1. Home
  2. People
  3. Faculty
  4. Marsha Rosner

Marsha Rosner

Professor
mrosner@uchicago.edu
Research Summary
Cancer is the second leading cause of death but, unlike heart disease, it has been a difficult disease to effectively understand or treat. The reason relates to the complexity and heterogeneity of the disease. Most tumors have complicated origins and are driven by rare mutations. Furthermore, different tissues have distinct cancers, individual tissues have multiple cancer subtypes, and tumors are composed of cells that are both genetically and phenotypically diverse. Thus, every tumor is unique and dynamic. The cause of lethality in most solid tumors such as breast cancer is the metastatic dissemination of tumor cells throughout the body. Metastasis is characterized by many distinct properties that are driven by changing stresses in the tumor microenvironment. Underlying all of these events are subcellular signaling pathways within tumor and environmental cells that are ultimately responsible for driving cells to a tumorigenic state. The current focus of my laboratory is to understand fundamental signaling mechanisms leading to the generation of tumor cells and their progression to metastatic disease, particularly in triple-negative breast cancer that lacks targeted therapies. We use systems level approaches including activity-based proteomics, RNAseq, ChIPseq, and mass spectrometry as well as computational, molecular, biophysical, cellular and mouse model-based methodologies to identify and characterize key regulators of tumor growth and metastasis. As an additional tool, we have utilized a specific physiological suppressor of metastasis, Raf Kinase Inhibitory Protein (RKIP or PEBP1), and a downstream target of RKIP in cells, BACH1, to identify both molecular and cellular mediators of metastasis. Our recent studies have shown that regulators of metastasis control multiple processes within the tumor cell microenvironment including metabolism, redox state, extracellular matrix, and recruitment and programming of tumor-associated macrophages. These factors also direct extracellular vesicles (exosomes) secreted by tumor cells to reprogram other cells in the body toward a pro-metastatic phenotype. Correlating omic-generated data from these studies with clinical data from cancer patients led to the identification of novel signaling modules that we used to build gene signatures that predict the metastatic potential of a tumor. More recently, our studies have led us to potential therapeutic treatments based on the concept of targeting key regulators of tumorigenesis, mimicking the action of metastasis suppressors such as RKIP or reprogramming signaling networks in cells to sensitize tumors to therapeutic agents.
Keywords
Cancer, Breast, Signal Transduction Pathways, Metastasis, Exosomes, Macrophages, Phosphorylation, Oxidative Stress, Single Cell Analysis
Education
  • Harvard University, Cambridge, MA, AB Biochemistry 06/1972
  • Massachusetts Institute of Technology, Cambridge, MA, Ph.D. Biochemistry 06/1978
  • Massachusetts Institute of Technology, Cambridge, MA, Postdoctoral Fellow Biochemistry/MolBio 09/1981
  • Massachusetts Institute of Technology , Cambridge, MA, Instructor Biochemistry/MolBio 09/1982
Biosciences Graduate Program Association
Awards & Honors
  • 1972 - 1972 MIT Endowed Fellowship MIT
  • 1973 - 1975 Sloan Research Traineeship (Biophysics) MIT
  • 1975 - 1977 Inst. National Research Service Award MIT
  • 1978 - 1980 American Cancer Society Postdoctoral Fellowship MIT
  • 1986 - 1986 International Life Sciences Institute Research Foundation Award MIT
  • 1991 - 1991 Quantrell Award for Excellence in Undergraduate Teaching, (Cell Biology) University of Chicago
  • 1999 - pres Fellow, Institute of Medicine of Chicago University of Chicago
  • 2001 - 2001 Quantrell Award for Excellence in Undergraduate Teaching (Cancer Biology) University of Chicago
  • 2011 - 2011 Gerald N Wogan Prize Lecture, Massachusetts Institute of Technology University of Chicago
  • 2014 - 2014 Fellow, American Association for the Advancement of Science (AAAS) University of Chicago
Publications

  1. SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells. mBio. 2022 10 26; 13(5):e0241522. View in: PubMed

  2. SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1a/XBP1 ER stress pathway in human lung-derived cells. bioRxiv. 2022 Jun 13. View in: PubMed

  3. Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop. Proc Natl Acad Sci U S A. 2022 06 21; 119(25):e2121867119. View in: PubMed

  4. Harnessing RKIP to Combat Heart Disease and Cancer. Cancers (Basel). 2022 Feb 09; 14(4). View in: PubMed

  5. Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses. Sci Adv. 2022 Feb 25; 8(8):eabi6110. View in: PubMed

  6. New strategies for targeting kinase networks in cancer. J Biol Chem. 2021 10; 297(4):101128. View in: PubMed

  7. Tumor Extracellular Vesicles Regulate Macrophage-Driven Metastasis through CCL5. Cancers (Basel). 2021 Jul 10; 13(14). View in: PubMed

  8. Limited inhibition of multiple nodes in a driver network blocks metastasis. Elife. 2021 05 11; 10. View in: PubMed

  9. Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response. bioRxiv. 2021 Mar 10. View in: PubMed

  10. Observation and Control of Gene Expression Noise: Barrier Crossing Analogies Between Drug Resistance and Metastasis. Front Genet. 2020; 11:586726. View in: PubMed

  11. Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer. J Exp Med. 2019 06 03; 216(6):1345-1358. View in: PubMed

  12. Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. Nature. 2019 04; 568(7751):254-258. View in: PubMed

  13. Targeting Raf Kinase Inhibitory Protein Regulation and Function. Cancers (Basel). 2018 Sep 04; 10(9). View in: PubMed

  14. Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):13453-13458. View in: PubMed

  15. Raf kinase inhibitor protein: lessons of a better way for ?-adrenergic receptor activation in the heart. J Physiol. 2017 06 15; 595(12):4073-4087. View in: PubMed

  16. Insulin-Degrading Enzyme Does Not Require Peroxisomal Localization for Insulin Degradation. Endocrinology. 1997 Aug 01; 138(8):3444-3451. View in: PubMed

  17. Gene expression in local stroma reflects breast tumor states and predicts patient outcome. Sci Rep. 2016 12 16; 6:39240. View in: PubMed

  18. Interaction of tRNA with MEK2 in pancreatic cancer cells. Sci Rep. 2016 06 15; 6:28260. View in: PubMed

  19. Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages. Cancer Res. 2015 Oct 01; 75(19):4063-73. View in: PubMed

  20. Noise-Driven Phenotypic Heterogeneity with Finite Correlation Time in Clonal Populations. PLoS One. 2015; 10(7):e0132397. View in: PubMed

  21. RKIP structure drives its function: a three-state model for regulation of RKIP. Crit Rev Oncog. 2014; 19(6):483-8. View in: PubMed

  22. Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer. Crit Rev Oncog. 2014; 19(6):447-54. View in: PubMed

  23. Conceptualizing cancer drugs as classifiers. PLoS One. 2014; 9(9):e106444. View in: PubMed

  24. Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):E364-73. View in: PubMed

  25. A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients. PLoS One. 2013; 8(12):e82125. View in: PubMed

  26. RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2. Oncogene. 2014 Jul 03; 33(27):3528-37. View in: PubMed

  27. HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9920-5. View in: PubMed

  28. RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy. PLoS One. 2013; 8(3):e59104. View in: PubMed

  29. Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells. RNA. 2013 Apr; 19(4):461-6. View in: PubMed

  30. RKIP regulates MAP kinase signaling in cells with defective B-Raf activity. Cell Signal. 2013 May; 25(5):1156-65. View in: PubMed

  31. A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer. PLoS One. 2012; 7(11):e49893. View in: PubMed

  32. Anti-tumor effects of an engineered "killer" transfer RNA. Biochem Biophys Res Commun. 2012 Oct 12; 427(1):148-53. View in: PubMed

  33. Identification of novel metastasis suppressor signaling pathways for breast cancer. Cell Cycle. 2012 Jul 01; 11(13):2452-7. View in: PubMed

  34. Nonheritable cellular variability accelerates the evolutionary processes of cancer. PLoS Biol. 2012; 10(4):e1001296. View in: PubMed

  35. RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes. Int J Breast Cancer. 2012; 2012:124704. View in: PubMed

  36. Har Gobind Khorana 1922-2011. Cell. 2011 Dec 23; 147(7):1433-5. View in: PubMed

  37. Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas. PLoS One. 2012; 7(1):e30769. View in: PubMed

  38. An integrated view of cyclin E function and regulation. Cell Cycle. 2012 Jan 01; 11(1):57-64. View in: PubMed

  39. Proliferation potential of human amniotic fluid stem cells differently responds to mercury and lead exposure. Amino Acids. 2012 Aug; 43(2):937-49. View in: PubMed

  40. Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer. EMBO J. 2011 Aug 26; 30(21):4500-14. View in: PubMed

  41. p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6. Amino Acids. 2012 Jun; 42(6):2251-6. View in: PubMed

  42. Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR. Oncogene. 2011 Nov 03; 30(44):4509-22. View in: PubMed

  43. Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin. Head Neck. 2011 Dec; 33(12):1774-82. View in: PubMed

  44. Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context. Mol Cancer Ther. 2010 Oct; 9(10):2814-24. View in: PubMed

  45. MAP kinase regulation of the mitotic spindle checkpoint. Methods Mol Biol. 2010; 661:497-505. View in: PubMed

  46. Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236. Amino Acids. 2011 Feb; 40(2):595-600. View in: PubMed

  47. Evidence for cell cycle-dependent, rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244. Amino Acids. 2010 Nov; 39(5):1487-92. View in: PubMed

  48. Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands. PLoS One. 2010 May 05; 5(5):e10479. View in: PubMed

  49. Innate immune and chemically triggered oxidative stress modifies translational fidelity. Nature. 2009 Nov 26; 462(7272):522-6. View in: PubMed

  50. Embryoid body formation of human amniotic fluid stem cells depends on mTOR. Oncogene. 2010 Feb 18; 29(7):966-77. View in: PubMed

  51. tRNA over-expression in breast cancer and functional consequences. Nucleic Acids Res. 2009 Nov; 37(21):7268-80. View in: PubMed

  52. CDKs as therapeutic targets for the human genetic disease tuberous sclerosis? Eur J Clin Invest. 2009 Dec; 39(12):1033-5. View in: PubMed

  53. A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. Blood. 2009 Nov 12; 114(20):4592-600. View in: PubMed

  54. MicroRNA-regulated feed forward loop network. Cell Cycle. 2009 Aug 15; 8(16):2477-8. View in: PubMed

  55. Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme. FASEB J. 2009 Nov; 23(11):3734-42. View in: PubMed

  56. Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. PLoS One. 2009 Jun 24; 4(6):e6028. View in: PubMed

  57. Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J. 2009 Feb 18; 28(4):347-58. View in: PubMed

  58. mTOR phosphorylated at S2448 binds to raptor and rictor. Amino Acids. 2010 Jan; 38(1):223-8. View in: PubMed

  59. A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. Cancer Res. 2009 Jan 01; 69(1):65-74. View in: PubMed

  60. Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism. Mol Cell Biol. 2009 Mar; 29(5):1306-20. View in: PubMed

  61. Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues. Int J Mol Med. 2008 Oct; 22(4):421-31. View in: PubMed

  62. Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines. Biol Chem. 2008 Nov; 389(11):1441-5. View in: PubMed

  63. Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target. Expert Opin Ther Targets. 2008 Oct; 12(10):1275-87. View in: PubMed

  64. Tuberin, p27 and mTOR in different cells. Amino Acids. 2009 Feb; 36(2):297-302. View in: PubMed

  65. Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor. Cell Res. 2008 Apr; 18(4):452-7. View in: PubMed

  66. Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations. Endocr Relat Cancer. 2007 Dec; 14(4):1053-62. View in: PubMed

  67. Ras mediates cell survival by regulating tuberin. Oncogene. 2008 Mar 27; 27(14):2072-83. View in: PubMed

  68. Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1. J Biol Chem. 2007 Jul 06; 282(27):19781-7. View in: PubMed

  69. Cytoplasmic/nuclear localization of tuberin in different cell lines. Amino Acids. 2007 Nov; 33(4):575-9. View in: PubMed

  70. Nuclear/cytoplasmic localization of Akt activity in the cell cycle. Amino Acids. 2007; 32(3):341-5. View in: PubMed

  71. MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation. Cell Div. 2007 Jan 10; 2:1. View in: PubMed

  72. Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels. Int J Oncol. 2007 Jan; 30(1):73-80. View in: PubMed

  73. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature. 2006 Oct 19; 443(7113):870-4. View in: PubMed

  74. Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Mol Cell. 2006 Aug; 23(4):561-74. View in: PubMed

  75. Akt regulates nuclear/cytoplasmic localization of tuberin. Oncogene. 2007 Jan 25; 26(4):521-31. View in: PubMed

  76. Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cancer Res. 2006 Jun 15; 66(12):6296-303. View in: PubMed

  77. Tuberin negatively affects BCL-2's cell survival function. Amino Acids. 2006 Jun; 30(4):391-6. View in: PubMed

  78. Tuberin activates the proapoptotic molecule BAD. Oncogene. 2006 Oct 19; 25(49):6467-79. View in: PubMed

  79. The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition. Biochem Biophys Res Commun. 2006 May 19; 343(4):1032-7. View in: PubMed

  80. NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell. 2006 Feb 17; 21(4):467-80. View in: PubMed

  81. NMR assignment of rat Raf kinase inhibitor protein. J Biomol NMR. 2006; 36 Suppl 1:4. View in: PubMed

  82. CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders. Hum Mol Genet. 2005 Dec 15; 14(24):3775-86. View in: PubMed

  83. 14-3-3 proteins are involved in the regulation of mammalian cell proliferation. Amino Acids. 2006 Feb; 30(1):105-9. View in: PubMed

  84. Anthrax edema factor potency depends on mode of cell entry. Biochem Biophys Res Commun. 2005 Sep 30; 335(3):850-7. View in: PubMed

  85. Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. J Biol Chem. 2005 Jul 01; 280(26):24931-40. View in: PubMed

  86. Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein. Cell Res. 2005 Jan; 15(1):19-23. View in: PubMed

  87. Proteins interacting with the tuberous sclerosis gene products. Amino Acids. 2004 Oct; 27(2):119-28. View in: PubMed

  88. ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway. J Biol Chem. 2004 May 28; 279(22):23073-81. View in: PubMed

  89. Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma. Am J Respir Crit Care Med. 2004 Mar 15; 169(6):703-11. View in: PubMed

  90. Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons. J Neurochem. 2003 Mar; 84(5):982-96. View in: PubMed

  91. Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J Biol Chem. 2003 Apr 11; 278(15):13061-8. View in: PubMed

  92. The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol. 2002 Dec; 22(24):8571-9. View in: PubMed

  93. Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta. Am J Respir Cell Mol Biol. 2002 Aug; 27(2):204-13. View in: PubMed

  94. Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation. J Neurochem. 2002 Jun; 81(5):922-34. View in: PubMed

  95. ERK8, a new member of the mitogen-activated protein kinase family. J Biol Chem. 2002 May 10; 277(19):16733-43. View in: PubMed

  96. Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression. Oncogene. 2001 Aug 09; 20(35):4904-9. View in: PubMed

  97. FGF induces a switch in death receptor pathways in neuronal cells. J Neurosci. 2001 Jul 15; 21(14):4996-5006. View in: PubMed

  98. Tuberous sclerosis gene products in proliferation control. Mutat Res. 2001 Jul; 488(3):233-9. View in: PubMed

  99. Cloning and characterization of MST4, a novel Ste20-like kinase. J Biol Chem. 2001 Jun 22; 276(25):22439-45. View in: PubMed

  100. ERK7 is an autoactivated member of the MAPK family. J Biol Chem. 2001 Jun 15; 276(24):21272-9. View in: PubMed

  101. A novel mitogen-activated protein kinase is responsive to Raf and mediates growth factor specificity. Mol Cell Biol. 2001 Mar; 21(6):2235-47. View in: PubMed

  102. Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization. Biochem J. 2000 Oct 15; 351 Pt 2:509-16. View in: PubMed

  103. The TSC1 gene product, hamartin, negatively regulates cell proliferation. Hum Mol Genet. 2000 Jul 22; 9(12):1721-7. View in: PubMed

  104. Different protein kinase C isoforms determine growth factor specificity in neuronal cells. Mol Cell Biol. 2000 Aug; 20(15):5392-403. View in: PubMed

  105. Functional human insulin-degrading enzyme can be expressed in bacteria. Protein Expr Purif. 2000 Jun; 19(1):91-8. View in: PubMed

  106. Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells. Cancer Res. 2000 Apr 15; 60(8):2263-72. View in: PubMed

  107. Differential effect of cycloheximide on neuronal and glioma cells treated with chemotherapy and radiation. J Neurooncol. 1999; 45(1):19-26. View in: PubMed

  108. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000 Mar 01; 20(5):1657-65. View in: PubMed

  109. A proline- and glutamine-rich protein promotes apoptosis in neuronal cells. J Neurochem. 1999 Aug; 73(2):612-22. View in: PubMed

  110. Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells. J Biol Chem. 1999 Jul 30; 274(31):22065-71. View in: PubMed

  111. Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells. Mol Cell Biol. 1999 Jun; 19(6):4209-18. View in: PubMed

  112. Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth. Mol Cell Biol. 1999 Feb; 19(2):1301-12. View in: PubMed

  113. Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel. J Biol Chem. 1999 Jan 15; 274(3):1621-7. View in: PubMed

  114. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem. 1998 Dec 04; 273(49):32730-8. View in: PubMed

  115. Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways. Mol Cell Biol. 1998 Apr; 18(4):2272-81. View in: PubMed

  116. Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Mol Cell Biol. 1998 Apr; 18(4):2143-52. View in: PubMed

  117. Role of cyclins in neuronal differentiation of immortalized hippocampal cells. Mol Cell Biol. 1997 Nov; 17(11):6585-97. View in: PubMed

  118. Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin. Cancer Res. 1997 Aug 01; 57(15):3168-73. View in: PubMed

  119. Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src. Mol Cell Biol. 1997 Aug; 17(8):4633-43. View in: PubMed

  120. Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation. Endocrinology. 1997 Aug; 138(8):3444-51. View in: PubMed

  121. Cyclin D1 is required for S phase traversal in bovine tracheal myocytes. Am J Physiol. 1997 Jun; 272(6 Pt 1):L1205-10. View in: PubMed

  122. Insulin gene expression in immortalized rat hippocampal and pheochromocytoma-12 cell lines. Regul Pept. 1997 Mar 12; 69(1):7-14. View in: PubMed

  123. Identification of the cleavage sites of transforming growth factor alpha by insulin-degrading enzymes. Biochim Biophys Acta. 1997 Apr 04; 1338(2):207-14. View in: PubMed

  124. Mutation of Di-leucine residues in the juxtamembrane region alters EGF receptor expression. Biochemistry. 1996 Nov 19; 35(46):14618-24. View in: PubMed

  125. Apoptosis induced by differentiation or serum deprivation in an immortalized central nervous system neuronal cell line. J Neurochem. 1996 Nov; 67(5):1908-20. View in: PubMed

  126. Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C. J Biol Chem. 1996 May 31; 271(22):12891-6. View in: PubMed

  127. Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells. Mol Cell Biol. 1996 Apr; 16(4):1458-70. View in: PubMed

  128. Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding. J Biol Chem. 1993 Apr 15; 268(11):7943-8. View in: PubMed

  129. Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation. J Biol Chem. 1993 Feb 25; 268(6):4488-93. View in: PubMed

  130. Role of threonine residues in regulation of the epidermal growth factor receptor by protein kinase C and mitogen-activated protein kinase. J Biol Chem. 1993 Jul 25; 268(21):15536-43. View in: PubMed

  131. Mitogen-activated protein kinase regulates the epidermal growth factor receptor through activation of a tyrosine phosphatase. J Biol Chem. 1993 Jun 25; 268(18):13050-4. View in: PubMed

  132. Corneal electrode for recording electroretinograms in rats. Doc Ophthalmol. 1993; 83(2):175-80. View in: PubMed

  133. Identification of an epidermal growth factor receptor transcriptional repressor. J Biol Chem. 1994 Feb 11; 269(6):4307-12. View in: PubMed

  134. Localization of immunoreactive epidermal growth factor receptor in neonatal and adult rat hippocampus. Brain Res. 1993 Dec 17; 631(1):65-71. View in: PubMed

  135. Adenovirus and protein kinase C have distinct molecular requirements for regulating epidermal growth factor receptor trafficking. J Cell Physiol. 1993 Dec; 157(3):535-43. View in: PubMed

  136. Patient dissatisfaction after functionally successful conjunctivodacryocystorhinostomy with Jones tube. Am J Ophthalmol. 1994 May 15; 117(5):636-42. View in: PubMed

  137. Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium. J Biol Chem. 1994 Mar 11; 269(10):7337-41. View in: PubMed

  138. Functional analysis of conserved residues in the active site of insulin-degrading enzyme. J Biol Chem. 1993 Oct 15; 268(29):21538-44. View in: PubMed

  139. Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line. J Biol Chem. 1994 Sep 09; 269(36):22599-606. View in: PubMed

  140. Induction of epidermal growth factor receptor gene transcription by transforming growth factor beta 1: association with loss of protein binding to a negative regulatory element. Cell Growth Differ. 1994 Aug; 5(8):801-9. View in: PubMed

  141. Hydrogen peroxide stimulates mitogen-activated protein kinase in bovine tracheal myocytes: implications for human airway disease. Am J Respir Cell Mol Biol. 1994 Nov; 11(5):577-85. View in: PubMed

  142. Conditional immortalization of neuronal cells from postmitotic cultures and adult CNS. Brain Res. 1994 Sep 12; 656(2):396-404. View in: PubMed

  143. Identification of zinc ligands of the insulin-degrading enzyme. J Biol Chem. 1994 Dec 30; 269(52):33140-5. View in: PubMed

  144. Activation of mitogen-activated protein kinase by epidermal growth factor in hippocampal neurons and neuronal cell lines. J Neurochem. 1993 Oct; 61(4):1376-87. View in: PubMed

  145. Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues. Endocrinology. 1993 Feb; 132(2):604-11. View in: PubMed

  146. Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells. J Biol Chem. 1995 Aug 25; 270(34):19908-13. View in: PubMed

  147. Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis. Am J Physiol. 1995 Jun; 268(6 Pt 1):L894-901. View in: PubMed

  148. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J. 1995 Oct 02; 14(19):4662-75. View in: PubMed

  149. N-asparagine-linked oligosaccharides: biosynthesis of the lipid-linked oligosaccharides. Methods Enzymol. 1982; 83:399-408. View in: PubMed

  150. Relationship of GIX antigen expression to the glycosylation of murine leukemia virus glycoprotein. Proc Natl Acad Sci U S A. 1980 Nov; 77(11):6420-4. View in: PubMed

  151. Host-dependent variation of asparagine-linked oligosaccharides at individual glycosylation sites of Sindbis virus glycoproteins. J Biol Chem. 1983 Feb 25; 258(4):2548-54. View in: PubMed

  152. Selective cleavage by endo-beta-N-acetylglucosaminidase H at individual glycosylation sites of Sindbis virion envelope glycoproteins. J Biol Chem. 1983 Feb 25; 258(4):2555-61. View in: PubMed

  153. Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. Proc Natl Acad Sci U S A. 1984 May; 81(10):3034-8. View in: PubMed

  154. Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor. J Biol Chem. 1984 Oct 25; 259(20):12502-7. View in: PubMed

  155. Characterization of murine-specific leukemia virus receptor from L cells. J Virol. 1986 Jun; 58(3):900-8. View in: PubMed

  156. Decreased levels of hepatic epidermal growth factor receptors in obese hyperglycemic rodents. J Biol Chem. 1987 Sep 05; 262(25):12356-64. View in: PubMed

  157. Growth factors modify the epidermal growth factor receptor through multiple pathways. J Cell Biochem. 1987 May; 34(1):1-11. View in: PubMed

  158. Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells. J Biol Chem. 1987 Feb 05; 262(4):1442-5. View in: PubMed

  159. Growth state-dependent regulation of protein kinase C in normal and transformed murine cells. Cancer Res. 1987 Feb 15; 47(4):1081-6. View in: PubMed

  160. Characterization of protein kinase C from normal and transformed cultured murine fibroblasts. Biochem Biophys Res Commun. 1987 Jul 15; 146(1):140-6. View in: PubMed

  161. Thapsigargin, a novel promoter, phosphorylates the epidermal growth factor receptor at threonine 669. Biochem Biophys Res Commun. 1988 Dec 15; 157(2):740-6. View in: PubMed

  162. Transforming growth factor-beta increases transcription of the genes encoding the epidermal growth factor receptor and fibronectin in normal rat kidney fibroblasts. J Biol Chem. 1988 Dec 25; 263(36):19519-24. View in: PubMed

  163. Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster. Biochemistry. 1988 Jun 14; 27(12):4237-44. View in: PubMed

  164. Developmental regulation of an insulin-degrading enzyme from Drosophila melanogaster. Proc Natl Acad Sci U S A. 1988 May; 85(10):3469-73. View in: PubMed

  165. Characterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors. J Cell Biol. 1987 Jul; 105(1):449-56. View in: PubMed

  166. Identification of a novel receptor in Drosophila for both epidermal growth factor and insulin. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8443-7. View in: PubMed

  167. Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter. Cancer Res. 1987 Sep 01; 47(17):4618-22. View in: PubMed

  168. Basic and acidic fibroblast growth factors modulate the epidermal growth factor receptor by a protein kinase C-independent pathway. Biochem Biophys Res Commun. 1989 Oct 31; 164(2):796-803. View in: PubMed

  169. Regulation of epidermal growth factor receptor gene expression by retinoic acid and epidermal growth factor. J Biol Chem. 1989 Feb 25; 264(6):3230-4. View in: PubMed

  170. Substance abuse in pregnant women: recent experience at the Perinatal Center for Chemical Dependence of Northwestern Memorial Hospital. Obstet Gynecol. 1989 May; 73(5 Pt 1):715-20. View in: PubMed

  171. Temporal parameters of low energy laser irradiation for optimal delay of post-traumatic degeneration of rat optic nerve. Brain Res. 1989 Jan 09; 476(2):205-12. View in: PubMed

  172. An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin. J Cell Biol. 1989 Sep; 109(3):1301-7. View in: PubMed

  173. Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites. Biochemistry. 1989 Mar 21; 28(6):2471-7. View in: PubMed

  174. Structure-activity studies of the nonphorbol tumor promoter palytoxin in Swiss 3T3 cells. Cancer Res. 1989 Nov 01; 49(21):5837-42. View in: PubMed

  175. Sodium as a mediator of non-phorbol tumor promoter action. Down-modulation of the epidermal growth factor receptor by palytoxin. J Biol Chem. 1989 Sep 05; 264(25):14668-73. View in: PubMed

  176. Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway. J Biol Chem. 1989 Jan 05; 264(1):213-9. View in: PubMed

  177. Basic fibroblast-like growth factor is present in the conditioned medium of simian sarcoma virus transformed NRK cells. Biochem Biophys Res Commun. 1989 Nov 15; 164(3):1323-30. View in: PubMed

  178. Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters. Proc Natl Acad Sci U S A. 1989 Feb; 86(3):812-6. View in: PubMed

  179. An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity. J Cell Biol. 1989 Jan; 108(1):177-82. View in: PubMed

  180. Characterization of rodent epidermal growth factor receptor transcripts using a mouse genomic probe. Biochem Biophys Res Commun. 1986 Dec 30; 141(3):1109-15. View in: PubMed

  181. Regulation of the epidermal growth factor receptor by growth-modulating agents. Biotechnol Appl Biochem. 1990 Oct; 12(5):473-7. View in: PubMed

  182. An evolutionarily conserved TGF-alpha/insulin-degrading enzyme. Mol Reprod Dev. 1990 Sep; 27(1):54-9. View in: PubMed

  183. Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme. Mol Endocrinol. 1990 Oct; 4(10):1580-91. View in: PubMed

  184. Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2520-4. View in: PubMed

  185. Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes. Endocrinology. 1991 Mar; 128(3):1603-10. View in: PubMed

  186. Regulation of insulin degradation: expression of an evolutionarily conserved insulin-degrading enzyme increases degradation via an intracellular pathway. Mol Endocrinol. 1991 Oct; 5(10):1467-76. View in: PubMed

  187. Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23----q25. Cytogenet Cell Genet. 1991; 57(4):184-6. View in: PubMed

  188. Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor. Cancer Res. 1990 Feb 01; 50(3):533-8. View in: PubMed

  189. Methylprednisolone ameliorates retinal photic injury in rats. Arch Ophthalmol. 1992 Jun; 110(6):857-61. View in: PubMed

  190. Retraction: Oct-3 is a maternal factor required for the first mouse embryonic division. Cell. 1992 May 29; 69(5):724. View in: PubMed

  191. Therapeutic parameters of methylprednisolone treatment for retinal photic injury in a rat model. Res Commun Chem Pathol Pharmacol. 1992 Sep; 77(3):299-311. View in: PubMed

  192. Interactions between retroviruses and environmental carcinogens and their role in animal and human leukemogenesis. Leuk Res. 1992 Nov; 16(11):1061-9. View in: PubMed

  193. Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor. J Biol Chem. 1992 Oct 05; 267(28):19876-83. View in: PubMed

  194. Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity. Toxicon. 1992 Aug; 30(8):873-8. View in: PubMed

  195. Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4373-7. View in: PubMed

  196. Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer. Journal of Experimental Medicine. 2019.::::
© 2023 The University of Chicago | All Rights Reserved.
Facebook Twitter Youtube