Megan Mcnerney, MD PhD

The McNerney lab studies the genomic changes in blood cancers with the goal of identifying therapeutic vulnerabilities. We focus on myeloid malignancies which are particularly difficult to treat. We apply a variety of functional genomics approaches and model systems to decipher changes in the cancer genome. Ongoing and available projects include studies of hematopoietic stem cell regulation, gene regulation during hematopoiesis, contiguous gene syndromes in cancer, and oncogenic signaling. Please visit our webpage for more information https://voices.uchicago.edu/mcnerneylab/

The University of Chicago
Chicago
Postdoctoral - Genomics and Systems Biology
2014

The University of Chicago
Chicago
Residency - Clinical Pathology
2010

The University of Chicago
Chicago
MD - Medicine
2007

The University of Chicago
Chicago
PhD - Immunology
2005

Northwestern University
Evanston
B.A. - Molecular and Cellular Biology
1999

Haploinsufficient Transcription Factors in Myeloid Neoplasms.
Haploinsufficient Transcription Factors in Myeloid Neoplasms. Annu Rev Pathol. 2024 Jan 24; 19:571-598.
PMID: 37906947

Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells.
Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells. Oncogene. 2023 03; 42(12):881-893.
PMID: 36725889

Inherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms.
Inherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms. Br J Haematol. 2023 02; 200(4):489-493.
PMID: 36349721

EGR1 Haploinsufficiency Confers a Fitness Advantage to Hematopoietic Stem Cells Following Chemotherapy.
EGR1 Haploinsufficiency Confers a Fitness Advantage to Hematopoietic Stem Cells Following Chemotherapy. Exp Hematol. 2022 11; 115:54-67.
PMID: 35995095

The significance of CUX1 and chromosome 7 in myeloid malignancies.
The significance of CUX1 and chromosome 7 in myeloid malignancies. Curr Opin Hematol. 2022 03 01; 29(2):92-102.
PMID: 35084368

CRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions.
CRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions. Leukemia. 2022 05; 36(5):1421-1425.
PMID: 35034954

Genomic studies controvert the existence of the CUX1 p75 isoform.
Genomic studies controvert the existence of the CUX1 p75 isoform. Sci Rep. 2022 01 07; 12(1):151.
PMID: 34997000

Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells.
Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells. Cell Death Dis. 2021 10 27; 12(11):1005.
PMID: 34707089

Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms.
Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms. Blood. 2021 09 02; 138(9):790-805.
PMID: 34473231

Loss of a 7q gene, CUX1, disrupts epigenetic-driven DNA repair and drives therapy-related myeloid neoplasms.
Loss of a 7q gene, CUX1, disrupts epigenetic-driven DNA repair and drives therapy-related myeloid neoplasms. Blood. 2021 May 26.
PMID: 34041524

View All Publications

Leukemia and Lymphoma Society Scholar Award
2022

Faculty Award for Excellence in Graduate Teaching and Mentoring
2020

American Cancer Society Research Scholar Award
2019

American Society of Hematology Junior Faculty Scholar Award
2017

Nachman Fellow, Dept. of Pediatrics Hematology-Oncology
2015

ā€œVā€ Foundation in Cancer Research Scholar Award
2014

Leukemia and Lymphoma Society, Illinois Chapter Researcher of the Year
2013

Evans Travel Award, FASEB Hematologic Malignancies Science Research Conference
2013

Cancer Research Foundation Young Investigator Award
2013

Leukemia and Lymphoma Society Fellow Award
2011

Robert W. Wissler Fellowship Award, Department of Pathology
2010

Resident Research Grant, College of American Pathologists
2009

Leon Jacobson Prize for Senior Scientific Presentation, Pritzker School of Medicine
2007

Honorable Mention Best PhD Dissertation Award, Biological Sciences, University of Chicago
2006

Committee on Immunology Best PhD Thesis Award, University of Chicago
2006

Robert E. Priest Pathology Merit Award, Department of Pathology, University of Chicago
2005

Doolittle-Harrison Travel Fellowship, University of Chicago
2004

Elaine Frank Family Fellowship for Medical Research, MSTP, University of Chicago
2003

Medical Scientist Training Program, NIH
2000 - 2007

Graduation with Departmental Honors, Biological Sciences, Northwestern University
1999

Graduation Cum Laude, Northwestern University
1999

Edgar Macey Scholarship for Summer Research, Northwestern University
1997