Critical role of the a1-Na(+), K(+)-ATPase subunit in insensitivity of rodent cells to cytotoxic action of ouabain. Apoptosis. 2015 Sep; 20(9):1200-10. View in: PubMed

  18. Wu C, Huang RT, Kuo CH, Kumar S, Kim CW, Lin YC, Chen YJ, Birukova A, Birukov KG, Dulin NO, Civelek M, Lusis AJ, Loyer X, Tedgui A, Dai G, Jo H, Fang Y. Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces. Circ Res. 2015 Jul 31; 117(4):e41-e53. View in: PubMed

  19. Bernau K, Ngam C, Torr EE, Acton B, Kach J, Dulin NO, Sandbo N. Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis. Respir Res. 2015 Mar 27; 16:45. View in: PubMed

  20. Mayorova T, Kosevich I, Dulin N, Savina E, Kraus Y. Organizer regions in marine colonial hydrozoans. Zoology (Jena). 2015 Apr; 118(2):89-101. View in: PubMed

  21. Orlov SN, Koltsova SV, Kapilevich LV, Dulin NO, Gusakova SV. Cation-chloride cotransporters: regulation, physiological significance, and role in pathogenesis of arterial hypertension. Biochemistry (Mosc). 2014 Dec; 79(13):1546-61. View in: PubMed

  22. Kach J, Sandbo N, La J, Denner D, Reed EB, Akimova O, Koltsova S, Orlov SN, Dulin NO. Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A. J Biol Chem. 2014 Mar 14; 289(11):7505-13. View in: PubMed

  23. Williams JW, Yau D, Sethakorn N, Kach J, Reed EB, Moore TV, Cannon J, Jin X, Xing H, Muslin AJ, Sperling AI, Dulin NO. RGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15; 305(10):L693-701. View in: PubMed

  24. Kach J, Sandbo N, Sethakorn N, Williams J, Reed EB, La J, Tian X, Brain SD, Rajendran K, Krishnan R, Sperling AI, Birukov K, Dulin NO. Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 01; 304(11):L757-64. View in: PubMed

  25. Sandbo N, Ngam C, Torr E, Kregel S, Kach J, Dulin N. Control of myofibroblast differentiation by microtubule dynamics through a regulated localization of mDia2. J Biol Chem. 2013 May 31; 288(22):15466-73. View in: PubMed

  26. Sethakorn N, Dulin NO. RGS expression in cancer: oncomining the cancer microarray data. J Recept Signal Transduct Res. 2013 Jun; 33(3):166-71. View in: PubMed

  27. Kach J, Sethakorn N, Dulin NO. A finer tuning of G-protein signaling through regulated control of RGS proteins. Am J Physiol Heart Circ Physiol. 2012 Jul; 303(1):H19-35. View in: PubMed

  28. Sandbo N, Dulin N. Actin cytoskeleton in myofibroblast differentiation: ultrastructure defining form and driving function. Transl Res. 2011 Oct; 158(4):181-96. View in: PubMed

  29. Chakir K, Depry C, Dimaano VL, Zhu WZ, Vanderheyden M, Bartunek J, Abraham TP, Tomaselli GF, Liu SB, Xiang YK, Zhang M, Takimoto E, Dulin N, Xiao RP, Zhang J, Kass DA. Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci Transl Med. 2011 Sep 14; 3(100):100ra88. View in: PubMed

  30. Sandbo N, Lau A, Kach J, Ngam C, Yau D, Dulin NO. Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-ß. Am J Physiol Lung Cell Mol Physiol. 2011 Nov; 301(5):L656-66. View in: PubMed

  31. O'Sullivan JA, Zloza A, Kohlhapp FJ, Moore TV, Lacek AT, Dulin NO, Guevara-Patiño JA. Priming with very low-affinity peptide ligands gives rise to CD8(+) T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)ß-mediated suppression. Cancer Immunol Immunother. 2011 Nov; 60(11):1543-51. View in: PubMed

  32. Ma L, Brown M, Kogut P, Serban K, Li X, McConville J, Chen B, Bentley JK, Hershenson MB, Dulin N, Solway J, Camoretti-Mercado B. Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2011 May; 300(5):L701-9. View in: PubMed

  33. Cannon JL, Mody PD, Blaine KM, Chen EJ, Nelson AD, Sayles LJ, Moore TV, Clay BS, Dulin NO, Shilling RA, Burkhardt JK, Sperling AI. CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation. Mol Biol Cell. 2011 Apr; 22(7):954-63. View in: PubMed

  34. McConville JF, Fernandes DJ, Churchill J, Dewundara S, Kogut P, Shah S, Fuchs G, Kedainis D, Bellam SK, Patel NM, McCauley J, Dulin NO, Gupta MP, Adam S, Yoneda Y, Camoretti-Mercado B, Solway J. Nuclear import of serum response factor in airway smooth muscle. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):453-8. View in: PubMed

  35. Sethakorn N, Yau DM, Dulin NO. Non-canonical functions of RGS proteins. Cell Signal. 2010 Sep; 22(9):1274-81. View in: PubMed

  36. Kwon IK, Wang R, Thangaraju M, Shuang H, Liu K, Dashwood R, Dulin N, Ganapathy V, Browning DD. PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4. Oncogene. 2010 Jun 10; 29(23):3423-34. View in: PubMed

  37. Dowell ML, Lavoie TL, Lakser OJ, Dulin NO, Fredberg JJ, Gerthoffer WT, Seow CY, Mitchell RW, Solway J. MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle. Eur Respir J. 2010 Sep; 36(3):630-7. View in: PubMed

  38. Sun Q, Taurin S, Sethakorn N, Long X, Imamura M, Wang DZ, Zimmer WE, Dulin NO, Miano JM. Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein. J Biol Chem. 2009 Nov 20; 284(47):32582-90. View in: PubMed

  39. Taurin S, Sandbo N, Yau DM, Sethakorn N, Kach J, Dulin NO. Phosphorylation of myocardin by extracellular signal-regulated kinase. J Biol Chem. 2009 Dec 04; 284(49):33789-94. View in: PubMed

  40. Sandbo N, Kregel S, Taurin S, Bhorade S, Dulin NO. Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta. Am J Respir Cell Mol Biol. 2009 Sep; 41(3):332-8. View in: PubMed

  41. Lakser OJ, Dowell ML, Hoyte FL, Chen B, Lavoie TL, Ferreira C, Pinto LH, Dulin NO, Kogut P, Churchill J, Mitchell RW, Solway J. Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma. Eur Respir J. 2008 Nov; 32(5):1224-30. View in: PubMed

  42. Akimova OA, Taurin S, Dulin NO, Orlov SN. Purinergic inhibition of Na?,K?,Cl? cotransport in C11-MDCK cells: Role of stress-activated protein kinases. Purinergic Signal. 2008 Jun; 4(2):183-91. View in: PubMed

  43. Taurin S, Sandbo N, Yau DM, Sethakorn N, Dulin NO. Phosphorylation of beta-catenin by PKA promotes ATP-induced proliferation of vascular smooth muscle cells. Am J Physiol Cell Physiol. 2008 May; 294(5):C1169-74. View in: PubMed

  44. Yau DM, Sethakorn N, Taurin S, Kregel S, Sandbo N, Camoretti-Mercado B, Sperling AI, Dulin NO. Regulation of Smad-mediated gene transcription by RGS3. Mol Pharmacol. 2008 May; 73(5):1356-61. View in: PubMed

  45. Kwon IK, Schoenlein PV, Delk J, Liu K, Thangaraju M, Dulin NO, Ganapathy V, Berger FG, Browning DD. Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis. Cancer. 2008 Apr 01; 112(7):1462-70. View in: PubMed

  46. Haloui M, Taurin S, Akimova OA, Guo DF, Tremblay J, Dulin NO, Hamet P, Orlov SN. [Na]i -induced c-Fos expression is not mediated by activation of the 5' -promoter containing known transcriptional elements. FEBS J. 2007 Jul; 274(14):3557-3567. View in: PubMed

  47. Taurin S, Hogarth K, Sandbo N, Yau DM, Dulin NO. Gbetagamma-mediated prostacyclin production and cAMP-dependent protein kinase activation by endothelin-1 promotes vascular smooth muscle cell hypertrophy through inhibition of glycogen synthase kinase-3. J Biol Chem. 2007 Jul 06; 282(27):19518-25. View in: PubMed

  48. Sandbo N, Taurin S, Yau DM, Kregel S, Mitchell R, Dulin NO. Downregulation of smooth muscle alpha-actin expression by bacterial lipopolysaccharide. Cardiovasc Res. 2007 May 01; 74(2):262-9. View in: PubMed

  49. Taurin S, Sandbo N, Qin Y, Browning D, Dulin NO. Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase. J Biol Chem. 2006 Apr 14; 281(15):9971-6. View in: PubMed

  50. Camoretti-Mercado B, Dulin NO, Solway J. SRF function in vascular smooth muscle: when less is more? Circ Res. 2005 Sep 02; 97(5):409-10. View in: PubMed

  51. Akimova AO, Bourcier N, Taurin S, Bundey RA, Grygorczyk K, Gekle M, Insel PA, Dulin NO, Orlov SN. Cl- secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P 2Y1 receptors, phospholipase A2 and protein kinase A. J Physiol. 2005 Nov 01; 568(Pt 3):789-801. View in: PubMed

  52. Sandbo N, Qin Y, Taurin S, Hogarth DK, Kreutz B, Dulin NO. Regulation of serum response factor-dependent gene expression by proteasome inhibitors. Mol Pharmacol. 2005 Mar; 67(3):789-97. View in: PubMed

  53. Anfinogenova YJ, Baskakov MB, Kovalev IV, Kilin AA, Dulin NO, Orlov SN. Cell-volume-dependent vascular smooth muscle contraction: role of Na+, K+, 2Cl- cotransport, intracellular Cl- and L-type Ca2+ channels. Pflugers Arch. 2004 Oct; 449(1):42-55. View in: PubMed

  54. Hogarth DK, Sandbo N, Taurin S, Kolenko V, Miano JM, Dulin NO. Dual role of PKA in phenotypic modulation of vascular smooth muscle cells by extracellular ATP. Am J Physiol Cell Physiol. 2004 Aug; 287(2):C449-56. View in: PubMed

  55. Yamaguchi K, Uzzo R, Dulin N, Finke JH, Kolenko V. Renal carcinoma cells undergo apoptosis without oligonucleosomal DNA fragmentation. Biochem Biophys Res Commun. 2004 Jun 04; 318(3):710-3. View in: PubMed

  56. Camoretti-Mercado B, Dulin NO, Solway J. Serum response factor function and dysfunction in smooth muscle. Respir Physiol Neurobiol. 2003 Sep 16; 137(2-3):223-35. View in: PubMed

  57. Chandrasekar B, Mummidi S, Perla RP, Bysani S, Dulin NO, Liu F, Melby PC. Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway. Biochem J. 2003 Jul 15; 373(Pt 2):547-58. View in: PubMed

  58. Davis A, Hogarth K, Fernandes D, Solway J, Niu J, Kolenko V, Browning D, Miano JM, Orlov SN, Dulin NO. Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA. Cell Signal. 2003 Jun; 15(6):597-604. View in: PubMed

  59. Dulin NO, Fernandes DJ, Dowell M, Bellam S, McConville J, Lakser O, Mitchell R, Camoretti-Mercado B, Kogut P, Solway J. What evidence implicates airway smooth muscle in the cause of BHR? Clin Rev Allergy Immunol. 2003 Feb; 24(1):73-84. View in: PubMed

  60. Solway J, Bellam S, Dowell M, Camoretti-Mercado B, Dulin N, Fernandes D, Halayko A, Kocieniewski P, Kogut P, Lakser O, Liu HW, McCauley J, McConville J, Mitchell R. Actin dynamics: a potential integrator of smooth muscle (Dys-)function and contractile apparatus gene expression in asthma. Parker B. Francis lecture. Chest. 2003 Mar; 123(3 Suppl):392S-8S. View in: PubMed

  61. Hou Y, Lascola J, Dulin NO, Ye RD, Browning DD. Activation of cGMP-dependent protein kinase by protein kinase C. J Biol Chem. 2003 May 09; 278(19):16706-12. View in: PubMed

  62. Chandrasekar B, Melby PC, Sarau HM, Raveendran M, Perla RP, Marelli-Berg FM, Dulin NO, Singh IS. Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway. J Biol Chem. 2003 Feb 14; 278(7):4675-86. View in: PubMed

  63. Uzzo RG, Leavis P, Hatch W, Gabai VL, Dulin N, Zvartau N, Kolenko VM. Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents. Clin Cancer Res. 2002 Nov; 8(11):3579-83. View in: PubMed

  64. Taurin S, Dulin NO, Pchejetski D, Grygorczyk R, Tremblay J, Hamet P, Orlov SN. c-Fos expression in ouabain-treated vascular smooth muscle cells from rat aorta: evidence for an intracellular-sodium-mediated, calcium-independent mechanism. J Physiol. 2002 Sep 15; 543(Pt 3):835-47. View in: PubMed

  65. Niu J, Scheschonka A, Druey KM, Davis A, Reed E, Kolenko V, Bodnar R, Voyno-Yasenetskaya T, Du X, Kehrl J, Dulin NO. RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain. Biochem J. 2002 Aug 01; 365(Pt 3):677-84. View in: PubMed

  66. Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA. Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation. Curr Biol. 2001 Oct 30; 11(21):1686-90. View in: PubMed

  67. Kolenko VM, Uzzo RG, Dulin N, Hauzman E, Bukowski R, Finke JH. Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes. Apoptosis. 2001 Dec; 6(6):419-29. View in: PubMed

  68. Uzzo RG, Dulin N, Bloom T, Bukowski R, Finke JH, Kolenko V. Inhibition of NFkappaB induces caspase-independent cell death in human T lymphocytes. Biochem Biophys Res Commun. 2001 Oct 05; 287(4):895-9. View in: PubMed

  69. Dulin NO, Orlov SN, Kitchen CM, Voyno-Yasenetskaya TA, Miano JM. G-protein-coupled-receptor activation of the smooth muscle calponin gene. Biochem J. 2001 Jul 15; 357(Pt 2):587-92. View in: PubMed

  70. Thorin-Trescases N, Orlov SN, Taurin S, Dulin NO, Allen BG, deBlois D, Tremblay J, Pshezhetsky AV, Hamet P. Antiproliferative effect of brief exposure to cholera toxin in vascular smooth muscle cells: role of cAMP and protein kinase A. Can J Physiol Pharmacol. 2001 Jun; 79(6):471-80. View in: PubMed

  71. Dulin NO, Niu J, Browning DD, Ye RD, Voyno-Yasenetskaya T. Cyclic AMP-independent activation of protein kinase A by vasoactive peptides. J Biol Chem. 2001 Jun 15; 276(24):20827-30. View in: PubMed

  72. Chen ZJ, Miao ZH, Vetter M, Dulin N, Liu S, Che D, Hughes B, Murad F, Douglas J, Chang CH. Molecular cloning of a regulatory protein for membrane-bound guanylate cyclase GC-A. Biochem Biophys Res Commun. 2000 Nov 11; 278(1):106-11. View in: PubMed

  73. Orlov SN, Taurin S, Thorin-Trescases N, Dulin NO, Tremblay J, Hamet P. Inversion of the intracellular Na(+)/K(+) ratio blocks apoptosis in vascular smooth muscle cells by induction of RNA synthesis. Hypertension. 2000 May; 35(5):1062-8. View in: PubMed

  74. Dulin NO, Pratt P, Tiruppathi C, Niu J, Voyno-Yasenetskaya T, Dunn MJ. Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis. J Biol Chem. 2000 Jul 14; 275(28):21317-23. View in: PubMed

  75. Orlov SN, Dulin NO, Gagnon F, Gekle M, Douglas JG, Schwartz JH, Hamet P. Purinergic modulation of Na(+),K(+),Cl(-) cotransport and MAP kinases is limited to C11-MDCK cells resembling intercalated cells from collecting ducts. J Membr Biol. 1999 Dec 01; 172(3):225-34. View in: PubMed

  76. Orlov SN, Thorin-Trescases N, Dulin NO, Dam TV, Fortuno MA, Tremblay J, Hamet P. Activation of cAMP signaling transiently inhibits apoptosis in vascular smooth muscle cells in a site upstream of caspase-3. Cell Death Differ. 1999 Jul; 6(7):661-72. View in: PubMed

  77. Thibonnier M, Berti-Mattera LN, Dulin N, Conarty DM, Mattera R. Signal transduction pathways of the human V1-vascular, V2-renal, V3-pituitary vasopressin and oxytocin receptors. Prog Brain Res. 1998; 119:147-61. View in: PubMed

  78. Gagnon F, Dulin NO, Tremblay J, Hamet P, Orlov SN. ATP-induced inhibition of Na+, K+, Cl- cotransport in Madin-Darby canine kidney cells: lack of involvement of known purinoceptor-coupled signaling pathways. J Membr Biol. 1999 Jan 15; 167(2):193-204. View in: PubMed

  79. Dulin NO, Sorokin A, Reed E, Elliott S, Kehrl JH, Dunn MJ. RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11. Mol Cell Biol. 1999 Jan; 19(1):714-23. View in: PubMed

  80. Dulin NO, Sorokin A, Douglas JG. Arachidonate-induced tyrosine phosphorylation of epidermal growth factor receptor and Shc-Grb2-Sos association. Hypertension. 1998 Dec; 32(6):1089-93. View in: PubMed

  81. Dulin NO, Alexander LD, Harwalkar S, Falck JR, Douglas JG. Phospholipase A2-mediated activation of mitogen-activated protein kinase by angiotensin II. Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):8098-102. View in: PubMed

  82. Sorokin A, Reed E, Nnkemere N, Dulin NO, Schlessinger J. Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways. Oncogene. 1998 May 14; 16(19):2425-34. View in: PubMed

  83. Harwalkar S, Chang CH, Dulin NO, Douglas JG. Role of phospholipase A2 isozymes in agonist-mediated signaling in proximal tubular epithelium. Hypertension. 1998 Mar; 31(3):809-14. View in: PubMed

  84. Thibonnier M, Preston JA, Dulin N, Wilkins PL, Berti-Mattera LN, Mattera R. The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways. Endocrinology. 1997 Oct; 138(10):4109-22. View in: PubMed

  85. Dulin NO, Ernsberger P, Suciu DJ, Douglas JG. Rabbit renal epithelial angiotensin II receptors. Am J Physiol. 1994 Nov; 267(5 Pt 2):F776-82. View in: PubMed

  86. Dulin N, Madhun ZT, Chang CH, Berti-Mattera L, Dickens D, Douglas JG. Angiotensin IV receptors and signaling in opossum kidney cells. Am J Physiol. 1995 Nov; 269(5 Pt 2):F644-52. View in: PubMed

  87. Postnov IuV, Kravtsov GM, Kotelevtsev IuV, Dulin NO, Postnov IIu. [Changes in erythrocyte volume in relation to characteristics of protein phosphorylation of the membrane cytoskeleton in hypertension: role of protein kinase C]. Kardiologiia. 1987 Aug; 27(8):60-5. View in: PubMed

  88. Kravtsov GM, Dulin NO, Postnov IuV. [Protein kinase A and C activity of erythrocytes in patients with essential hypertension]. Kardiologiia. 1988 May; 28(5):96-8. View in: PubMed

  89. Kravtsov GM, Dulin NO, Postnov YV. Activity of protein kinase C in erythrocytes in primary hypertension. J Hypertens. 1988 Nov; 6(11):853-7. View in: PubMed

  90. Kravtsov GM, Dulin NO, Kotelevtsev IuV, Postnov IuV. [Regulation of the shape and size of human erythrocytes by protein kinases A and C]. Biokhimiia. 1988 Aug; 53(8):1296-303. View in: PubMed

  91. Kravtsov GM, Dulin NO, Postnov IuV. [Protein kinase C activity in the brain tissue of spontaneously hypertensive rats]. Biull Eksp Biol Med. 1989 Jul; 108(7):42-4. View in: PubMed

  92. Dulin NO, Goncharenko EN, Kudriashov IuB, Graevskaia EE, Kravtsov GM. [The role of protein phosphorylation in mast cell secretion, stimulated by concanavalin A. Connection to the cytoskeleton]. Biokhimiia. 1989 Sep; 54(9):1428-33. View in: PubMed

  93. Dulin NO, Kravtsov GM, Graevskaia EE, Kudriashov IuB. [Protein phosphorylation during mast cell secretion in radioprophylaxis]. Radiobiologiia. 1990 Jan-Feb; 30(1):32-5. View in: PubMed

  94. Kravtsov GM, Dulin NO. Protein kinase C activity in erythrocytes in primary hypertension: regulation of cell shape and cation transport. Physiol Bohemoslov. 1990; 39(1):27-36. View in: PubMed

  95. Kravtsov GM, Dulin NO, Postnov YV. A mechanism of calcium binding by the erythrocyte skeleton: some features in primary hypertension. J Hypertens Suppl. 1991 Dec; 9(6):S300-1. View in: PubMed

  96. Kravtsov GM, Dulin NO, Postnov IuV. [Calcium binding to the erythrocyte cytoskeleton in spontaneously hypertensive rats]. Kardiologiia. 1991 Oct; 31(10):77-81. View in: PubMed