The major goal of the laboratory is to dissect and pharmacologically target intracellular proteins to induce cancer cell death and manipulate the immune response. We are currently applying new research tools and prototype therapeutics that we, and others, have developed to target the BCL-2 family of proteins and other cell signaling proteins in immune cells.
A large part of our lab focuses on using portions of the actual proteins, or peptides, as drugs and biological tools to uncover specific molecular pathways in diseased and normal cells. Peptide-based therapeutics have enormous potential for immune modulation and direct cancer treatment but have traditionally lacked efficient stabilization and delivery within patients, and thereby, have had limited clinical applications. To are working to overcome these barriers within the lab and through collaboration with nanotechnologists and chemical engineers.
Overall, we are committed to translation of our findings to pediatric and adult patients with cancer and immune system disease. While performing research at the University of Chicago, we are in close proximity to scientists, clinicians, and patients and are deeply committed to working collaboratively with these groups to make significant inroads in treating those suffering from refractory disease.
James L. LaBelle, MD PhD
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Associate Professor of Pediatrics
Committee on Cancer Biology - Clinical Interests: Adolescent and Young Adult Cancer Care, Childhood Leukemia, Leukemia, Lymphoma, Pediatric CAR TCell Therapy, Pediatric Hematology, Pediatric Oncology, Stem cell transplantation
- Research and Scholarly Interests: bcl-2 Genes, Graft Versus Host Disease, Immunomodulatory Therapies, Regulatory T Cells
- Websites: LaBelle Lab, Research Network Profile
- Contact: jlabelle1@uchicago.edu
- Graduate Program: Cancer Biology