Tiwari P, Blank A, Cui C, Schoenfelt KQ, Zhou G, Xu Y, Khramtsova G, Olopade F, Shah AM, Khan SA, Rosner MR, Becker L. Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer. J Exp Med. 2019 Jun 03; 216(6):1345-1358. View in: PubMed
Lee J, Yesilkanal AE, Wynne JP, Frankenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, Nomura DK, Bonini MG, Locasale JW, Rosner MR. Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. Nature. 2019 04; 568(7751):254-258. View in: PubMed
Yesilkanal AE, Rosner MR. Targeting Raf Kinase Inhibitory Protein Regulation and Function. Cancers (Basel). 2018 Sep 04; 10(9). View in: PubMed
Skinner JJ, Wang S, Lee J, Ong C, Sommese R, Sivaramakrishnan S, Koelmel W, Hirschbeck M, Schindelin H, Kisker C, Lorenz K, Sosnick TR, Rosner MR. Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):13453-13458. View in: PubMed
Lorenz K, Rosner MR, Brand T, Schmitt JP. Raf kinase inhibitor protein: lessons of a better way for ß-adrenergic receptor activation in the heart. J Physiol. 2017 06 15; 595(12):4073-4087. View in: PubMed
Chesneau VR, Perlman RK, Li W, Keller GA, Rosner MR. Insulin-Degrading Enzyme Does Not Require Peroxisomal Localization for Insulin Degradation. Endocrinology. 1997 Aug 01; 138(8):3444-3451. View in: PubMed
Bainer R, Frankenberger C, Rabe D, An G, Gilad Y, Rosner MR. Gene expression in local stroma reflects breast tumor states and predicts patient outcome. Sci Rep. 2016 12 16; 6:39240. View in: PubMed
Wang X, Chow CR, Ebine K, Lee J, Rosner MR, Pan T, Munshi HG. Interaction of tRNA with MEK2 in pancreatic cancer cells. Sci Rep. 2016 06 15; 6:28260. View in: PubMed
Frankenberger C, Rabe D, Bainer R, Sankarasharma D, Chada K, Krausz T, Gilad Y, Becker L, Rosner MR. Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages. Cancer Res. 2015 Oct 01; 75(19):4063-73. View in: PubMed
Lee U, Skinner JJ, Reinitz J, Rosner MR, Kim EJ. Noise-Driven Phenotypic Heterogeneity with Finite Correlation Time in Clonal Populations. PLoS One. 2015; 10(7):e0132397. View in: PubMed
Skinner JJ, Rosner MR. RKIP structure drives its function: a three-state model for regulation of RKIP. Crit Rev Oncog. 2014; 19(6):483-8. View in: PubMed
Yesilkanal AE, Rosner MR. Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer. Crit Rev Oncog. 2014; 19(6):447-54. View in: PubMed
Lawlor PN, Kalisky T, Rosner R, Rosner MR, Kording KP. Conceptualizing cancer drugs as classifiers. PLoS One. 2014; 9(9):e106444. View in: PubMed
Lee J, Lee J, Farquhar KS, Yun J, Frankenberger CA, Bevilacqua E, Yeung K, Kim EJ, Balázsi G, Rosner MR. Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):E364-73. View in: PubMed
Lee U, Frankenberger C, Yun J, Bevilacqua E, Caldas C, Chin SF, Rueda OM, Reinitz J, Rosner MR. A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients. PLoS One. 2013; 8(12):e82125. View in: PubMed
Sun M, Gomes S, Chen P, Frankenberger CA, Sankarasharma D, Chung CH, Chada KK, Rosner MR. RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2. Oncogene. 2014 Jul 03; 33(27):3528-37. View in: PubMed
Sun M, Song CX, Huang H, Frankenberger CA, Sankarasharma D, Gomes S, Chen P, Chen J, Chada KK, He C, Rosner MR. HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9920-5. View in: PubMed
Martinho O, Pinto F, Granja S, Miranda-Gonçalves V, Moreira MA, Ribeiro LF, di Loreto C, Rosner MR, Longatto-Filho A, Reis RM. RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy. PLoS One. 2013; 8(3):e59104. View in: PubMed
Pavon-Eternod M, Gomes S, Rosner MR, Pan T. Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells. RNA. 2013 Apr; 19(4):461-6. View in: PubMed
Zeng L, Ehrenreiter K, Menon J, Menard R, Kern F, Nakazawa Y, Bevilacqua E, Imamoto A, Baccarini M, Rosner MR. RKIP regulates MAP kinase signaling in cells with defective B-Raf activity. Cell Signal. 2013 May; 25(5):1156-65. View in: PubMed
Menon J, Doebele RC, Gomes S, Bevilacqua E, Reindl KM, Rosner MR. A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer. PLoS One. 2012; 7(11):e49893. View in: PubMed
Zhou DH, Lee J, Frankenberger C, Geslain R, Rosner M, Pan T. Anti-tumor effects of an engineered "killer" transfer RNA. Biochem Biophys Res Commun. 2012 Oct 12; 427(1):148-53. View in: PubMed
Minn AJ, Bevilacqua E, Yun J, Rosner MR. Identification of novel metastasis suppressor signaling pathways for breast cancer. Cell Cycle. 2012 Jul 01; 11(13):2452-7. View in: PubMed
Frank SA, Rosner MR. Nonheritable cellular variability accelerates the evolutionary processes of cancer. PLoS Biol. 2012; 10(4):e1001296. View in: PubMed
Bevilacqua E, Frankenberger CA, Rosner MR. RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes. Int J Breast Cancer. 2012; 2012:124704. View in: PubMed
Ansari AZ, Rosner MR, Adler J. Har Gobind Khorana 1922-2011. Cell. 2011 Dec 23; 147(7):1433-5. View in: PubMed
Martinho O, Granja S, Jaraquemada T, Caeiro C, Miranda-Gonçalves V, Honavar M, Costa P, Damasceno M, Rosner MR, Lopes JM, Reis RM. Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas. PLoS One. 2012; 7(1):e30769. View in: PubMed
Siu KT, Rosner MR, Minella AC. An integrated view of cyclin E function and regulation. Cell Cycle. 2012 Jan 01; 11(1):57-64. View in: PubMed
Gundacker C, Scheinast M, Damjanovic L, Fuchs C, Rosner M, Hengstschläger M. Proliferation potential of human amniotic fluid stem cells differently responds to mercury and lead exposure. Amino Acids. 2012 Aug; 43(2):937-49. View in: PubMed
Yun J, Frankenberger CA, Kuo WL, Boelens MC, Eves EM, Cheng N, Liang H, Li WH, Ishwaran H, Minn AJ, Rosner MR. Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer. EMBO J. 2011 Aug 26; 30(21):4500-14. View in: PubMed
Rosner M, Schipany K, Hengstschläger M. p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6. Amino Acids. 2012 Jun; 42(6):2251-6. View in: PubMed
Rosner M, Hengstschläger M. Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR. Oncogene. 2011 Nov 03; 30(44):4509-22. View in: PubMed
Liu J, Kuo WL, Seiwert TY, Lingen M, Ciaccio MF, Jones RB, Rosner MR, Cohen EE. Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin. Head Neck. 2011 Dec; 33(12):1774-82. View in: PubMed
Kuo WL, Liu J, Mauceri H, Vokes EE, Weichselbaum R, Rosner MR, Cohen EE. Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context. Mol Cancer Ther. 2010 Oct; 9(10):2814-24. View in: PubMed
Eves EM, Rosner MR. MAP kinase regulation of the mitotic spindle checkpoint. Methods Mol Biol. 2010; 661:497-505. View in: PubMed
Rosner M, Fuchs C, Dolznig H, Hengstschläger M. Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236. Amino Acids. 2011 Feb; 40(2):595-600. View in: PubMed
Rosner M, Hengstschläger M. Evidence for cell cycle-dependent, rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244. Amino Acids. 2010 Nov; 39(5):1487-92. View in: PubMed
Shemon AN, Heil GL, Granovsky AE, Clark MM, McElheny D, Chimon A, Rosner MR, Koide S. Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands. PLoS One. 2010 May 05; 5(5):e10479. View in: PubMed
Netzer N, Goodenbour JM, David A, Dittmar KA, Jones RB, Schneider JR, Boone D, Eves EM, Rosner MR, Gibbs JS, Embry A, Dolan B, Das S, Hickman HD, Berglund P, Bennink JR, Yewdell JW, Pan T. Innate immune and chemically triggered oxidative stress modifies translational fidelity. Nature. 2009 Nov 26; 462(7272):522-6. View in: PubMed
Valli A, Rosner M, Fuchs C, Siegel N, Bishop CE, Dolznig H, Mädel U, Feichtinger W, Atala A, Hengstschläger M. Embryoid body formation of human amniotic fluid stem cells depends on mTOR. Oncogene. 2010 Feb 18; 29(7):966-77. View in: PubMed
Pavon-Eternod M, Gomes S, Geslain R, Dai Q, Rosner MR, Pan T. tRNA over-expression in breast cancer and functional consequences. Nucleic Acids Res. 2009 Nov; 37(21):7268-80. View in: PubMed
Rosner M, Dolznig H, Fuchs C, Siegel N, Valli A, Hengstschläger M. CDKs as therapeutic targets for the human genetic disease tuberous sclerosis? Eur J Clin Invest. 2009 Dec; 39(12):1033-5. View in: PubMed
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR. A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. Blood. 2009 Nov 12; 114(20):4592-600. View in: PubMed
Cohen EE, Rosner MR. MicroRNA-regulated feed forward loop network. Cell Cycle. 2009 Aug 15; 8(16):2477-8. View in: PubMed
Chou YH, Kuo WL, Rosner MR, Tang WJ, Goldman RD. Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme. FASEB J. 2009 Nov; 23(11):3734-42. View in: PubMed
Shemon AN, Eves EM, Clark MC, Heil G, Granovsky A, Zeng L, Imamoto A, Koide S, Rosner MR. Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. PLoS One. 2009 Jun 24; 4(6):e6028. View in: PubMed
Dangi-Garimella S, Yun J, Eves EM, Newman M, Erkeland SJ, Hammond SM, Minn AJ, Rosner MR. Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J. 2009 Feb 18; 28(4):347-58. View in: PubMed
Rosner M, Siegel N, Valli A, Fuchs C, Hengstschläger M. mTOR phosphorylated at S2448 binds to raptor and rictor. Amino Acids. 2010 Jan; 38(1):223-8. View in: PubMed
Cohen EE, Zhu H, Lingen MW, Martin LE, Kuo WL, Choi EA, Kocherginsky M, Parker JS, Chung CH, Rosner MR. A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. Cancer Res. 2009 Jan 01; 69(1):65-74. View in: PubMed
Granovsky AE, Clark MC, McElheny D, Heil G, Hong J, Liu X, Kim Y, Joachimiak G, Joachimiak A, Koide S, Rosner MR. Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism. Mol Cell Biol. 2009 Mar; 29(5):1306-20. View in: PubMed
Yfanti C, Mengele K, Gkazepis A, Weirich G, Giersig C, Kuo WL, Tang WJ, Rosner M, Schmitt M. Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues. Int J Mol Med. 2008 Oct; 22(4):421-31. View in: PubMed
Weirich G, Mengele K, Yfanti C, Gkazepis A, Hellmann D, Welk A, Giersig C, Kuo WL, Rosner MR, Tang WJ, Schmitt M. Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines. Biol Chem. 2008 Nov; 389(11):1441-5. View in: PubMed
Zeng L, Imamoto A, Rosner MR. Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target. Expert Opin Ther Targets. 2008 Oct; 12(10):1275-87. View in: PubMed
Burgstaller S, Rosner M, Lindengrün C, Hanneder M, Siegel N, Valli A, Fuchs C, Hengstschläger M. Tuberin, p27 and mTOR in different cells. Amino Acids. 2009 Feb; 36(2):297-302. View in: PubMed
Granovsky AE, Rosner MR. Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor. Cell Res. 2008 Apr; 18(4):452-7. View in: PubMed
Hudelist G, Wagner T, Rosner M, Fink-Retter A, Gschwantler-Kaulich D, Czerwenka K, Kroiss R, Tea M, Pischinger K, Köstler WJ, Attems J, Mueller R, Blaukopf C, Kubista E, Hengstschläger M, Singer CF. Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations. Endocr Relat Cancer. 2007 Dec; 14(4):1053-62. View in: PubMed
Freilinger A, Rosner M, Hanneder M, Hengstschläger M. Ras mediates cell survival by regulating tuberin. Oncogene. 2008 Mar 27; 27(14):2072-83. View in: PubMed
Hong J, Doebele RC, Lingen MW, Quilliam LA, Tang WJ, Rosner MR. Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1. J Biol Chem. 2007 Jul 06; 282(27):19781-7. View in: PubMed
Rosner M, Hengstschläger M. Cytoplasmic/nuclear localization of tuberin in different cell lines. Amino Acids. 2007 Nov; 33(4):575-9. View in: PubMed
Rosner M, Hanneder M, Freilinger A, Hengstschläger M. Nuclear/cytoplasmic localization of Akt activity in the cell cycle. Amino Acids. 2007; 32(3):341-5. View in: PubMed
Rosner MR. MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation. Cell Div. 2007 Jan 10; 2:1. View in: PubMed
Radulescu RT, Hufnagel C, Luppa P, Hellebrand H, Kuo WL, Rosner MR, Harbeck N, Giersig C, Meindl A, Schmitt M, Weirich G. Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels. Int J Oncol. 2007 Jan; 30(1):73-80. View in: PubMed
Shen Y, Joachimiak A, Rosner MR, Tang WJ. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature. 2006 Oct 19; 443(7113):870-4. View in: PubMed
Eves EM, Shapiro P, Naik K, Klein UR, Trakul N, Rosner MR. Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Mol Cell. 2006 Aug; 23(4):561-74. View in: PubMed
Rosner M, Freilinger A, Hengstschläger M. Akt regulates nuclear/cytoplasmic localization of tuberin. Oncogene. 2007 Jan 25; 26(4):521-31. View in: PubMed
Cohen EE, Lingen MW, Zhu B, Zhu H, Straza MW, Pierce C, Martin LE, Rosner MR. Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cancer Res. 2006 Jun 15; 66(12):6296-303. View in: PubMed
Freilinger A, Rosner M, Hengstschläger M. Tuberin negatively affects BCL-2's cell survival function. Amino Acids. 2006 Jun; 30(4):391-6. View in: PubMed
Freilinger A, Rosner M, Krupitza G, Nishino M, Lubec G, Korsmeyer SJ, Hengstschläger M. Tuberin activates the proapoptotic molecule BAD. Oncogene. 2006 Oct 19; 25(49):6467-79. View in: PubMed
Li P, Kuo WL, Yousef M, Rosner MR, Tang WJ. The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition. Biochem Biophys Res Commun. 2006 May 19; 343(4):1032-7. View in: PubMed
Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A. NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell. 2006 Feb 17; 21(4):467-80. View in: PubMed
Clark MC, McElheny D, Wojcik J, Kurutz J, Rosner MR, Koide S. NMR assignment of rat Raf kinase inhibitor protein. J Biomol NMR. 2006; 36 Suppl 1:4. View in: PubMed
Lin C, Franco B, Rosner MR. CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders. Hum Mol Genet. 2005 Dec 15; 14(24):3775-86. View in: PubMed
Rosner M, Hengstschläger M. 14-3-3 proteins are involved in the regulation of mammalian cell proliferation. Amino Acids. 2006 Feb; 30(1):105-9. View in: PubMed
Hong J, Beeler J, Zhukovskaya NL, He W, Tang WJ, Rosner MR. Anthrax edema factor potency depends on mode of cell entry. Biochem Biophys Res Commun. 2005 Sep 30; 335(3):850-7. View in: PubMed
Trakul N, Menard RE, Schade GR, Qian Z, Rosner MR. Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. J Biol Chem. 2005 Jul 01; 280(26):24931-40. View in: PubMed
Trakul N, Rosner MR. Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein. Cell Res. 2005 Jan; 15(1):19-23. View in: PubMed
Rosner M, Freilinger A, Hengstschläger M. Proteins interacting with the tuberous sclerosis gene products. Amino Acids. 2004 Oct; 27(2):119-28. View in: PubMed
Kuo WL, Duke CJ, Abe MK, Kaplan EL, Gomes S, Rosner MR. ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway. J Biol Chem. 2004 May 28; 279(22):23073-81. View in: PubMed
Zhou L, Li J, Goldsmith AM, Newcomb DC, Giannola DM, Vosk RG, Eves EM, Rosner MR, Solway J, Hershenson MB. Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma. Am J Respir Crit Care Med. 2004 Mar 15; 169(6):703-11. View in: PubMed
Pugazhenthi S, Nesterova A, Jambal P, Audesirk G, Kern M, Cabell L, Eves E, Rosner MR, Boxer LM, Reusch JE. Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons. J Neurochem. 2003 Mar; 84(5):982-96. View in: PubMed
Corbit KC, Trakul N, Eves EM, Diaz B, Marshall M, Rosner MR. Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J Biol Chem. 2003 Apr 11; 278(15):13061-8. View in: PubMed
Tang F, Tang G, Xiang J, Dai Q, Rosner MR, Lin A. The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol. 2002 Dec; 22(24):8571-9. View in: PubMed
Page K, Li J, Corbit KC, Rumilla KM, Soh JW, Weinstein IB, Albanese C, Pestell RG, Rosner MR, Hershenson MB. Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta. Am J Respir Cell Mol Biol. 2002 Aug; 27(2):204-13. View in: PubMed
Hong J, Yoshida K, Rosner MR. Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation. J Neurochem. 2002 Jun; 81(5):922-34. View in: PubMed
Abe MK, Saelzler MP, Espinosa R, Kahle KT, Hershenson MB, Le Beau MM, Rosner MR. ERK8, a new member of the mitogen-activated protein kinase family. J Biol Chem. 2002 May 10; 277(19):16733-43. View in: PubMed
Soucek T, Rosner M, Miloloza A, Kubista M, Cheadle JP, Sampson JR, Hengstschläger M. Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression. Oncogene. 2001 Aug 09; 20(35):4904-9. View in: PubMed
Eves EM, Skoczylas C, Yoshida K, Alnemri ES, Rosner MR. FGF induces a switch in death receptor pathways in neuronal cells. J Neurosci. 2001 Jul 15; 21(14):4996-5006. View in: PubMed
Hengstschläger M, Rodman DM, Miloloza A, Hengstschläger-Ottnad E, Rosner M, Kubista M. Tuberous sclerosis gene products in proliferation control. Mutat Res. 2001 Jul; 488(3):233-9. View in: PubMed
Qian Z, Lin C, Espinosa R, LeBeau M, Rosner MR. Cloning and characterization of MST4, a novel Ste20-like kinase. J Biol Chem. 2001 Jun 22; 276(25):22439-45. View in: PubMed
Abe MK, Kahle KT, Saelzler MP, Orth K, Dixon JE, Rosner MR. ERK7 is an autoactivated member of the MAPK family. J Biol Chem. 2001 Jun 15; 276(24):21272-9. View in: PubMed
Janulis M, Trakul N, Greene G, Schaefer EM, Lee JD, Rosner MR. A novel mitogen-activated protein kinase is responsive to Raf and mediates growth factor specificity. Mol Cell Biol. 2001 Mar; 21(6):2235-47. View in: PubMed
Chesneau V, Vekrellis K, Rosner MR, Selkoe DJ. Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization. Biochem J. 2000 Oct 15; 351 Pt 2:509-16. View in: PubMed
Miloloza A, Rosner M, Nellist M, Halley D, Bernaschek G, Hengstschläger M. The TSC1 gene product, hamartin, negatively regulates cell proliferation. Hum Mol Genet. 2000 Jul 22; 9(12):1721-7. View in: PubMed
Corbit KC, Soh JW, Yoshida K, Eves EM, Weinstein IB, Rosner MR. Different protein kinase C isoforms determine growth factor specificity in neuronal cells. Mol Cell Biol. 2000 Aug; 20(15):5392-403. View in: PubMed
Chesneau V, Rosner MR. Functional human insulin-degrading enzyme can be expressed in bacteria. Protein Expr Purif. 2000 Jun; 19(1):91-8. View in: PubMed
Morrione A, Romano G, Navarro M, Reiss K, Valentinis B, Dews M, Eves E, Rosner MR, Baserga R. Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells. Cancer Res. 2000 Apr 15; 60(8):2263-72. View in: PubMed
Chao KS, Hsu JS, Xu J, Ezekiel UR, Eves E, Rosner M, Hsu CY. Differential effect of cycloheximide on neuronal and glioma cells treated with chemotherapy and radiation. J Neurooncol. 1999; 45(1):19-26. View in: PubMed
Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000 Mar 01; 20(5):1657-65. View in: PubMed
Gomes I, Xiong W, Miki T, Rosner MR. A proline- and glutamine-rich protein promotes apoptosis in neuronal cells. J Neurochem. 1999 Aug; 73(2):612-22. View in: PubMed
Page K, Li J, Hodge JA, Liu PT, Vanden Hoek TL, Becker LB, Pestell RG, Rosner MR, Hershenson MB. Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells. J Biol Chem. 1999 Jul 30; 274(31):22065-71. View in: PubMed
Corbit KC, Foster DA, Rosner MR. Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells. Mol Cell Biol. 1999 Jun; 19(6):4209-18. View in: PubMed
Abe MK, Kuo WL, Hershenson MB, Rosner MR. Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth. Mol Cell Biol. 1999 Feb; 19(2):1301-12. View in: PubMed
Qian Z, Okuhara D, Abe MK, Rosner MR. Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel. J Biol Chem. 1999 Jan 15; 274(3):1621-7. View in: PubMed
Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem. 1998 Dec 04; 273(49):32730-8. View in: PubMed
Chung KC, Gomes I, Wang D, Lau LF, Rosner MR. Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways. Mol Cell Biol. 1998 Apr; 18(4):2272-81. View in: PubMed
Eves EM, Xiong W, Bellacosa A, Kennedy SG, Tsichlis PN, Rosner MR, Hay N. Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Mol Cell Biol. 1998 Apr; 18(4):2143-52. View in: PubMed
Xiong W, Pestell R, Rosner MR. Role of cyclins in neuronal differentiation of immortalized hippocampal cells. Mol Cell Biol. 1997 Nov; 17(11):6585-97. View in: PubMed
Chao TS, Abe M, Hershenson MB, Gomes I, Rosner MR. Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin. Cancer Res. 1997 Aug 01; 57(15):3168-73. View in: PubMed
Kuo WL, Chung KC, Rosner MR. Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src. Mol Cell Biol. 1997 Aug; 17(8):4633-43. View in: PubMed
Chesneau V, Perlman RK, Li W, Keller GA, Rosner MR. Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation. Endocrinology. 1997 Aug; 138(8):3444-51. View in: PubMed
Xiong W, Pestell RG, Watanabe G, Li J, Rosner MR, Hershenson MB. Cyclin D1 is required for S phase traversal in bovine tracheal myocytes. Am J Physiol. 1997 Jun; 272(6 Pt 1):L1205-10. View in: PubMed
Singh BS, Rajakumar PA, Eves EM, Rosner MR, Wainer BH, Devaskar SU. Insulin gene expression in immortalized rat hippocampal and pheochromocytoma-12 cell lines. Regul Pept. 1997 Mar 12; 69(1):7-14. View in: PubMed
Hamel FG, Gehm BD, Rosner MR, Duckworth WC. Identification of the cleavage sites of transforming growth factor alpha by insulin-degrading enzymes. Biochim Biophys Acta. 1997 Apr 04; 1338(2):207-14. View in: PubMed
Morrison P, Chung KC, Rosner MR. Mutation of Di-leucine residues in the juxtamembrane region alters EGF receptor expression. Biochemistry. 1996 Nov 19; 35(46):14618-24. View in: PubMed
Eves EM, Boise LH, Thompson CB, Wagner AJ, Hay N, Rosner MR. Apoptosis induced by differentiation or serum deprivation in an immortalized central nervous system neuronal cell line. J Neurochem. 1996 Nov; 67(5):1908-20. View in: PubMed
Morrison P, Saltiel AR, Rosner MR. Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C. J Biol Chem. 1996 May 31; 271(22):12891-6. View in: PubMed
Kuo WL, Abe M, Rhee J, Eves EM, McCarthy SA, Yan M, Templeton DJ, McMahon M, Rosner MR. Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells. Mol Cell Biol. 1996 Apr; 16(4):1458-70. View in: PubMed
Gehm BD, Kuo WL, Perlman RK, Rosner MR. Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding. J Biol Chem. 1993 Apr 15; 268(11):7943-8. View in: PubMed
Qian D, Griswold-Prenner I, Rosner MR, Fitch FW. Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation. J Biol Chem. 1993 Feb 25; 268(6):4488-93. View in: PubMed
Morrison P, Takishima K, Rosner MR. Role of threonine residues in regulation of the epidermal growth factor receptor by protein kinase C and mitogen-activated protein kinase. J Biol Chem. 1993 Jul 25; 268(21):15536-43. View in: PubMed
Griswold-Prenner I, Carlin CR, Rosner MR. Mitogen-activated protein kinase regulates the epidermal growth factor receptor through activation of a tyrosine phosphatase. J Biol Chem. 1993 Jun 25; 268(18):13050-4. View in: PubMed
Rosner M, Bobak P, Lam TL. Corneal electrode for recording electroretinograms in rats. Doc Ophthalmol. 1993; 83(2):175-80. View in: PubMed
Hou X, Johnson AC, Rosner MR. Identification of an epidermal growth factor receptor transcriptional repressor. J Biol Chem. 1994 Feb 11; 269(6):4307-12. View in: PubMed
Tucker MS, Khan I, Fuchs-Young R, Price S, Steininger TL, Greene G, Wainer BH, Rosner MR. Localization of immunoreactive epidermal growth factor receptor in neonatal and adult rat hippocampus. Brain Res. 1993 Dec 17; 631(1):65-71. View in: PubMed
Hoffman BL, Takishima K, Rosner MR, Carlin C. Adenovirus and protein kinase C have distinct molecular requirements for regulating epidermal growth factor receptor trafficking. J Cell Physiol. 1993 Dec; 157(3):535-43. View in: PubMed
Rosen N, Ashkenazi I, Rosner M. Patient dissatisfaction after functionally successful conjunctivodacryocystorhinostomy with Jones tube. Am J Ophthalmol. 1994 May 15; 117(5):636-42. View in: PubMed
Chao TS, Foster DA, Rapp UR, Rosner MR. Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium. J Biol Chem. 1994 Mar 11; 269(10):7337-41. View in: PubMed
Perlman RK, Gehm BD, Kuo WL, Rosner MR. Functional analysis of conserved residues in the active site of insulin-degrading enzyme. J Biol Chem. 1993 Oct 15; 268(29):21538-44. View in: PubMed
Kuo WL, Gehm BD, Rosner MR, Li W, Keller G. Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line. J Biol Chem. 1994 Sep 09; 269(36):22599-606. View in: PubMed
Hou X, Johnson AC, Rosner MR. Induction of epidermal growth factor receptor gene transcription by transforming growth factor beta 1: association with loss of protein binding to a negative regulatory element. Cell Growth Differ. 1994 Aug; 5(8):801-9. View in: PubMed
Abe MK, Chao TS, Solway J, Rosner MR, Hershenson MB. Hydrogen peroxide stimulates mitogen-activated protein kinase in bovine tracheal myocytes: implications for human airway disease. Am J Respir Cell Mol Biol. 1994 Nov; 11(5):577-85. View in: PubMed
Eves EM, Kwon J, Downen M, Tucker MS, Wainer BH, Rosner MR. Conditional immortalization of neuronal cells from postmitotic cultures and adult CNS. Brain Res. 1994 Sep 12; 656(2):396-404. View in: PubMed
Perlman RK, Rosner MR. Identification of zinc ligands of the insulin-degrading enzyme. J Biol Chem. 1994 Dec 30; 269(52):33140-5. View in: PubMed
Tucker MS, Eves EM, Wainer BH, Rosner MR. Activation of mitogen-activated protein kinase by epidermal growth factor in hippocampal neurons and neuronal cell lines. J Neurochem. 1993 Oct; 61(4):1376-87. View in: PubMed
Kuo WL, Montag AG, Rosner MR. Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues. Endocrinology. 1993 Feb; 132(2):604-11. View in: PubMed
Hershenson MB, Chao TS, Abe MK, Gomes I, Kelleher MD, Solway J, Rosner MR. Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells. J Biol Chem. 1995 Aug 25; 270(34):19908-13. View in: PubMed
Kelleher MD, Abe MK, Chao TS, Jain M, Green JM, Solway J, Rosner MR, Hershenson MB. Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis. Am J Physiol. 1995 Jun; 268(6 Pt 1):L894-901. View in: PubMed
Englert C, Hou X, Maheswaran S, Bennett P, Ngwu C, Re GG, Garvin AJ, Rosner MR, Haber DA. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J. 1995 Oct 02; 14(19):4662-75. View in: PubMed
Rosner MR, Hubbard SC, Ivatt RJ, Robbins PW. N-asparagine-linked oligosaccharides: biosynthesis of the lipid-linked oligosaccharides. Methods Enzymol. 1982; 83:399-408. View in: PubMed
Rosner MR, Tung JS, Hopkins N, Robbins PW. Relationship of GIX antigen expression to the glycosylation of murine leukemia virus glycoprotein. Proc Natl Acad Sci U S A. 1980 Nov; 77(11):6420-4. View in: PubMed
Hsieh P, Rosner MR, Robbins PW. Host-dependent variation of asparagine-linked oligosaccharides at individual glycosylation sites of Sindbis virus glycoproteins. J Biol Chem. 1983 Feb 25; 258(4):2548-54. View in: PubMed
Hsieh P, Rosner MR, Robbins PW. Selective cleavage by endo-beta-N-acetylglucosaminidase H at individual glycosylation sites of Sindbis virion envelope glycoproteins. J Biol Chem. 1983 Feb 25; 258(4):2555-61. View in: PubMed
Friedman B, Frackelton AR, Ross AH, Connors JM, Fujiki H, Sugimura T, Rosner MR. Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. Proc Natl Acad Sci U S A. 1984 May; 81(10):3034-8. View in: PubMed
McCaffrey PG, Friedman B, Rosner MR. Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor. J Biol Chem. 1984 Oct 25; 259(20):12502-7. View in: PubMed
Johnson PA, Rosner MR. Characterization of murine-specific leukemia virus receptor from L cells. J Virol. 1986 Jun; 58(3):900-8. View in: PubMed
Blackshear PJ, Stumpo DJ, Kennington EA, Tuttle JS, Orth DN, Thompson KL, Hung MC, Rosner MR. Decreased levels of hepatic epidermal growth factor receptors in obese hyperglycemic rodents. J Biol Chem. 1987 Sep 05; 262(25):12356-64. View in: PubMed
Friedman BA, Rosner MR. Growth factors modify the epidermal growth factor receptor through multiple pathways. J Cell Biochem. 1987 May; 34(1):1-11. View in: PubMed
McCaffrey P, Ran W, Campisi J, Rosner MR. Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells. J Biol Chem. 1987 Feb 05; 262(4):1442-5. View in: PubMed
McCaffrey PG, Rosner MR. Growth state-dependent regulation of protein kinase C in normal and transformed murine cells. Cancer Res. 1987 Feb 15; 47(4):1081-6. View in: PubMed
McCaffrey PG, Rosner MR, Kikkawa U, Sekiguchi K, Ogita K, Ase K, Nishizuka Y. Characterization of protein kinase C from normal and transformed cultured murine fibroblasts. Biochem Biophys Res Commun. 1987 Jul 15; 146(1):140-6. View in: PubMed
Takishima K, Friedman B, Fujiki H, Rosner MR. Thapsigargin, a novel promoter, phosphorylates the epidermal growth factor receptor at threonine 669. Biochem Biophys Res Commun. 1988 Dec 15; 157(2):740-6. View in: PubMed
Thompson KL, Assoian R, Rosner MR. Transforming growth factor-beta increases transcription of the genes encoding the epidermal growth factor receptor and fibronectin in normal rat kidney fibroblasts. J Biol Chem. 1988 Dec 25; 263(36):19519-24. View in: PubMed
Garcia JV, Fenton BW, Rosner MR. Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster. Biochemistry. 1988 Jun 14; 27(12):4237-44. View in: PubMed
Stoppelli MP, Garcia JV, Decker SJ, Rosner MR. Developmental regulation of an insulin-degrading enzyme from Drosophila melanogaster. Proc Natl Acad Sci U S A. 1988 May; 85(10):3469-73. View in: PubMed
Garcia JV, Stoppelli MP, Thompson KL, Decker SJ, Rosner MR. Characterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors. J Cell Biol. 1987 Jul; 105(1):449-56. View in: PubMed
Thompson KL, Decker SJ, Rosner MR. Identification of a novel receptor in Drosophila for both epidermal growth factor and insulin. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8443-7. View in: PubMed
Wattenberg EV, Fujiki H, Rosner MR. Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter. Cancer Res. 1987 Sep 01; 47(17):4618-22. View in: PubMed
Hicks K, Friedman B, Rosner MR. Basic and acidic fibroblast growth factors modulate the epidermal growth factor receptor by a protein kinase C-independent pathway. Biochem Biophys Res Commun. 1989 Oct 31; 164(2):796-803. View in: PubMed
Thompson KL, Rosner MR. Regulation of epidermal growth factor receptor gene expression by retinoic acid and epidermal growth factor. J Biol Chem. 1989 Feb 25; 264(6):3230-4. View in: PubMed
Keith LG, MacGregor S, Friedell S, Rosner M, Chasnoff IJ, Sciarra JJ. Substance abuse in pregnant women: recent experience at the Perinatal Center for Chemical Dependence of Northwestern Memorial Hospital. Obstet Gynecol. 1989 May; 73(5 Pt 1):715-20. View in: PubMed
Assia E, Rosner M, Belkin M, Solomon A, Schwartz M. Temporal parameters of low energy laser irradiation for optimal delay of post-traumatic degeneration of rat optic nerve. Brain Res. 1989 Jan 09; 476(2):205-12. View in: PubMed
Garcia JV, Gehm BD, Rosner MR. An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin. J Cell Biol. 1989 Sep; 109(3):1301-7. View in: PubMed
Duckworth WC, Garcia JV, Liepnieks JJ, Hamel FG, Hermodson MA, Frank BH, Rosner MR. Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites. Biochemistry. 1989 Mar 21; 28(6):2471-7. View in: PubMed
Wattenberg EV, Uemura D, Byron KL, Villereal ML, Fujiki H, Rosner MR. Structure-activity studies of the nonphorbol tumor promoter palytoxin in Swiss 3T3 cells. Cancer Res. 1989 Nov 01; 49(21):5837-42. View in: PubMed
Wattenberg EV, Byron KL, Villereal ML, Fujiki H, Rosner MR. Sodium as a mediator of non-phorbol tumor promoter action. Down-modulation of the epidermal growth factor receptor by palytoxin. J Biol Chem. 1989 Sep 05; 264(25):14668-73. View in: PubMed
Wattenberg EV, McNeil PL, Fujiki H, Rosner MR. Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway. J Biol Chem. 1989 Jan 05; 264(1):213-9. View in: PubMed
Hicks K, Friedman B, Rosner MR. Basic fibroblast-like growth factor is present in the conditioned medium of simian sarcoma virus transformed NRK cells. Biochem Biophys Res Commun. 1989 Nov 15; 164(3):1323-30. View in: PubMed
Friedman BA, van Amsterdam J, Fujiki H, Rosner MR. Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters. Proc Natl Acad Sci U S A. 1989 Feb; 86(3):812-6. View in: PubMed
Garcia JV, Stoppelli MP, Decker SJ, Rosner MR. An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity. J Cell Biol. 1989 Jan; 108(1):177-82. View in: PubMed
Hung MC, Thompson KL, Chiu IM, Rosner MR. Characterization of rodent epidermal growth factor receptor transcripts using a mouse genomic probe. Biochem Biophys Res Commun. 1986 Dec 30; 141(3):1109-15. View in: PubMed
Rosner MR. Regulation of the epidermal growth factor receptor by growth-modulating agents. Biotechnol Appl Biochem. 1990 Oct; 12(5):473-7. View in: PubMed
Rosner MR. An evolutionarily conserved TGF-alpha/insulin-degrading enzyme. Mol Reprod Dev. 1990 Sep; 27(1):54-9. View in: PubMed
Kuo WL, Gehm BD, Rosner MR. Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme. Mol Endocrinol. 1990 Oct; 4(10):1580-91. View in: PubMed
Takishima K, Griswold-Prenner I, Ingebritsen T, Rosner MR. Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2520-4. View in: PubMed
Gehm BD, Rosner MR. Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes. Endocrinology. 1991 Mar; 128(3):1603-10. View in: PubMed
Kuo WL, Gehm BD, Rosner MR. Regulation of insulin degradation: expression of an evolutionarily conserved insulin-degrading enzyme increases degradation via an intracellular pathway. Mol Endocrinol. 1991 Oct; 5(10):1467-76. View in: PubMed
Espinosa R, Lemons RS, Perlman RK, Kuo WL, Rosner MR, Le Beau MM. Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23----q25. Cytogenet Cell Genet. 1991; 57(4):184-6. View in: PubMed
Friedman B, Fujiki H, Rosner MR. Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor. Cancer Res. 1990 Feb 01; 50(3):533-8. View in: PubMed
Rosner M, Lam TT, Fu J, Tso MO. Methylprednisolone ameliorates retinal photic injury in rats. Arch Ophthalmol. 1992 Jun; 110(6):857-61. View in: PubMed
Rosner M, De Santo RJ, Arnheiter H, Staudt LM. Retraction: Oct-3 is a maternal factor required for the first mouse embryonic division. Cell. 1992 May 29; 69(5):724. View in: PubMed
Rosner M, Lam TT, Tso MO. Therapeutic parameters of methylprednisolone treatment for retinal photic injury in a rat model. Res Commun Chem Pathol Pharmacol. 1992 Sep; 77(3):299-311. View in: PubMed
Aboud M, Rosner M, Dombrovsky A, Revazova T, Feldman G, Tolpolar L, Strilitz-Hassan Y, Flügel RM. Interactions between retroviruses and environmental carcinogens and their role in animal and human leukemogenesis. Leuk Res. 1992 Nov; 16(11):1061-9. View in: PubMed
Chao TS, Byron KL, Lee KM, Villereal M, Rosner MR. Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor. J Biol Chem. 1992 Oct 05; 267(28):19876-83. View in: PubMed
Suganuma M, Fujiki H, Okabe S, Nishiwaki S, Brautigan D, Ingebritsen TS, Rosner MR. Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity. Toxicon. 1992 Aug; 30(8):873-8. View in: PubMed
Eves EM, Tucker MS, Roback JD, Downen M, Rosner MR, Wainer BH. Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4373-7. View in: PubMed
Tiwari P, Blank A, Cui C, Schoenfelt KQ, Zhou G, Xu Y, Khramtsova G, Olopade F, Shah AM, Khan SA, Rosner MR, Becker L . Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer. Journal of Experimental Medicine. 2019.::::