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Eugene B. Chang

Professor
ebchang@uchicago.edu
Research Summary
The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome. For more information, visit my laboratory website: http://changlab.uchicago.edu/
Keywords
Microbiome, inflammation, mucosal immunity, inflammatory bowel diseases, metabolism
Biosciences Graduate Program Association
Awards & Honors
  • 2008 - 2018 NIH Merit Award National Institutes of Health
  • 2013 - 2017 National Diabetes and Digestive and Kidney Disease Advisory Council National Institutes of Health
  • 2013 - AGA Academy of Educators American Gastroenterological Association
  • 2013 - AGA Outstanding Mentorship award American Gastroenterological Association
  • 2014 - Takeda Distinguished Scientist Award Takeda, Inc.
Publications

  1. Frazier K, Kambal A, Zale EA, Pierre JF, Hubert N, Miyoshi S, Miyoshi J, Ringus DL, Harris D, Yang K, Carroll K, Hermanson JB, Chlystek JS, Overmyer KA, Cham CM, Musch MW, Coon JJ, Chang EB, Leone VA. High-fat diet disrupts REG3? and gut microbial rhythms promoting metabolic dysfunction. Cell Host Microbe. 2022 06 08; 30(6):809-823.e6. View in: PubMed

  2. Zhuo R, Xu M, Wang X, Zhou B, Wu X, Leone V, Chang EB, Zhong X. The regulatory role of N6 -methyladenosine modification in the interaction between host and microbes. Wiley Interdiscip Rev RNA. 2022 Mar 17; e1725. View in: PubMed

  3. Akiyama S, Ollech JE, Traboulsi C, Rai V, Glick LR, Yi Y, Runde J, Olivas AD, Weber CR, Cohen RD, Olortegui KBS, Hurst RD, Umanskiy K, Shogan BD, Rubin MA, Dalal SR, Sakuraba A, Pekow J, Chang EB, Hart J, Hyman NH, Rubin DT. Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis. Dig Dis Sci. 2022 Mar 14. View in: PubMed

  4. Runde J, Erondu A, Akiyama S, Traboulsi C, Rai V, Glick LR, Yi Y, Ollech JE, Cohen RD, Skowron KB, Hurst RD, Umanskiy K, Shogan BD, Hyman NH, Rubin MA, Dalal SR, Sakuraba A, Pekow J, Chang EB, Rubin DT. Outcomes of Ileoanal Pouch Anastomosis in Pediatric Ulcerative Colitis Are Worse in the Modern Era: A Time Trend Analysis Outcomes Following Ileal Pouch-Anal Anastomosis in Pediatric Ulcerative Colitis. Inflamm Bowel Dis. 2022 Jan 18. View in: PubMed

  5. Dodiya HB, Lutz HL, Weigle IQ, Patel P, Michalkiewicz J, Roman-Santiago CJ, Zhang CM, Liang Y, Srinath A, Zhang X, Xia J, Olszewski M, Zhang X, Schipma MJ, Chang EB, Tanzi RE, Gilbert JA, Sisodia SS. Gut microbiota-driven brain Aß amyloidosis in mice requires microglia. J Exp Med. 2022 01 03; 219(1). View in: PubMed

  6. Tang X, Wang P, Zhang R, Watanabe I, Chang E, Vinayachandran V, Nayak L, Lapping S, Liao S, Madera A, Sweet DR, Luo J, Fei J, Jeong HW, Adams RH, Zhang T, Liao X, Jain MK. KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression. J Clin Invest. 2022 02 01; 132(3). View in: PubMed

  7. Cai X, Chen M, Prominski A, Lin Y, Ankenbruck N, Rosenberg J, Nguyen M, Shi J, Tomatsidou A, Randall G, Missiakas D, Fung J, Chang EB, Penaloza-MacMaster P, Tian B, Huang J. A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2. Adv Sci (Weinh). 2022 01; 9(2):e2103240. View in: PubMed

  8. Lee Y, Lee J, Lee MS, Chang E, Kim Y. Chrysanthemum morifolium Flower Extract Ameliorates Obesity-Induced Inflammation and Increases the Muscle Mitochondria Content and AMPK/SIRT1 Activities in Obese Rats. Nutrients. 2021 Oct 19; 13(10). View in: PubMed

  9. Shan Y, Lee M, Chang EB. The Gut Microbiome and Inflammatory Bowel Diseases. Annu Rev Med. 2022 01 27; 73:455-468. View in: PubMed

  10. Dao D, Xie B, Nadeem U, Xiao J, Movahedan A, D'Souza M, Leone V, Hariprasad SM, Chang EB, Sulakhe D, Skondra D. High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota. Cells. 2021 08 18; 10(8). View in: PubMed

  11. Movahedan A, Barba H, Spedale M, Deng N, Arvans D, Nadeem U, Leone V, Chang EB, Theriault B, Skondra D. Gnotobiotic Operations and Assembly for Development of Germ-Free Animal Model of Laser-Induced Choroidal Neovascularization. Transl Vis Sci Technol. 2021 08 02; 10(9):14. View in: PubMed

  12. Liu CY, Cham CM, Chang EB. Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier. Transl Res. 2021 10; 236:35-51. View in: PubMed

  13. Miyoshi J, Miyoshi S, Delmont TO, Cham C, Lee STM, Sakatani A, Yang K, Shan Y, Kennedy M, Kiefl E, Yousef M, Crosson S, Sogin M, Antonopoulos DA, Eren AM, Leone V, Chang EB. Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice. Gastroenterology. 2021 09; 161(3):940-952.e15. View in: PubMed

  14. Choi H, Rao MC, Chang EB. Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism. Nat Rev Gastroenterol Hepatol. 2021 10; 18(10):679-689. View in: PubMed

  15. Chen M, Rosenberg J, Cai X, Lee ACH, Shi J, Nguyen M, Wignakumar T, Mirle V, Edobor AJ, Fung J, Donington JS, Shanmugarajah K, Lin Y, Chang E, Randall G, Penaloza-MacMaster P, Tian B, Madariaga ML, Huang J. Nanotraps for the containment and clearance of SARS-CoV-2. Matter. 2021 Jun 02; 4(6):2059-2082. View in: PubMed

  16. Kennedy MS, Chang EB. The microbiome: Composition and locations. Prog Mol Biol Transl Sci. 2020; 176:1-42. View in: PubMed

  17. Akiyama S, Ollech JE, Rai V, Glick LR, Yi Y, Traboulsi C, Runde J, Cohen RD, Skowron KB, Hurst RD, Umanskiy K, Shogan BD, Hyman NH, Rubin MA, Dalal SR, Sakuraba A, Pekow J, Chang EB, Rubin DT. Endoscopic Phenotype of the J Pouch in Patients With Inflammatory Bowel Disease: A New Classification for Pouch Outcomes. Clin Gastroenterol Hepatol. 2022 02; 20(2):293-302.e9. View in: PubMed

  18. McCormick BA, Chang EB. The Gut Microbiome: Reaching the Promise Through Discovery- Advancing Knowledge and Discovery of the Gut Microbiome in the Age of Precision Medicine. Gastroenterology. 2021 01; 160(2):479-482. View in: PubMed

  19. Cai X, Prominski A, Lin Y, Ankenbruck N, Rosenberg J, Chen M, Shi J, Chang EB, Penaloza-MacMaster P, Tian B, Huang J. A Neutralizing Antibody-Conjugated Photothermal Nanoparticle Captures and Inactivates SARS-CoV-2. bioRxiv. 2020 Nov 30. View in: PubMed

  20. Lee M, Chang EB. Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues. Gastroenterology. 2021 01; 160(2):524-537. View in: PubMed

  21. Miyoshi J, Rao MC, Chang EB. Navigating the Human Gut Microbiome: Pathway to Success from Lessons Learned. Gastroenterology. 2020 12; 159(6):2019-2024. View in: PubMed

  22. Kwan JYY, Famiyeh P, Su J, Xu W, Kwan BYM, Jones JM, Chang E, Yip KW, Liu FF. Development and Validation of a Risk Model for Breast Cancer-Related Lymphedema. JAMA Netw Open. 2020 11 02; 3(11):e2024373. View in: PubMed

  23. Lopez CJ, Pritlove C, Jones JM, Alibhai SMH, Sabiston CM, Chang E, Santa Mina D. "This is my home-based exercise": exploring environmental influences on home-based exercise participation in oncology. Support Care Cancer. 2021 Jun; 29(6):3245-3255. View in: PubMed

  24. Brahmbhatt P, Sabiston CM, Lopez C, Chang E, Goodman J, Jones J, McCready D, Randall I, Rotstein S, Santa Mina D. Feasibility of Prehabilitation Prior to Breast Cancer Surgery: A Mixed-Methods Study. Front Oncol. 2020; 10:571091. View in: PubMed

  25. MacDonald AM, Chafranskaia A, Lopez CJ, Maganti M, Bernstein LJ, Chang E, Langelier DM, Obadia M, Edwards B, Oh P, Bender JL, Alibhai SM, Jones JM. CaRE @ Home: Pilot Study of an Online Multidimensional Cancer Rehabilitation and Exercise Program for Cancer Survivors. J Clin Med. 2020 Sep 25; 9(10). View in: PubMed

  26. Miyoshi J, Lee STM, Kennedy M, Puertolas M, Frith M, Koval JC, Miyoshi S, Antonopoulos DA, Leone V, Chang EB. Metagenomic Alterations in Gut Microbiota Precede and Predict Onset of Colitis in the IL10 Gene-Deficient Murine Model. Cell Mol Gastroenterol Hepatol. 2021; 11(2):491-502. View in: PubMed

  27. Nooromid M, Chen EB, Xiong L, Shapiro K, Jiang Q, Demsas F, Eskandari M, Priyadarshini M, Chang EB, Layden BT, Ho KJ. Microbe-Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury. J Am Heart Assoc. 2020 07 07; 9(13):e016235. View in: PubMed

  28. Watterson WJ, Tanyeri M, Watson AR, Cham CM, Shan Y, Chang EB, Eren AM, Tay S. Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes. Elife. 2020 06 17; 9. View in: PubMed

  29. Santa Mina D, Dolan LB, Lipton JH, Au D, Camacho Pérez E, Franzese A, Alibhai SMH, Jones JM, Chang E. Exercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial. J Clin Med. 2020 Jun 14; 9(6). View in: PubMed

  30. Janus SE, Chang E, Hoit BD. Authors' Response: The three faces of Takotsubo cardiomyopathy in a single patient. Echocardiography. 2020 07; 37(7):1136-1137. View in: PubMed

  31. Sidebottom AM, Chang EB. IBD Microbial Metabolome: The Good, Bad, and Unknown. Trends Endocrinol Metab. 2020 11; 31(11):807-809. View in: PubMed

  32. Dodiya HB, Frith M, Sidebottom A, Cao Y, Koval J, Chang E, Sisodia SS. Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice. Sci Rep. 2020 05 18; 10(1):8183. View in: PubMed

  33. Shi Y, Zheng W, Yang K, Harris KG, Ni K, Xue L, Lin W, Chang EB, Weichselbaum RR, Fu YX. Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling. J Exp Med. 2020 05 04; 217(5). View in: PubMed

  34. Chen EB, Shapiro KE, Wun K, Kuntz T, Theriault BR, Nooromid MJ, Leone VA, Harris KG, Jiang Q, Spedale M, Xiong L, Gilbert JA, Chang EB, Ho KJ. Microbial Colonization of Germ-Free Mice Restores Neointimal Hyperplasia Development After Arterial Injury. J Am Heart Assoc. 2020 03 03; 9(5):e013496. View in: PubMed

  35. Cason CA, Kuntz TM, Chen EB, Wun K, Nooromid MJ, Xiong L, Gottel NR, Harris KG, Morton TC, Avram MJ, Chang EB, Gilbert JA, Ho KJ. Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty. J Vasc Surg. 2020 04; 71(4):1378-1389.e3. View in: PubMed

  36. Willis KA, Gomes CK, Rao P, Micic D, Moran ER, Stephenson E, Puchowicz M, Al Abdallah Q, Mims TS, Gosain A, Yin D, Talati AJ, Chang EB, Han JC, Pierre JF. TGR5 signaling mitigates parenteral nutrition-associated liver disease. Am J Physiol Gastrointest Liver Physiol. 2020 02 01; 318(2):G322-G335. View in: PubMed

  37. Santa Mina D, Au D, Papadopoulos E, O'Neill M, Diniz C, Dolan L, Lipton J, Chang E, Jones JM. Aerobic capacity attainment and reasons for cardiopulmonary exercise test termination in people with cancer: a descriptive, retrospective analysis from a single laboratory. Support Care Cancer. 2020 Sep; 28(9):4285-4294. View in: PubMed

  38. Chang E, Kim Y. Vitamin D Ameliorates Fat Accumulation with AMPK/SIRT1 Activity in C2C12 Skeletal Muscle Cells. Nutrients. 2019 Nov 17; 11(11). View in: PubMed

  39. Frazier K, Chang EB. Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism. Trends Endocrinol Metab. 2020 01; 31(1):25-36. View in: PubMed

  40. Gaines S, van Praagh JB, Williamson AJ, Jacobson RA, Hyoju S, Zaborin A, Mao J, Koo HY, Alpert L, Bissonnette M, Weichselbaum R, Gilbert J, Chang E, Hyman N, Zaborina O, Shogan BD, Alverdy JC. Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery. Gastroenterology. 2020 03; 158(4):958-970.e2. View in: PubMed

  41. Martinez-Guryn K, Leone V, Chang EB. Regional Diversity of the Gastrointestinal Microbiome. Cell Host Microbe. 2019 09 11; 26(3):314-324. View in: PubMed

  42. Santa Mina D, Au D, Auger LE, Alibhai SMH, Matthew AG, Sabiston CM, Oh P, Ritvo PG, Chang EB, Jones JM. Development, implementation, and effects of a cancer center's exercise-oncology program. Cancer. 2019 10 01; 125(19):3437-3447. View in: PubMed

  43. Shan Y, Segre JA, Chang EB. Responsible stewardship for communicating microbiome research to the press and public. Nat Med. 2019 06; 25(6):872-874. View in: PubMed

  44. Pizarro TT, Stappenbeck TS, Rieder F, Rosen MJ, Colombel JF, Donowitz M, Towne J, Mazmanian SK, Faith JJ, Hodin RA, Garrett WS, Fichera A, Poritz LS, Cortes CJ, Shtraizent N, Honig G, Snapper SB, Hurtado-Lorenzo A, Salzman NH, Chang EB. Challenges in IBD Research: Preclinical Human IBD Mechanisms. Inflamm Bowel Dis. 2019 05 16; 25(Suppl 2):S5-S12. View in: PubMed

  45. Pierre JF, Li Y, Gomes CK, Rao P, Chang EB, Yin DP. Bile Diversion Improves Metabolic Phenotype Dependent on Farnesoid X Receptor (FXR). Obesity (Silver Spring). 2019 05; 27(5):803-812. View in: PubMed

  46. Zhang YG, Zhu X, Lu R, Messer JS, Xia Y, Chang EB, Sun J. Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy. Autophagy. 2019 11; 15(11):1935-1953. View in: PubMed

  47. Kim SY, Lee MS, Chang E, Jung S, Ko H, Lee E, Lee S, Kim CT, Kim IH, Kim Y. Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats. Nutrients. 2019 Mar 18; 11(3). View in: PubMed

  48. Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Zingarelli B, Fan H. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury. Crit Care. 2019 02 13; 23(1):44. View in: PubMed

  49. Schwartz MH, Wang H, Pan JN, Clark WC, Cui S, Eckwahl MJ, Pan DW, Parisien M, Owens SM, Cheng BL, Martinez K, Xu J, Chang EB, Pan T, Eren AM. Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis. Nat Commun. 2018 12 17; 9(1):5353. View in: PubMed

  50. Wun K, Theriault BR, Pierre JF, Chen EB, Leone VA, Harris KG, Xiong L, Jiang Q, Spedale M, Eskandari OM, Chang EB, Ho KJ. Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury. PLoS One. 2018; 13(12):e0208426. View in: PubMed

  51. Zhong X, Yu J, Frazier K, Weng X, Li Y, Cham CM, Dolan K, Zhu X, Hubert N, Tao Y, Lin F, Martinez-Guryn K, Huang Y, Wang T, Liu J, He C, Chang EB, Leone V. Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation. Cell Rep. 2018 11 13; 25(7):1816-1828.e4. View in: PubMed

  52. Harris KG, Chang EB. The intestinal microbiota in the pathogenesis of inflammatory bowel diseases: new insights into complex disease. Clin Sci (Lond). 2018 09 28; 132(18):2013-2028. View in: PubMed

  53. Mina DS, Langelier D, Adams SC, Alibhai SMH, Chasen M, Campbell KL, Oh P, Jones JM, Chang E. Exercise as part of routine cancer care. Lancet Oncol. 2018 09; 19(9):e433-e436. View in: PubMed

  54. Pierre JF, Hinterleitner R, Bouziat R, Hubert N, Leone V, Miyoshi J, Jabri B, Chang EB. Data on changes to mucosal inflammation and the intestinal microbiota following dietary micronutrients in genetically susceptible hosts. Data Brief. 2018 Oct; 20:387-393. View in: PubMed

  55. Chang EB, Martinez-Guryn K. Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption. Gut Microbes. 2019; 10(2):235-240. View in: PubMed

  56. Klurfeld DM, Davis CD, Karp RW, Allen-Vercoe E, Chang EB, Chassaing B, Fahey GC, Hamaker BR, Holscher HD, Lampe JW, Marette A, Martens E, O'Keefe SJ, Rose DJ, Saarela M, Schneeman BO, Slavin JL, Sonnenburg JL, Swanson KS, Wu GD, Lynch CJ. Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome. Am J Physiol Endocrinol Metab. 2018 12 01; 315(6):E1087-E1097. View in: PubMed

  57. Beck MW, Kathayat RS, Cham CM, Chang EB, Dickinson BC. Correction: Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues. Chem Sci. 2017 11 01; 8(11):7879. View in: PubMed

  58. Miyoshi J, Leone V, Nobutani K, Musch MW, Martinez-Guryn K, Wang Y, Miyoshi S, Bobe AM, Eren AM, Chang EB. Minimizing confounders and increasing data quality in murine models for studies of the gut microbiome. PeerJ. 2018; 6:e5166. View in: PubMed

  59. Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Busque L, Godley LA, Verdú EF, Barreiro LB, Jabri B. Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature. 2018 05; 557(7706):580-584. View in: PubMed

  60. Miyoshi J, Nobutani K, Musch MW, Ringus DL, Hubert NA, Yamamoto M, Kase Y, Nishiyama M, Chang EB. Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100). Evid Based Complement Alternat Med. 2018; 2018:7415975. View in: PubMed

  61. Martinez-Guryn K, Hubert N, Frazier K, Urlass S, Musch MW, Ojeda P, Pierre JF, Miyoshi J, Sontag TJ, Cham CM, Reardon CA, Leone V, Chang EB. Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids. Cell Host Microbe. 2018 04 11; 23(4):458-469.e5. View in: PubMed

  62. Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Fan H. Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis. Mol Ther. 2018 05 02; 26(5):1375-1384. View in: PubMed

  63. Beck MW, Kathayat RS, Cham CM, Chang EB, Dickinson BC. Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues. Chem Sci. 2017 Nov 01; 8(11):7588-7592. View in: PubMed

  64. Pierre JF, Hinterleitner R, Bouziat R, Hubert NA, Leone V, Miyoshi J, Jabri B, Chang EB. Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility. J Nutr Biochem. 2018 04; 54:95-104. View in: PubMed

  65. Cason CA, Dolan KT, Sharma G, Tao M, Kulkarni R, Helenowski IB, Doane BM, Avram MJ, McDermott MM, Chang EB, Ozaki CK, Ho KJ. Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes. J Vasc Surg. 2018 11; 68(5):1552-1562.e7. View in: PubMed

  66. Rentea RM, Guo Y, Zhu X, Musch MW, Chang EB, Gourlay DM, Liedel JL. Role of intestinal Hsp70 in barrier maintenance: contribution of milk to the induction of Hsp70.2. Pediatr Surg Int. 2018 Mar; 34(3):323-330. View in: PubMed

  67. Maruvada P, Leone V, Kaplan LM, Chang EB. The Human Microbiome and Obesity: Moving beyond Associations. Cell Host Microbe. 2017 Nov 08; 22(5):589-599. View in: PubMed

  68. Wang Y, Lin F, Zhu X, Leone VA, Dalal S, Tao Y, Messer JS, Chang EB. Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis. Am J Physiol Gastrointest Liver Physiol. 2018 02 01; 314(2):G164-G178. View in: PubMed

  69. Guo Y, Chang E, Bozkurt M, Park M, Liu D, Fu JB. Factors affecting hospital length of stay following pelvic exenteration surgery. J Surg Oncol. 2018 Mar; 117(3):529-534. View in: PubMed

  70. Wang CZ, Huang WH, Zhang CF, Wan JY, Wang Y, Yu C, Williams S, He TC, Du W, Musch MW, Chang EB, Yuan CS. Correction to: Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice. Clin Transl Oncol. 2018 03; 20(3):425. View in: PubMed

  71. Nobutani K, Miyoshi J, Musch MW, Nishiyama M, Watanabe J, Kaneko A, Yamamoto M, Yoshida M, Kono T, Jeong H, Chang EB. Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal. Pharmacol Res Perspect. 2017 10; 5(5). View in: PubMed

  72. Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease. Sci Rep. 2017 09 05; 7(1):10411. View in: PubMed

  73. Cho S, Tripathi A, Chlipala G, Green S, Lee H, Chang EB, Jeong H. Fructose diet alleviates acetaminophen-induced hepatotoxicity in mice. PLoS One. 2017; 12(8):e0182977. View in: PubMed

  74. Wang CZ, Huang WH, Zhang CF, Wan JY, Wang Y, Yu C, Williams S, He TC, Du W, Musch MW, Chang EB, Yuan CS. Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected]. Clin Transl Oncol. 2018 03; 20(3):302-312. View in: PubMed

  75. Raizada MK, Joe B, Bryan NS, Chang EB, Dewhirst FE, Borisy GG, Galis ZS, Henderson W, Jose PA, Ketchum CJ, Lampe JW, Pepine CJ, Pluznick JL, Raj D, Seals DR, Gioscia-Ryan RA, Tang WHW, Oh YS. Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions. Hypertension. 2017 Jul 31. View in: PubMed

  76. Miyoshi J, Bobe AM, Miyoshi S, Huang Y, Hubert N, Delmont TO, Eren AM, Leone V, Chang EB. Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring. Cell Rep. 2017 07 11; 20(2):491-504. View in: PubMed

  77. Chang EB, Rao MC. A new role for microbiota? Dulling the thrust of serotonin and 5-HT3 signaling cascade. Am J Physiol Gastrointest Liver Physiol. 2017 07 01; 313(1):G14-G15. View in: PubMed

  78. Guo Y, Li P, Gao L, Zhang J, Yang Z, Bledsoe G, Chang E, Chao L, Chao J. Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway. Aging Cell. 2017 08; 16(4):837-846. View in: PubMed

  79. Martinez KB, Leone V, Chang EB. Microbial metabolites in health and disease: Navigating the unknown in search of function. J Biol Chem. 2017 05 26; 292(21):8553-8559. View in: PubMed

  80. Chang E, Kim Y. Vitamin D Insufficiency Exacerbates Adipose Tissue Macrophage Infiltration and Decreases AMPK/SIRT1 Activity in Obese Rats. Nutrients. 2017 Mar 29; 9(4). View in: PubMed

  81. Touw K, Ringus DL, Hubert N, Wang Y, Leone VA, Nadimpalli A, Theriault BR, Huang YE, Tune JD, Herring PB, Farrugia G, Kashyap PC, Antonopoulos DA, Chang EB. Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models. Physiol Rep. 2017 Mar; 5(6). View in: PubMed

  82. Chang E, Nayak L, Jain MK. Krüppel-like factors in endothelial cell biology. Curr Opin Hematol. 2017 May; 24(3):224-229. View in: PubMed

  83. Huang Y, Dalal S, Antonopoulos D, Hubert N, Raffals LH, Dolan K, Weber C, Messer JS, Jabri B, Bendelac A, Eren AM, Rubin DT, Sogin M, Chang EB. Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. Inflamm Bowel Dis. 2017 Feb 13. View in: PubMed

  84. Huang Y, Dalal S, Antonopoulos D, Hubert N, Raffals LH, Dolan K, Weber C, Messer JS, Jabri B, Bendelac A, Eren AM, Rubin DT, Sogin M, Chang EB. Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. Inflamm Bowel Dis. 2017 03; 23(3):366-378. View in: PubMed

  85. Messer JS, Liechty ER, Vogel OA, Chang EB. Evolutionary and ecological forces that shape the bacterial communities of the human gut. Mucosal Immunol. 2017 05; 10(3):567-579. View in: PubMed

  86. Rodriguez-Palacios A, Corridoni D, Di Stefano G, Di Martino L, Antonopoulos DA, Chang E, Pizarro TT, Cominelli F. O-014 Bacterial Sensor NOD2 Deletion Causes Th2-Inflammatory Bowel Disease Improvement Without Inducing Acute Metatranscriptomic Dysbiosis in Mice. Inflamm Bowel Dis. 2017 Feb; 23 Suppl 1:S5. View in: PubMed

  87. Martinez KB, Leone V, Chang EB. Western diets, gut dysbiosis, and metabolic diseases: Are they linked? Gut Microbes. 2017 03 04; 8(2):130-142. View in: PubMed

  88. Vineis JH, Ringus DL, Morrison HG, Delmont TO, Dalal S, Raffals LH, Antonopoulos DA, Rubin DT, Eren AM, Chang EB, Sogin ML. Patient-Specific Bacteroides Genome Variants in Pouchitis. mBio. 2016 11 15; 7(6). View in: PubMed

  89. Corridoni D, Rodriguez-Palacios A, Di Stefano G, Di Martino L, Antonopoulos DA, Chang EB, Arseneau KO, Pizarro TT, Cominelli F. Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis. Mucosal Immunol. 2017 07; 10(4):971-982. View in: PubMed

  90. Martinez KB, Pierre JF, Chang EB. The Gut Microbiota: The Gateway to Improved Metabolism. Gastroenterol Clin North Am. 2016 12; 45(4):601-614. View in: PubMed

  91. Poroyko VA, Carreras A, Khalyfa A, Khalyfa AA, Leone V, Peris E, Almendros I, Gileles-Hillel A, Qiao Z, Hubert N, Farré R, Chang EB, Gozal D. Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice. Sci Rep. 2016 10 14; 6:35405. View in: PubMed

  92. Arvans D, Jung YC, Antonopoulos D, Koval J, Granja I, Bashir M, Karrar E, Roy-Chowdhury J, Musch M, Asplin J, Chang E, Hassan H. Oxalobacter formigenes-Derived Bioactive Factors Stimulate Oxalate Transport by Intestinal Epithelial Cells. J Am Soc Nephrol. 2017 Mar; 28(3):876-887. View in: PubMed

  93. Hasebe T, Matsukawa J, Ringus D, Miyoshi J, Hart J, Kaneko A, Yamamoto M, Kono T, Fujiya M, Kohgo Y, Wang CZ, Yuan CS, Bissonnette M, Musch MW, Chang EB. Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer. Phytother Res. 2017 Jan; 31(1):90-99. View in: PubMed

  94. Wan JY, Wang CZ, Zhang QH, Liu Z, Musch MW, Bissonnette M, Chang EB, Li P, Qi LW, Yuan CS. Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota. Biomed Chromatogr. 2017 Apr; 31(4). View in: PubMed

  95. Uchiyama K, Sakiyama T, Hasebe T, Musch MW, Miyoshi H, Nakagawa Y, He TC, Lichtenstein L, Naito Y, Itoh Y, Yoshikawa T, Jabri B, Stappenbeck T, Chang EB. Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development. Sci Rep. 2016 08 26; 6:32094. View in: PubMed

  96. Inaba Y, Ueno N, Numata M, Zhu X, Messer JS, Boone DL, Fujiya M, Kohgo Y, Musch MW, Chang EB. Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G634-G647. View in: PubMed

  97. Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease. Sci Rep. 2016 07 21; 6:30028. View in: PubMed

  98. Sato H, Zhang LS, Martinez K, Chang EB, Yang Q, Wang F, Howles PN, Hokari R, Miura S, Tso P. Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats. Gastroenterology. 2016 11; 151(5):923-932. View in: PubMed

  99. Raffals LE, Chang EB. Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel. Gut Liver. 2016 Jul 15; 10(4):502-8. View in: PubMed

  100. Miyoshi J, Chang EB. The gut microbiota and inflammatory bowel diseases. Transl Res. 2017 01; 179:38-48. View in: PubMed

  101. Dolan KT, Chang EB. Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases. Mol Nutr Food Res. 2017 01; 61(1). View in: PubMed

  102. Pierre JF, Martinez KB, Ye H, Nadimpalli A, Morton TC, Yang J, Wang Q, Patno N, Chang EB, Yin DP. Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice. Am J Physiol Gastrointest Liver Physiol. 2016 08 01; 311(2):G286-304. View in: PubMed

  103. Tao Y, Messer JS, Goss KH, Hart J, Bissonnette M, Chang EB. Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model. Carcinogenesis. 2016 07; 37(7):731-739. View in: PubMed

  104. Antonopoulos DA, Chang EB. Transplanting a Microbial Organ: the Good, the Bad, and the Unknown. mBio. 2016 05 03; 7(3). View in: PubMed

  105. Collins B, Hoffman J, Martinez K, Grace M, Lila MA, Cockrell C, Nadimpalli A, Chang E, Chuang CC, Zhong W, Mackert J, Shen W, Cooney P, Hopkins R, McIntosh M. A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice. J Nutr Biochem. 2016 05; 31:150-65. View in: PubMed

  106. Chang E, Abe JI. Kinase-SUMO networks in diabetes-mediated cardiovascular disease. Metabolism. 2016 May; 65(5):623-633. View in: PubMed

  107. Ward MA, Pierre JF, Leal RF, Huang Y, Shogan B, Dalal SR, Weber CR, Leone VA, Musch MW, An GC, Rao MC, Rubin DT, Raffals LE, Antonopoulos DA, Sogin ML, Hyman NH, Alverdy JC, Chang EB. Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility. Am J Physiol Gastrointest Liver Physiol. 2016 06 01; 310(11):G973-88. View in: PubMed

  108. Hasebe T, Ueno N, Musch MW, Nadimpalli A, Kaneko A, Kaifuchi N, Watanabe J, Yamamoto M, Kono T, Inaba Y, Fujiya M, Kohgo Y, Chang EB. Daikenchuto (TU-100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K. Pharmacol Res Perspect. 2016 02; 4(1):e00215. View in: PubMed

  109. Chang E, Kim Y. Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes. Nutrition. 2016 Jun; 32(6):702-8. View in: PubMed

  110. Wan JY, Wang CZ, Liu Z, Zhang QH, Musch MW, Bissonnette M, Chang EB, Li P, Qi LW, Yuan CS. Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15; 1015-1016:62-73. View in: PubMed

  111. Park SE, Park CY, Choi JM, Chang E, Rhee EJ, Lee WY, Oh KW, Park SW, Kang ES, Lee HC, Cha BS. Depot-Specific Changes in Fat Metabolism with Aging in a Type 2 Diabetic Animal Model. PLoS One. 2016; 11(2):e0148141. View in: PubMed

  112. Huang CK, Lee SO, Chang E, Pang H, Chang C. Androgen receptor (AR) in cardiovascular diseases. J Endocrinol. 2016 04; 229(1):R1-R16. View in: PubMed

  113. Kamdar K, Khakpour S, Chen J, Leone V, Brulc J, Mangatu T, Antonopoulos DA, Chang EB, Kahn SA, Kirschner BS, Young G, DePaolo RW. Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease. Cell Host Microbe. 2016 Jan 13; 19(1):21-31. View in: PubMed

  114. Willis AL, Calton JB, Carr TF, Chiu AG, Chang EH. Dead or alive: Deoxyribonuclease I sensitive bacteria and implications for the sinus microbiome. Am J Rhinol Allergy. 2016 Mar-Apr; 30(2):94-8. View in: PubMed

  115. Ho KJ, Xiong L, Hubert NA, Nadimpalli A, Wun K, Chang EB, Kibbe MR. Vancomycin treatment and butyrate supplementation modulate gut microbe composition and severity of neointimal hyperplasia after arterial injury. Physiol Rep. 2015 12; 3(12). View in: PubMed

  116. Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML, Chang EB, Gajewski TF. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 2015 Nov 27; 350(6264):1084-9. View in: PubMed

  117. Howe A, Ringus DL, Williams RJ, Choo ZN, Greenwald SM, Owens SM, Coleman ML, Meyer F, Chang EB. Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice. ISME J. 2016 May; 10(5):1217-27. View in: PubMed

  118. Hu S, Liu L, Chang EB, Wang JY, Raufman JP. Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells. Mol Cancer. 2015 Oct 13; 14:180. View in: PubMed

  119. Baldwin J, Collins B, Wolf PG, Martinez K, Shen W, Chuang CC, Zhong W, Cooney P, Cockrell C, Chang E, Gaskins HR, McIntosh MK. Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice. J Nutr Biochem. 2016 Jan; 27:123-35. View in: PubMed

  120. Seo S, Lee MS, Chang E, Shin Y, Oh S, Kim IH, Kim Y. Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats. Nutrients. 2015 Sep 22; 7(9):8152-69. View in: PubMed

  121. Huang CK, Luo J, Lai KP, Wang R, Pang H, Chang E, Yan C, Sparks J, Lee SO, Cho J, Chang C. Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1a and transforming growth factor-ß1 expression. Hypertension. 2015 Oct; 66(4):881-91. View in: PubMed

  122. Chang E, Kim L, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 07; 21(25):7754-63. View in: PubMed

  123. Chang EH, Zabner J. Precision Genomic Medicine in Cystic Fibrosis. Clin Transl Sci. 2015 Oct; 8(5):606-10. View in: PubMed

  124. Devkota S, Chang EB. Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases. Dig Dis. 2015; 33(3):351-6. View in: PubMed

  125. Chang E, Choi JM, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY. Adiponectin deletion impairs insulin signaling in insulin-sensitive but not insulin-resistant 3T3-L1 adipocytes. Life Sci. 2015 Jul 01; 132:93-100. View in: PubMed

  126. Lu L, Yu Y, Guo Y, Wang Y, Chang EB, Claud EC. Transcriptional modulation of intestinal innate defense/inflammation genes by preterm infant microbiota in a humanized gnotobiotic mouse model. PLoS One. 2015; 10(4):e0124504. View in: PubMed

  127. Messer J, Chang E. Intracellular HMGB1: defender of client proteins and cell fate. Oncotarget. 2015 Apr 20; 6(11):8432-3. View in: PubMed

  128. Leone V, Gibbons SM, Martinez K, Hutchison AL, Huang EY, Cham CM, Pierre JF, Heneghan AF, Nadimpalli A, Hubert N, Zale E, Wang Y, Huang Y, Theriault B, Dinner AR, Musch MW, Kudsk KA, Prendergast BJ, Gilbert JA, Chang EB. Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell Host Microbe. 2015 May 13; 17(5):681-9. View in: PubMed

  129. Kim M, Christley S, Khodarev NN, Fleming I, Huang Y, Chang E, Zaborina O, Alverdy JC. Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact. J Trauma Acute Care Surg. 2015 Apr; 78(4):823-9. View in: PubMed

  130. Cockrell RC, Christley S, Chang E, An G. Towards anatomic scale agent-based modeling with a massively parallel spatially explicit general-purpose model of enteric tissue (SEGMEnT_HPC). PLoS One. 2015; 10(3):e0122192. View in: PubMed

  131. Bellaguarda E, Chang EB. IBD and the gut microbiota--from bench to personalized medicine. Curr Gastroenterol Rep. 2015 Apr; 17(4):15. View in: PubMed

  132. Huang EY, Inoue T, Leone VA, Dalal S, Touw K, Wang Y, Musch MW, Theriault B, Higuchi K, Donovan S, Gilbert J, Chang EB. Using corticosteroids to reshape the gut microbiome: implications for inflammatory bowel diseases. Inflamm Bowel Dis. 2015 May; 21(5):963-72. View in: PubMed

  133. Chang E, Kim L, Choi JM, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park DI, Park CY. Ezetimibe stimulates intestinal glucagon-like peptide 1 secretion via the MEK/ERK pathway rather than dipeptidyl peptidase 4 inhibition. Metabolism. 2015 May; 64(5):633-41. View in: PubMed

  134. Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J. Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. J Clin Invest. 2015 Mar 02; 125(3):1299-310. View in: PubMed

  135. Zhu X, Messer JS, Wang Y, Lin F, Cham CM, Chang J, Billiar TR, Lotze MT, Boone DL, Chang EB. Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest. 2015 Mar 02; 125(3):1098-110. View in: PubMed

  136. Sun J, Chang EB. Exploring gut microbes in human health and disease: Pushing the envelope. Genes Dis. 2014 Dec; 1(2):132-139. View in: PubMed

  137. Chang EB, Guandalini S, Rao MC, Sellin JH, Semrad CE, Worman H. Michael Field, MD (1933-2014). Gastroenterology. 2014 Dec; 147(6):1191-2. View in: PubMed

  138. Chang EH, Tang XX, Shah VS, Launspach JL, Ernst SE, Hilkin B, Karp PH, Abou Alaiwa MH, Graham SM, Hornick DB, Welsh MJ, Stoltz DA, Zabner J. Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor. Int Forum Allergy Rhinol. 2015 Feb; 5(2):178-81. View in: PubMed

  139. Gao L, Li P, Zhang J, Hagiwara M, Shen B, Bledsoe G, Chang E, Chao L, Chao J. Novel role of kallistatin in vascular repair by promoting mobility, viability, and function of endothelial progenitor cells. J Am Heart Assoc. 2014 Sep 18; 3(5):e001194. View in: PubMed

  140. Leone VA, Cham CM, Chang EB. Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases? Curr Opin Immunol. 2014 Dec; 31:16-23. View in: PubMed

  141. Stefka AT, Feehley T, Tripathi P, Qiu J, McCoy K, Mazmanian SK, Tjota MY, Seo GY, Cao S, Theriault BR, Antonopoulos DA, Zhou L, Chang EB, Fu YX, Nagler CR. Commensal bacteria protect against food allergen sensitization. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13145-50. View in: PubMed

  142. Yang SJ, Choi JM, Chang E, Park SW, Park CY. Sirt1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation. PLoS One. 2014; 9(8):e105456. View in: PubMed

  143. Dalal SR, Chang EB. The microbial basis of inflammatory bowel diseases. J Clin Invest. 2014 Oct; 124(10):4190-6. View in: PubMed

  144. Wu S, Zhang YG, Lu R, Xia Y, Zhou D, Petrof EO, Claud EC, Chen D, Chang EB, Carmeliet G, Sun J. Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis. Gut. 2015 Jul; 64(7):1082-94. View in: PubMed

  145. Ma L, Kim J, Hatzenpichler R, Karymov MA, Hubert N, Hanan IM, Chang EB, Ismagilov RF. Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project's Most Wanted taxa. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9768-73. View in: PubMed

  146. Chang E, Choi JM, Kim WJ, Rhee EJ, Oh KW, Lee WY, Park SE, Park SW, Park CY. Restoration of adiponectin expression via the ERK pathway in TNFa-treated 3T3-L1 adipocytes. Mol Med Rep. 2014 Aug; 10(2):905-10. View in: PubMed

  147. Ueno N, Hasebe T, Kaneko A, Yamamoto M, Fujiya M, Kohgo Y, Kono T, Wang CZ, Yuan CS, Bissonnette M, Chang EB, Musch MW. TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independent effects involving Akt and NF-?B suppression. PLoS One. 2014; 9(5):e97456. View in: PubMed

  148. Fan H, Goodwin AJ, Chang E, Zingarelli B, Borg K, Guan S, Halushka PV, Cook JA. Endothelial progenitor cells and a stromal cell-derived factor-1a analogue synergistically improve survival in sepsis. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1509-19. View in: PubMed

  149. Huang CK, Pang H, Wang L, Niu Y, Luo J, Chang E, Sparks JD, Lee SO, Chang C. New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis. Hypertension. 2014 Jun; 63(6):1345-53. View in: PubMed

  150. Evans CC, LePard KJ, Kwak JW, Stancukas MC, Laskowski S, Dougherty J, Moulton L, Glawe A, Wang Y, Leone V, Antonopoulos DA, Smith D, Chang EB, Ciancio MJ. Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity. PLoS One. 2014; 9(3):e92193. View in: PubMed

  151. Elson CO, Chang EB, Lira SA. Lloyd F. Mayer, MD: a remembrance. Mucosal Immunol. 2014 Mar; 7(2):205-9. View in: PubMed

  152. Huse SM, Young VB, Morrison HG, Antonopoulos DA, Kwon J, Dalal S, Arrieta R, Hubert NA, Shen L, Vineis JH, Koval JC, Sogin ML, Chang EB, Raffals LE. Comparison of brush and biopsy sampling methods of the ileal pouch for assessment of mucosa-associated microbiota of human subjects. Microbiome. 2014 Feb 14; 2(1):5. View in: PubMed

  153. Shogan BD, Smith DP, Packman AI, Kelley ST, Landon EM, Bhangar S, Vora GJ, Jones RM, Keegan K, Stephens B, Ramos T, Kirkup BC, Levin H, Rosenthal M, Foxman B, Chang EB, Siegel J, Cobey S, An G, Alverdy JC, Olsiewski PJ, Martin MO, Marrs R, Hernandez M, Christley S, Morowitz M, Weber S, Gilbert J. The Hospital Microbiome Project: Meeting report for the 2nd Hospital Microbiome Project, Chicago, USA, January 15(th), 2013. Stand Genomic Sci. 2013 Jul 30; 8(3):571-9. View in: PubMed

  154. Young VB, Raffals LH, Huse SM, Vital M, Dai D, Schloss PD, Brulc JM, Antonopoulos DA, Arrieta RL, Kwon JH, Reddy KG, Hubert NA, Grim SL, Vineis JH, Dalal S, Morrison HG, Eren AM, Meyer F, Schmidt TM, Tiedje JM, Chang EB, Sogin ML. Multiphasic analysis of the temporal development of the distal gut microbiota in patients following ileal pouch anal anastomosis. Microbiome. 2013 Mar 04; 1(1):9. View in: PubMed

  155. Vital M, Penton CR, Wang Q, Young VB, Antonopoulos DA, Sogin ML, Morrison HG, Raffals L, Chang EB, Huffnagle GB, Schmidt TM, Cole JR, Tiedje JM. A gene-targeted approach to investigate the intestinal butyrate-producing bacterial community. Microbiome. 2013 Mar 04; 1(1):8. View in: PubMed

  156. Claud EC, Keegan KP, Brulc JM, Lu L, Bartels D, Glass E, Chang EB, Meyer F, Antonopoulos DA. Bacterial community structure and functional contributions to emergence of health or necrotizing enterocolitis in preterm infants. Microbiome. 2013 Jul 10; 1(1):20. View in: PubMed

  157. Alverdy J, Gilbert J, DeFazio JR, Sadowsky MJ, Chang EB, Morowitz MJ, Teitelbaum DH. Proceedings of the 2013 A.S.P.E.N. Research workshop: the interface between nutrition and the gut microbiome: implications and applications for human health [corrected]. JPEN J Parenter Enteral Nutr. 2014 Feb; 38(2):167-78. View in: PubMed

  158. Huang H, Nace GW, McDonald KA, Tai S, Klune JR, Rosborough BR, Ding Q, Loughran P, Zhu X, Beer-Stolz D, Chang EB, Billiar T, Tsung A. Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection. Hepatology. 2014 May; 59(5):1984-1997. View in: PubMed

  159. Kang R, Zhang Q, Hou W, Yan Z, Chen R, Bonaroti J, Bansal P, Billiar TR, Tsung A, Wang Q, Bartlett DL, Whitcomb DC, Chang EB, Zhu X, Wang H, Lu B, Tracey KJ, Cao L, Fan XG, Lotze MT, Zeh HJ, Tang D. Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice. Gastroenterology. 2014 Apr; 146(4):1097-107. View in: PubMed

  160. Chang EH. New insights into the pathogenesis of cystic fibrosis sinusitis. Int Forum Allergy Rhinol. 2014 Feb; 4(2):132-7. View in: PubMed

  161. Devkota S, Chang EB. Nutrition, microbiomes, and intestinal inflammation. Curr Opin Gastroenterol. 2013 Nov; 29(6):603-7. View in: PubMed

  162. Dennis KL, Wang Y, Blatner NR, Wang S, Saadalla A, Trudeau E, Roers A, Weaver CT, Lee JJ, Gilbert JA, Chang EB, Khazaie K. Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells. Cancer Res. 2013 Oct 01; 73(19):5905-13. View in: PubMed

  163. Huang EY, Devkota S, Moscoso D, Chang EB, Leone VA. The role of diet in triggering human inflammatory disorders in the modern age. Microbes Infect. 2013 Nov; 15(12):765-74. View in: PubMed

  164. Bhattacharyya S, Xue L, Devkota S, Chang E, Morris S, Tobacman JK. Carrageenan-induced colonic inflammation is reduced in Bcl10 null mice and increased in IL-10-deficient mice. Mediators Inflamm. 2013; 2013:397642. View in: PubMed

  165. Stoltz DA, Rokhlina T, Ernst SE, Pezzulo AA, Ostedgaard LS, Karp PH, Samuel MS, Reznikov LR, Rector MV, Gansemer ND, Bouzek DC, Abou Alaiwa MH, Hoegger MJ, Ludwig PS, Taft PJ, Wallen TJ, Wohlford-Lenane C, McMenimen JD, Chen JH, Bogan KL, Adam RJ, Hornick EE, Nelson GA, Hoffman EA, Chang EH, Zabner J, McCray PB, Prather RS, Meyerholz DK, Welsh MJ. Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. J Clin Invest. 2013 Jun; 123(6):2685-93. View in: PubMed

  166. Huang EY, Leone VA, Devkota S, Wang Y, Brady MJ, Chang EB. Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue. JPEN J Parenter Enteral Nutr. 2013 Nov; 37(6):746-54. View in: PubMed

  167. Potash AE, Wallen TJ, Karp PH, Ernst S, Moninger TO, Gansemer ND, Stoltz DA, Zabner J, Chang EH. Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model. Mol Ther. 2013 May; 21(5):947-53. View in: PubMed

  168. Leone V, Chang EB, Devkota S. Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases. J Gastroenterol. 2013 Mar; 48(3):315-21. View in: PubMed

  169. Zhang Z, Du GJ, Wang CZ, Wen XD, Calway T, Li Z, He TC, Du W, Bissonnette M, Musch MW, Chang EB, Yuan CS. Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions. Int J Mol Sci. 2013 Jan 31; 14(2):2980-95. View in: PubMed

  170. Heo KS, Chang E, Le NT, Cushman H, Yeh ET, Fujiwara K, Abe J. De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis. Circ Res. 2013 Mar 15; 112(6):911-23. View in: PubMed

  171. Devkota S, Chang EB. Diet-induced expansion of pathobionts in experimental colitis: implications for tailored therapies. Gut Microbes. 2013 Mar-Apr; 4(2):172-4. View in: PubMed

  172. Musch MW, Wang Y, Claud EC, Chang EB. Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota. Dig Dis Sci. 2013 Mar; 58(3):668-77. View in: PubMed

  173. Urayama S, Chang EB. Mechanisms and treatment of diarrhea in inflammatory bowel diseases. Inflamm Bowel Dis. 1997; 3(2):114-31. View in: PubMed

  174. Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe J. A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation. 2013 Jan 29; 127(4):486-99. View in: PubMed

  175. Heo KS, Chang E, Takei Y, Le NT, Woo CH, Sullivan MA, Morrell C, Fujiwara K, Abe J. Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):321-9. View in: PubMed

  176. Meyer F, Trimble WL, Chang EB, Handley KM. Functional predictions from inference and observation in sequence-based inflammatory bowel disease research. Genome Biol. 2012; 13(9):169. View in: PubMed

  177. Upadhyay V, Poroyko V, Kim TJ, Devkota S, Fu S, Liu D, Tumanov AV, Koroleva EP, Deng L, Nagler C, Chang EB, Tang H, Fu YX. Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nat Immunol. 2012 Oct; 13(10):947-53. View in: PubMed

  178. Hansen JJ, Huang Y, Peterson DA, Goeser L, Fan TJ, Chang EB, Sartor RB. The colitis-associated transcriptional profile of commensal Bacteroides thetaiotaomicron enhances adaptive immune responses to a bacterial antigen. PLoS One. 2012; 7(8):e42645. View in: PubMed

  179. Vieira Potter VJ, Strissel KJ, Xie C, Chang E, Bennett G, Defuria J, Obin MS, Greenberg AS. Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity. Endocrinology. 2012 Sep; 153(9):4266-77. View in: PubMed

  180. Devkota S, Wang Y, Musch MW, Leone V, Fehlner-Peach H, Nadimpalli A, Antonopoulos DA, Jabri B, Chang EB. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature. 2012 Jul 05; 487(7405):104-8. View in: PubMed

  181. Chang EH, Pezzulo AA, Meyerholz DK, Potash AE, Wallen TJ, Reznikov LR, Sieren JC, Karp PH, Ernst S, Moninger TO, Gansemer ND, McCray PB, Stoltz DA, Welsh MJ, Zabner J. Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis. Laryngoscope. 2012 Sep; 122(9):1898-905. View in: PubMed

  182. Chang EY, Zhang J, Sullivan S, Newman R, Singh I. N-acetylcysteine prevents preterm birth by attenuating the LPS-induced expression of contractile associated proteins in an animal model. J Matern Fetal Neonatal Med. 2012 Nov; 25(11):2395-400. View in: PubMed

  183. Schneider JA, Vadivelu S, Liao C, Kandukuri SR, Trikamji BV, Chang E, Antonopoulos D, Prasad S, Lakshmi V. Increased Likelihood of Bacterial Pathogens in the Coronal Sulcus and Urethra of Uncircumcised Men in a Diverse Group of HIV Infected and Uninfected Patients in India. J Glob Infect Dis. 2012 Jan; 4(1):6-9. View in: PubMed

  184. Afrazi A, Sodhi CP, Good M, Jia H, Siggers R, Yazji I, Ma C, Neal MD, Prindle T, Grant ZS, Branca MF, Ozolek J, Chang EB, Hackam DJ. Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. J Immunol. 2012 May 01; 188(9):4543-57. View in: PubMed

  185. Wang CZ, Du GJ, Zhang Z, Wen XD, Calway T, Zhen Z, Musch MW, Bissonnette M, Chang EB, Yuan CS. Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer. Int J Oncol. 2012 Jun; 40(6):1970-6. View in: PubMed

  186. Harrell L, Wang Y, Antonopoulos D, Young V, Lichtenstein L, Huang Y, Hanauer S, Chang E. Standard colonic lavage alters the natural state of mucosal-associated microbiota in the human colon. PLoS One. 2012; 7(2):e32545. View in: PubMed

  187. Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H, Mizukami Y, Chang EB, Kohgo Y. Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection. Int J Colorectal Dis. 2012 Aug; 27(8):1039-46. View in: PubMed

  188. Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J. p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. Circ Res. 2012 Feb 17; 110(4):536-50. View in: PubMed

  189. Wang CZ, Kim KE, Du GJ, Qi LW, Wen XD, Li P, Bauer BA, Bissonnette MB, Musch MW, Chang EB, Yuan CS. Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma. Am J Chin Med. 2011; 39(6):1161-71. View in: PubMed

  190. Dougherty U, Mustafi R, Wang Y, Musch MW, Wang CZ, Konda VJ, Kulkarni A, Hart J, Dawson G, Kim KE, Yuan CS, Chang EB, Bissonnette M. American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR. BMC Complement Altern Med. 2011 Nov 09; 11:111. View in: PubMed

  191. Young VB, Kahn SA, Schmidt TM, Chang EB. Studying the Enteric Microbiome in Inflammatory Bowel Diseases: Getting through the Growing Pains and Moving Forward. Front Microbiol. 2011; 2:144. View in: PubMed

  192. Lacruz RS, Smith CE, Moffatt P, Chang EH, Bromage TG, Bringas P, Nanci A, Baniwal SK, Zabner J, Welsh MJ, Kurtz I, Paine ML. Requirements for ion and solute transport, and pH regulation during enamel maturation. J Cell Physiol. 2012 Apr; 227(4):1776-85. View in: PubMed

  193. Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King MR, Berk BC, Fujiwara K, Woo CH, Abe J. PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. J Cell Biol. 2011 May 30; 193(5):867-84. View in: PubMed

  194. Pekow JR, Dougherty U, Mustafi R, Zhu H, Kocherginsky M, Rubin DT, Hanauer SB, Hart J, Chang EB, Fichera A, Joseph LJ, Bissonnette M. miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes. Inflamm Bowel Dis. 2012 Jan; 18(1):94-100. View in: PubMed

  195. Chang EH, Lacruz RS, Bromage TG, Bringas P, Welsh MJ, Zabner J, Paine ML. Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model. Cells Tissues Organs. 2011; 194(2-4):249-54. View in: PubMed

  196. Sack C, Smoker M, Chamkasem N, Thompson R, Satterfield G, Masse C, Mercer G, Neuhaus B, Cassias I, Chang E, Lin Y, Macmahon S, Wong J, Zhang K, Smith RE. Collaborative validation of the QuEChERS procedure for the determination of pesticides in food by LC-MS/MS. J Agric Food Chem. 2011 Jun 22; 59(12):6383-411. View in: PubMed

  197. Iwashita Y, Sakiyama T, Musch MW, Ropeleski MJ, Tsubouchi H, Chang EB. Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response. Am J Physiol Gastrointest Liver Physiol. 2011 Jul; 301(1):G181-7. View in: PubMed

  198. Perfield JW, Lee Y, Shulman GI, Samuel VT, Jurczak MJ, Chang E, Xie C, Tsichlis PN, Obin MS, Greenberg AS. Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. Diabetes. 2011 Apr; 60(4):1168-76. View in: PubMed

  199. Hu S, Dong TS, Dalal SR, Wu F, Bissonnette M, Kwon JH, Chang EB. The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer. PLoS One. 2011 Jan 20; 6(1):e16221. View in: PubMed

  200. Leung FW, Aljebreen AM, Brocchi E, Chang EB, Liao WC, Mizukami T, Schapiro M, Triantafyllou K. Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening. World J Gastrointest Endosc. 2010 Mar 16; 2(3):81-9. View in: PubMed

  201. Chang E, Heo KS, Woo CH, Lee H, Le NT, Thomas TN, Fujiwara K, Abe J. MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation. Blood. 2011 Feb 24; 117(8):2527-37. View in: PubMed

  202. Wang Y, Devkota S, Musch MW, Jabri B, Nagler C, Antonopoulos DA, Chervonsky A, Chang EB. Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon. PLoS One. 2010 Oct 22; 5(10):e13607. View in: PubMed

  203. Lee JW, Cho YK, Ryan M, Kim H, Lee SW, Chang E, Joo KJ, Kim JT, Kim BS, Sung KC. Serum uric Acid as a predictor for the development of nonalcoholic Fatty liver disease in apparently healthy subjects: a 5-year retrospective cohort study. Gut Liver. 2010 Sep; 4(3):378-83. View in: PubMed

  204. Wang Y, Antonopoulos DA, Zhu X, Harrell L, Hanan I, Alverdy JC, Meyer F, Musch MW, Young VB, Chang EB. Laser capture microdissection and metagenomic analysis of intact mucosa-associated microbial communities of human colon. Appl Microbiol Biotechnol. 2010 Dec; 88(6):1333-42. View in: PubMed

  205. Hu S, Wang Y, Lichtenstein L, Tao Y, Musch MW, Jabri B, Antonopoulos D, Claud EC, Chang EB. Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins. Am J Physiol Gastrointest Liver Physiol. 2010 Dec; 299(6):G1266-75. View in: PubMed

  206. Woo CH, Le NT, Shishido T, Chang E, Lee H, Heo KS, Mickelsen DM, Lu Y, McClain C, Spangenberg T, Yan C, Molina CA, Yang J, Patterson C, Abe J. Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor. FASEB J. 2010 Dec; 24(12):4917-28. View in: PubMed

  207. Fujiya M, Inaba Y, Musch MW, Hu S, Kohgo Y, Chang EB. Cytokine regulation of OCTN2 expression and activity in small and large intestine. Inflamm Bowel Dis. 2011 Apr; 17(4):907-16. View in: PubMed

  208. Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, Hanfland RA, Wohlford-Lenane C, Dohrn CL, Bartlett JA, Nelson GA, Chang EH, Taft PJ, Ludwig PS, Estin M, Hornick EE, Launspach JL, Samuel M, Rokhlina T, Karp PH, Ostedgaard LS, Uc A, Starner TD, Horswill AR, Brogden KA, Prather RS, Richter SS, Shilyansky J, McCray PB, Zabner J, Welsh MJ. Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med. 2010 Apr 28; 2(29):29ra31. View in: PubMed

  209. Chang EH, Lee JH, Zabner J. Tryptase does not alter transepithelial conductance or paracellular permeability in human airway epithelial cells. Am J Rhinol Allergy. 2010 Mar-Apr; 24(2):126-8. View in: PubMed

  210. Hu S, Claud EC, Musch MW, Chang EB. Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha. Am J Physiol Gastrointest Liver Physiol. 2010 Apr; 298(4):G481-92. View in: PubMed

  211. Yeruva S, Farkas K, Hubricht J, Rode K, Riederer B, Bachmann O, Cinar A, Rakonczay Z, Molnár T, Nagy F, Wedemeyer J, Manns M, Raddatz D, Musch MW, Chang EB, Hegyi P, Seidler U. Preserved Na(+)/H(+) exchanger isoform 3 expression and localization, but decreased NHE3 function indicate regulatory sodium transport defect in ulcerative colitis. Inflamm Bowel Dis. 2010 Jul; 16(7):1149-61. View in: PubMed

  212. Musch MW, Arvans DL, Wang Y, Nakagawa Y, Solomaha E, Chang EB. Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1. Am J Physiol Gastrointest Liver Physiol. 2010 Feb; 298(2):G203-11. View in: PubMed

  213. Valuckaite V, Zaborina O, Long J, Hauer-Jensen M, Wang J, Holbrook C, Zaborin A, Drabik K, Katdare M, Mauceri H, Weichselbaum R, Firestone MA, Lee KY, Chang EB, Matthews J, Alverdy JC. Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1041-52. View in: PubMed

  214. Jenkins DD, Chang E, Singh I. Neuroprotective interventions: is it too late? J Child Neurol. 2009 Sep; 24(9):1212-9. View in: PubMed

  215. Musch MW, Arvans DL, Paris H, Chang EB. Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3. J Pharmacol Exp Ther. 2009 Sep; 330(3):818-25. View in: PubMed

  216. Chang E, Donkin SS, Teegarden D. Parathyroid hormone suppresses insulin signaling in adipocytes. Mol Cell Endocrinol. 2009 Aug 13; 307(1-2):77-82. View in: PubMed

  217. Petrof EO, Claud EC, Sun J, Abramova T, Guo Y, Waypa TS, He SM, Nakagawa Y, Chang EB. Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function. Inflamm Bowel Dis. 2009 Oct; 15(10):1537-47. View in: PubMed

  218. Wang Y, Hoenig JD, Malin KJ, Qamar S, Petrof EO, Sun J, Antonopoulos DA, Chang EB, Claud EC. 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis. ISME J. 2009 Aug; 3(8):944-54. View in: PubMed

  219. Musch MW, Li YC, Chang EB. Angiotensin II directly regulates intestinal epithelial NHE3 in Caco2BBE cells. BMC Physiol. 2009 Apr 01; 9:5. View in: PubMed

  220. Bourdeau RW, Malito E, Chenal A, Bishop BL, Musch MW, Villereal ML, Chang EB, Mosser EM, Rest RF, Tang WJ. Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis. J Biol Chem. 2009 May 22; 284(21):14645-56. View in: PubMed

  221. Hu S, Zhu X, Triggs JR, Tao Y, Wang Y, Lichtenstein L, Bissonnette M, Musch MW, Chang EB. Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis. Am J Physiol Gastrointest Liver Physiol. 2009 May; 296(5):G1003-11. View in: PubMed

  222. Sakiyama T, Musch MW, Ropeleski MJ, Tsubouchi H, Chang EB. Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells. Gastroenterology. 2009 Mar; 136(3):924-32. View in: PubMed

  223. Siddiqui SM, Chang E, Li J, Burlage C, Zou M, Buhman KK, Koser S, Donkin SS, Teegarden D. Dietary intervention with vitamin D, calcium, and whey protein reduced fat mass and increased lean mass in rats. Nutr Res. 2008 Nov; 28(11):783-90. View in: PubMed

  224. Musch MW, Arvans DL, Wu GD, Chang EB. Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G202-10. View in: PubMed

  225. Tao Y, Hart J, Lichtenstein L, Joseph LJ, Ciancio MJ, Hu S, Chang EB, Bissonnette M. Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer. Carcinogenesis. 2009 Jan; 30(1):175-82. View in: PubMed

  226. Li J, Byrne ME, Chang E, Jiang Y, Donkin SS, Buhman KK, Burgess JR, Teegarden D. 1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes. J Steroid Biochem Mol Biol. 2008 Nov; 112(1-3):122-6. View in: PubMed

  227. Ciancio MJ, Chang EB. Do heat shock proteins play any role in gut inflammation? Inflamm Bowel Dis. 2008 Oct; 14 Suppl 2:S102-3. View in: PubMed

  228. Musch MW, Lucioni A, Chang EB. Aldosterone regulation of intestinal Na absorption involves SGK-mediated changes in NHE3 and Na+ pump activity. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 295(5):G909-19. View in: PubMed

  229. Sellin JH, Chang EB. Therapy Insight: gastrointestinal complications of diabetes--pathophysiology and management. Nat Clin Pract Gastroenterol Hepatol. 2008 Mar; 5(3):162-71. View in: PubMed

  230. Petrof EO, Musch MW, Ciancio M, Sun J, Hobert ME, Claud EC, Gewirtz A, Chang EB. Flagellin is required for salmonella-induced expression of heat shock protein Hsp25 in intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G808-18. View in: PubMed

  231. Ko R, Mazur JE, Pastis NJ, Chang E, Sahn SA, Boylan AM. Common problems in critically ill obstetric patients, with an emphasis on pharmacotherapy. Am J Med Sci. 2008 Jan; 335(1):65-70. View in: PubMed

  232. Alverdy JC, Chang EB. The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away. J Leukoc Biol. 2008 Mar; 83(3):461-6. View in: PubMed

  233. Hu S, Ciancio MJ, Lahav M, Fujiya M, Lichtenstein L, Anant S, Musch MW, Chang EB. Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation. Gastroenterology. 2007 Dec; 133(6):1893-904. View in: PubMed

  234. Fujiya M, Musch MW, Nakagawa Y, Hu S, Alverdy J, Kohgo Y, Schneewind O, Jabri B, Chang EB. The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter. Cell Host Microbe. 2007 Jun 14; 1(4):299-308. View in: PubMed

  235. Cash BD, Chang E, Talley NJ, Wald A. Fresh perspectives in chronic constipation and other functional bowel disorders. Rev Gastroenterol Disord. 2007; 7(3):116-33. View in: PubMed

  236. Chang EY, Morris CD, Seltman AK, O'Rourke RW, Chan BK, Hunter JG, Jobe BA. The effect of antireflux surgery on esophageal carcinogenesis in patients with barrett esophagus: a systematic review. Ann Surg. 2007 Jul; 246(1):11-21. View in: PubMed

  237. Zaborina O, Lepine F, Xiao G, Valuckaite V, Chen Y, Li T, Ciancio M, Zaborin A, Petrof EO, Petroff E, Turner JR, Rahme LG, Chang E, Alverdy JC. Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathog. 2007 Mar; 3(3):e35. View in: PubMed

  238. Musch MW, Arvans DL, Walsh-Reitz MM, Uchiyama K, Fukuda M, Chang EB. Synaptotagmin I binds intestinal epithelial NHE3 and mediates cAMP- and Ca2+-induced endocytosis by recruitment of AP2 and clathrin. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1549-58. View in: PubMed

  239. Chang E, Ni J, Yin Y, Lin CC, Chang P, James NS, Chemler SR, Yeh S. Alpha-vitamin E derivative, RRR-alpha-tocopheryloxybutyric acid inhibits the proliferation of prostate cancer cells. Asian J Androl. 2007 Jan; 9(1):31-9. View in: PubMed

  240. Carlson RM, Vavricka SR, Eloranta JJ, Musch MW, Arvans DL, Kles KA, Walsh-Reitz MM, Kullak-Ublick GA, Chang EB. fMLP induces Hsp27 expression, attenuates NF-kappaB activation, and confers intestinal epithelial cell protection. Am J Physiol Gastrointest Liver Physiol. 2007 Apr; 292(4):G1070-8. View in: PubMed

  241. O'Rourke RW, Seltman AK, Chang EY, Reavis KM, Diggs BS, Hunter JG, Jobe BA. A model for gastric banding in the treatment of morbid obesity: the effect of chronic partial gastric outlet obstruction on esophageal physiology. Ann Surg. 2006 Nov; 244(5):723-33. View in: PubMed

  242. Lahav M, Chang E. Immunologic basis for diarrhea. Curr Opin Gastroenterol. 2002 Nov; 18(6):691-5. View in: PubMed

  243. Patel NJ, Zaborina O, Wu L, Wang Y, Wolfgeher DJ, Valuckaite V, Ciancio MJ, Kohler JE, Shevchenko O, Colgan SP, Chang EB, Turner JR, Alverdy JC. Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G134-42. View in: PubMed

  244. Wu L, Kohler JE, Zaborina O, Akash G, Musch MW, Chang EB, Alverdy JC. Chronic acid water feeding protects mice against lethal gut-derived sepsis due to Pseudomonas aeruginosa. Curr Issues Intest Microbiol. 2006 Mar; 7(1):19-28. View in: PubMed

  245. Phanvijhitsiri K, Musch MW, Ropeleski MJ, Chang EB. Heat induction of heat shock protein 25 requires cellular glutamine in intestinal epithelial cells. Am J Physiol Cell Physiol. 2006 Aug; 291(2):C290-9. View in: PubMed

  246. Kles KA, Chang EB. Short-chain fatty acids impact on intestinal adaptation, inflammation, carcinoma, and failure. Gastroenterology. 2006 Feb; 130(2 Suppl 1):S100-5. View in: PubMed

  247. Gopal DV, Chang EY, Kim CY, Sandone C, Pfau PR, Frick TJ, Hunter JG, Kahrilas PJ, Jobe BA. EUS characteristics of Nissen fundoplication: normal appearance and mechanisms of failure. Gastrointest Endosc. 2006 Jan; 63(1):35-44. View in: PubMed

  248. Vavricka SR, Musch MW, Fujiya M, Kles K, Chang L, Eloranta JJ, Kullak-Ublick GA, Drabik K, Merlin D, Chang EB. Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine. Pflugers Arch. 2006 Apr; 452(1):71-80. View in: PubMed

  249. Tao Y, Drabik KA, Waypa TS, Musch MW, Alverdy JC, Schneewind O, Chang EB, Petrof EO. Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol. 2006 Apr; 290(4):C1018-30. View in: PubMed

  250. Musch MW, Walsh-Reitz MM, Chang EB. Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption. Am J Physiol Gastrointest Liver Physiol. 2006 Feb; 290(2):G222-31. View in: PubMed

  251. Harrell L, Chang EB. This month in gastroenterology. Gastroenterology. 2005 Oct; 129(4):1143-5. View in: PubMed

  252. Wu LR, Zaborina O, Zaborin A, Chang EB, Musch M, Holbrook C, Turner JR, Alverdy JC. Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa. Surg Infect (Larchmt). 2005; 6(2):185-95. View in: PubMed

  253. Wu L, Estrada O, Zaborina O, Bains M, Shen L, Kohler JE, Patel N, Musch MW, Chang EB, Fu YX, Jacobs MA, Nishimura MI, Hancock RE, Turner JR, Alverdy JC. Recognition of host immune activation by Pseudomonas aeruginosa. Science. 2005 Jul 29; 309(5735):774-7. View in: PubMed

  254. Ropeleski MJ, Riehm J, Baer KA, Musch MW, Chang EB. Anti-apoptotic effects of L-glutamine-mediated transcriptional modulation of the heat shock protein 72 during heat shock. Gastroenterology. 2005 Jul; 129(1):170-84. View in: PubMed

  255. Walsh-Reitz MM, Huang EF, Musch MW, Chang EB, Martin TE, Kartha S, Toback FG. AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins. Am J Physiol Gastrointest Liver Physiol. 2005 Jul; 289(1):G163-71. View in: PubMed

  256. Chang E, Chalikonda S, Friedl J, Xu H, Phan GQ, Marincola FM, Alexander HR, Bartlett DL. Targeting vaccinia to solid tumors with local hyperthermia. Hum Gene Ther. 2005 Apr; 16(4):435-44. View in: PubMed

  257. Reavis KM, Chang EY, Hunter JG, Jobe BA. Utilization of the delay phenomenon improves blood flow and reduces collagen deposition in esophagogastric anastomoses. Ann Surg. 2005 May; 241(5):736-45; discussion 745-7. View in: PubMed

  258. Sun J, Hobert ME, Duan Y, Rao AS, He TC, Chang EB, Madara JL. Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Jul; 289(1):G129-37. View in: PubMed

  259. Kles KA, Vavricka SR, Turner JR, Musch MW, Hanauer SB, Chang EB. Comparative analysis of the in vitro prosecretory effects of balsalazide, sulfasalazine, olsalazine, and mesalamine in rabbit distal ileum. Inflamm Bowel Dis. 2005 Mar; 11(3):253-7. View in: PubMed

  260. Petrof EO, Ciancio MJ, Chang EB. Role and regulation of intestinal epithelial heat shock proteins in health and disease. Chin J Dig Dis. 2004; 5(2):45-50. View in: PubMed

  261. Shiue H, Musch MW, Wang Y, Chang EB, Turner JR. Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation. J Biol Chem. 2005 Jan 14; 280(2):1688-95. View in: PubMed

  262. Arvans DL, Vavricka SR, Ren H, Musch MW, Kang L, Rocha FG, Lucioni A, Turner JR, Alverdy J, Chang EB. Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72. Am J Physiol Gastrointest Liver Physiol. 2005 Apr; 288(4):G696-704. View in: PubMed

  263. Petrof EO, Kojima K, Ropeleski MJ, Musch MW, Tao Y, De Simone C, Chang EB. Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition. Gastroenterology. 2004 Nov; 127(5):1474-87. View in: PubMed

  264. Vavricka SR, Musch MW, Chang JE, Nakagawa Y, Phanvijhitsiri K, Waypa TS, Merlin D, Schneewind O, Chang EB. hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. Gastroenterology. 2004 Nov; 127(5):1401-9. View in: PubMed

  265. Zhao H, Shiue H, Palkon S, Wang Y, Cullinan P, Burkhardt JK, Musch MW, Chang EB, Turner JR. Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9485-90. View in: PubMed

  266. Musch MW, Petrof EO, Kojima K, Ren H, McKay DM, Chang EB. Bacterial superantigen-treated intestinal epithelial cells upregulate heat shock proteins 25 and 72 and are resistant to oxidant cytotoxicity. Infect Immun. 2004 Jun; 72(6):3187-94. View in: PubMed

  267. Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F. SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8090-5. View in: PubMed

  268. Wu L, Zaborina O, Zaborin A, Chang EB, Musch M, Holbrook C, Shapiro J, Turner JR, Wu G, Lee KY, Alverdy JC. High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosa. Gastroenterology. 2004 Feb; 126(2):488-98. View in: PubMed

  269. Musch MW, Kapil A, Chang EB. Heat shock protein 72 binds and protects dihydrofolate reductase against oxidative injury. Biochem Biophys Res Commun. 2004 Jan 02; 313(1):185-92. View in: PubMed

  270. Kojima K, Musch MW, Ropeleski MJ, Boone DL, Ma A, Chang EB. Escherichia coli LPS induces heat shock protein 25 in intestinal epithelial cells through MAP kinase activation. Am J Physiol Gastrointest Liver Physiol. 2004 Apr; 286(4):G645-52. View in: PubMed

  271. Ohtsu H, Itokawa H, Xiao Z, Su CY, Shih CC, Chiang T, Chang E, Lee Y, Chiu SY, Chang C, Lee KH. Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids. Bioorg Med Chem. 2003 Nov 17; 11(23):5083-90. View in: PubMed

  272. Wu L, Holbrook C, Zaborina O, Ploplys E, Rocha F, Pelham D, Chang E, Musch M, Alverdy J. Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System. Ann Surg. 2003 Nov; 238(5):754-64. View in: PubMed

  273. Toback FG, Walsh-Reitz MM, Musch MW, Chang EB, Del Valle J, Ren H, Huang E, Martin TE. Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic. Am J Physiol Gastrointest Liver Physiol. 2003 Aug; 285(2):G344-53. View in: PubMed

  274. Kojima K, Musch MW, Ren H, Boone DL, Hendrickson BA, Ma A, Chang EB. Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells. Gastroenterology. 2003 May; 124(5):1395-407. View in: PubMed

  275. Ropeleski MJ, Tang J, Walsh-Reitz MM, Musch MW, Chang EB. Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress. Gastroenterology. 2003 May; 124(5):1358-68. View in: PubMed

  276. Inui S, Lee YF, Chang E, Shyr CR, Chang C. Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes. J Dermatol Sci. 2003 Feb; 31(1):65-71. View in: PubMed

  277. Wischmeyer PE, Riehm J, Singleton KD, Ren H, Musch MW, Kahana M, Chang EB. Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. Nutrition. 2003 Jan; 19(1):1-6. View in: PubMed

  278. Liu TS, Musch MW, Sugi K, Walsh-Reitz MM, Ropeleski MJ, Hendrickson BA, Pothoulakis C, Lamont JT, Chang EB. Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C1073-82. View in: PubMed

  279. Musch MW, Clarke LL, Mamah D, Gawenis LR, Zhang Z, Ellsworth W, Shalowitz D, Mittal N, Efthimiou P, Alnadjim Z, Hurst SD, Chang EB, Barrett TA. T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase. J Clin Invest. 2002 Dec; 110(11):1739-47. View in: PubMed

  280. Ohtsu H, Xiao Z, Ishida J, Nagai M, Wang HK, Itokawa H, Su CY, Shih C, Chiang T, Chang E, Lee Y, Tsai MY, Chang C, Lee KH. Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. J Med Chem. 2002 Nov 07; 45(23):5037-42. View in: PubMed

  281. Musch MW, Bookstein C, Rocha F, Lucioni A, Ren H, Daniel J, Xie Y, McSwine RL, Rao MC, Alverdy J, Chang EB. Region-specific adaptation of apical Na/H exchangers after extensive proximal small bowel resection. Am J Physiol Gastrointest Liver Physiol. 2002 Oct; 283(4):G975-85. View in: PubMed

  282. Lucioni A, Womack C, Musch MW, Rocha FL, Bookstein C, Chang EB. Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function. Am J Physiol Gastrointest Liver Physiol. 2002 Jul; 283(1):G51-6. View in: PubMed

  283. Zhang Y, Ni J, Messing EM, Chang E, Yang CR, Yeh S. Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7408-13. View in: PubMed

  284. Wischmeyer PE, Kahana M, Wolfson R, Ren H, Musch MM, Chang EB. Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia. Shock. 2001 Nov; 16(5):398-402. View in: PubMed

  285. Ren H, Musch MW, Kojima K, Boone D, Ma A, Chang EB. Short-chain fatty acids induce intestinal epithelial heat shock protein 25 expression in rats and IEC 18 cells. Gastroenterology. 2001 Sep; 121(3):631-9. View in: PubMed

  286. Musch MW, Kaplan B, Chang EB. Role of increased basal expression of heat shock protein 72 in colonic epithelial c2BBE adenocarcinoma cells. Cell Growth Differ. 2001 Aug; 12(8):419-26. View in: PubMed

  287. Rocha F, Laughlin R, Musch MW, Hendrickson BA, Chang EB, Alverdy J. Surgical stress shifts the intestinal Escherichia coli population to that of a more adherent phenotype: role in barrier regulation. Surgery. 2001 Jul; 130(1):65-73. View in: PubMed

  288. Wischmeyer PE, Kahana M, Wolfson R, Ren H, Musch MM, Chang EB. Glutamine induces heat shock protein and protects against endotoxin shock in the rat. J Appl Physiol (1985). 2001 Jun; 90(6):2403-10. View in: PubMed

  289. Sugi K, Musch MW, Field M, Chang EB. Inhibition of Na+,K+-ATPase by interferon gamma down-regulates intestinal epithelial transport and barrier function. Gastroenterology. 2001 May; 120(6):1393-403. View in: PubMed

  290. Rocha F, Musch MW, Lishanskiy L, Bookstein C, Sugi K, Xie Y, Chang EB. IFN-gamma downregulates expression of Na(+)/H(+) exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells. Am J Physiol Cell Physiol. 2001 May; 280(5):C1224-32. View in: PubMed

  291. Musch MW, Bookstein C, Xie Y, Sellin JH, Chang EB. SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells. Am J Physiol Gastrointest Liver Physiol. 2001 Apr; 280(4):G687-93. View in: PubMed

  292. Sugi K, Musch MW, Di A, Nelson DJ, Chang EB. Oxidants potentiate Ca(2+)- and cAMP-stimulated Cl(-) secretion in intestinal epithelial T84 cells. Gastroenterology. 2001 Jan; 120(1):89-98. View in: PubMed

  293. Alverdy J, Holbrook C, Rocha F, Seiden L, Wu RL, Musch M, Chang E, Ohman D, Suh S. Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa. Ann Surg. 2000 Oct; 232(4):480-9. View in: PubMed

  294. Laughlin RS, Musch MW, Hollbrook CJ, Rocha FM, Chang EB, Alverdy JC. The key role of Pseudomonas aeruginosa PA-I lectin on experimental gut-derived sepsis. Ann Surg. 2000 Jul; 232(1):133-42. View in: PubMed

  295. Bookstein C, Musch MW, Xie Y, Rao MC, Chang EB. Regulation of intestinal epithelial brush border Na(+)/H(+) exchanger isoforms, NHE2 and NHE3, in C2bbe cells. J Membr Biol. 1999 Sep 01; 171(1):87-95. View in: PubMed

  296. Musch MW, Sugi K, Straus D, Chang EB. Heat-shock protein 72 protects against oxidant-induced injury of barrier function of human colonic epithelial Caco2/bbe cells. Gastroenterology. 1999 Jul; 117(1):115-22. View in: PubMed

  297. Bhartur SG, Ballarin LJ, Musch MW, Bookstein C, Chang EB, Rao MC. A unique Na+/H+ exchanger, analogous to NHE1, in the chicken embryonic fibroblast. Am J Physiol. 1999 03; 276(3):R838-46. View in: PubMed

  298. Park K, Olschowka JA, Richardson LA, Bookstein C, Chang EB, Melvin JE. Expression of multiple Na+/H+ exchanger isoforms in rat parotid acinar and ductal cells. Am J Physiol. 1999 02; 276(2):G470-8. View in: PubMed

  299. Urayama S, Musch MW, Retsky J, Madonna MB, Straus D, Chang EB. Dexamethasone protection of rat intestinal epithelial cells against oxidant injury is mediated by induction of heat shock protein 72. J Clin Invest. 1998 Nov 15; 102(10):1860-5. View in: PubMed

  300. McSwine RL, Musch MW, Bookstein C, Xie Y, Rao M, Chang EB. Regulation of apical membrane Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cell line C2/bbe. Am J Physiol. 1998 09; 275(3):C693-701. View in: PubMed

  301. Musch MW, Hayden D, Sugi K, Straus D, Chang EB. Cell-specific induction of hsp72-mediated protection by glutamine against oxidant injury in IEC18 cells. Proc Assoc Am Physicians. 1998 Mar-Apr; 110(2):136-9. View in: PubMed

  302. Cho JH, Musch MW, Bookstein CM, McSwine RL, Rabenau K, Chang EB. Aldosterone stimulates intestinal Na+ absorption in rats by increasing NHE3 expression of the proximal colon. Am J Physiol. 1998 03; 274(3):C586-94. View in: PubMed

  303. Bookstein C, Musch MW, Dudeja PK, McSwine RL, Xie Y, Brasitus TA, Rao MC, Chang EB. Inverse relationship between membrane lipid fluidity and activity of Na+/H+ exchangers, NHE1 and NHE3, in transfected fibroblasts. J Membr Biol. 1997 Dec 01; 160(3):183-92. View in: PubMed

  304. Bhartur SG, Bookstein C, Musch MW, Boxer R, Chang EB, Rao MC. An avian sodium-hydrogen exchanger. Comp Biochem Physiol A Physiol. 1997 Nov; 118(3):883-9. View in: PubMed

  305. Bookstein C, Xie Y, Rabenau K, Musch MW, McSwine RL, Rao MC, Chang EB. Tissue distribution of Na+/H+ exchanger isoforms NHE2 and NHE4 in rat intestine and kidney. Am J Physiol. 1997 11; 273(5):C1496-505. View in: PubMed

  306. Burress GC, Musch MW, Jurivich DA, Welk J, Chang EB. Effects of mesalamine on the hsp72 stress response in rat IEC-18 intestinal epithelial cells. Gastroenterology. 1997 Nov; 113(5):1474-9. View in: PubMed

  307. Wischmeyer PE, Musch MW, Madonna MB, Thisted R, Chang EB. Glutamine protects intestinal epithelial cells: role of inducible HSP70. Am J Physiol. 1997 Apr; 272(4 Pt 1):G879-84. View in: PubMed

  308. Coupaye-Gerard B, Bookstein C, Duncan P, Chen XY, Smith PR, Musch M, Ernst SA, Chang EB, Kleyman TR. Biosynthesis and cell surface delivery of the NHE1 isoform of Na+/H+ exchanger in A6 cells. Am J Physiol. 1996 Nov; 271(5 Pt 1):C1639-45. View in: PubMed

  309. Bookstein C, Musch MW, DePaoli A, Xie Y, Rabenau K, Villereal M, Rao MC, Chang EB. Characterization of the rat Na+/H+ exchanger isoform NHE4 and localization in rat hippocampus. Am J Physiol. 1996 Nov; 271(5 Pt 1):C1629-38. View in: PubMed

  310. Chang EB. Intestinal water and electrolyte absorption and secretion. Transplant Proc. 1996 Oct; 28(5):2679-82. View in: PubMed

  311. Bizal GL, Howard RL, Bookstein C, Rao MC, Chang EB, Soleimani M. Glycosylation of the Na+/H+ exchanger isoform NHE-3 is species specific. J Lab Clin Med. 1996 Sep; 128(3):304-12. View in: PubMed

  312. Musch MW, Ciancio MJ, Sarge K, Chang EB. Induction of heat shock protein 70 protects intestinal epithelial IEC-18 cells from oxidant and thermal injury. Am J Physiol. 1996 Feb; 270(2 Pt 1):C429-36. View in: PubMed

  313. Soleimani M, Singh G, Bookstein C, Rao MC, Chang EB, Dominguez JH. Inhibition of glycosylation decreases Na+/H+ exchange activity, blocks NHE-3 transport to the membrane, and increases NHE-3 mRNA expression in LLC-PK1 cells. J Lab Clin Med. 1996 Jun; 127(6):565-73. View in: PubMed

  314. Wilson KT, Vaandrager AB, De Vente J, Musch MW, De Jonge HR, Chang EB. Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport. Am J Physiol. 1996 Mar; 270(3 Pt 1):C832-40. View in: PubMed

  315. LaRusso NF, Phillips SF, Bloomer JR, Boland CR, Chang EB, DiMagno EP, Giannella RA, Gores GJ, Malagelada JR, Miller LJ, Rakela J, Szurszewski JH, Binder HJ, Clain JE, LaMont JT, Link AM. Passing the torch: a look back at our editorship. Gastroenterology. 1996 May; 110(5):1336-8. View in: PubMed

  316. Pamukcu R, Spiegel AM, Chang EB. Biochemical and immunochemical localization of GTP-binding proteins in the rat ileal enterocyte. J Lab Clin Med. 1993 May; 121(5):689-96. View in: PubMed

  317. Tamai H, Kachur JF, Grisham MB, Musch MW, Chang EB, Gaginella TS. Effect of the thiol-oxidizing agent diamide on NH2Cl-induced rat colonic electrolyte secretion. Am J Physiol. 1993 Jul; 265(1 Pt 1):C166-70. View in: PubMed

  318. Wilson KT, Xie Y, Musch MW, Chang EB. Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon. J Pharmacol Exp Ther. 1993 Jul; 266(1):224-30. View in: PubMed

  319. Bookstein C, DePaoli AM, Xie Y, Niu P, Musch MW, Rao MC, Chang EB. Na+/H+ exchangers, NHE-1 and NHE-3, of rat intestine. Expression and localization. J Clin Invest. 1994 Jan; 93(1):106-13. View in: PubMed

  320. Soleimani M, Bookstein C, McAteer JA, Hattabaugh YJ, Bizal GL, Musch MW, Villereal M, Rao MC, Howard RL, Chang EB. Effect of high osmolality on Na+/H+ exchange in renal proximal tubule cells. J Biol Chem. 1994 Jun 03; 269(22):15613-8. View in: PubMed

  321. Toskulkao C, Bhartur S, Musch MW, Chang EB, Rao MC. Phorbol dibutyrate-specific protein phosphorylation in brush border membranes of chicken enterocytes. J Cell Physiol. 1994 May; 159(2):347-55. View in: PubMed

  322. Burant CF, Flink S, DePaoli AM, Chen J, Lee WS, Hediger MA, Buse JB, Chang EB. Small intestine hexose transport in experimental diabetes. Increased transporter mRNA and protein expression in enterocytes. J Clin Invest. 1994 Feb; 93(2):578-85. View in: PubMed

  323. McSwine RL, Babnigg G, Musch MW, Chang EB, Villereal ML. Expression and phosphorylation of NHE1 in wild-type and transformed human and rodent fibroblasts. J Cell Physiol. 1994 Nov; 161(2):351-7. View in: PubMed

  324. Bookstein C, Musch MW, DePaoli A, Xie Y, Villereal M, Rao MC, Chang EB. A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity. J Biol Chem. 1994 Nov 25; 269(47):29704-9. View in: PubMed

  325. Cho JH, Musch MW, DePaoli AM, Bookstein CM, Xie Y, Burant CF, Rao MC, Chang EB. Glucocorticoids regulate Na+/H+ exchange expression and activity in region- and tissue-specific manner. Am J Physiol. 1994 Sep; 267(3 Pt 1):C796-803. View in: PubMed

  326. Soleimani M, Bookstein C, Bizal GL, Musch MW, Hattabaugh YJ, Rao MC, Chang EB. Localization of the Na+/H+ exchanger isoform NHE-3 in rabbit and canine kidney. Biochim Biophys Acta. 1994 Oct 12; 1195(1):89-95. View in: PubMed

  327. Soleimani M, Bookstein C, Singh G, Rao MC, Chang EB, Bastani B. Differential regulation of Na+/H+ exchange and H(+)-ATPase by pH and HCO3- in kidney proximal tubules. J Membr Biol. 1995 Apr; 144(3):209-16. View in: PubMed

  328. Shallat S, Schmidt L, Reaka A, Rao D, Chang EB, Rao MC, Ramaswamy K, Layden TJ. NHE-1 isoform of the Na+/H+ antiport is expressed in the rat and rabbit esophagus. Gastroenterology. 1995 Nov; 109(5):1421-8. View in: PubMed

  329. Chang EB, Brown DR, Field M, Miller RJ. An antiabsorptive basis for precipitated withdrawal diarrhea in morphine-dependent rats. J Pharmacol Exp Ther. 1984 Feb; 228(2):364-9. View in: PubMed

  330. Field M, Chang EB. Pancreatic cholera: is the diarrhea due to VIP? N Engl J Med. 1983 Dec 15; 309(24):1513-5. View in: PubMed

  331. Chang EB, Field M, Miller RJ. Enterocyte alpha 2-adrenergic receptors: yohimbine and p-aminoclonidine binding relative to ion transport. Am J Physiol. 1983 Jan; 244(1):G76-82. View in: PubMed

  332. Chang EB, Field M, Miller RJ. alpha 2-Adrenergic receptor regulation of ion transport in rabbit ileum. Am J Physiol. 1982 Mar; 242(3):G237-42. View in: PubMed

  333. Fedorak RN, Field M, Chang EB. Treatment of diabetic diarrhea with clonidine. Ann Intern Med. 1985 Feb; 102(2):197-9. View in: PubMed

  334. Ahn J, Chang EB, Field M. Phorbol ester inhibition of Na-H exchange in rabbit proximal colon. Am J Physiol. 1985 Nov; 249(5 Pt 1):C527-30. View in: PubMed

  335. Chang EB, Wang NS, Rao MC. Phorbol ester stimulation of active anion secretion in intestine. Am J Physiol. 1985 Sep; 249(3 Pt 1):C356-61. View in: PubMed

  336. Hirose R, Chang EB. Effects of serotonin on Na+-H+ exchange and intracellular calcium in isolated chicken enterocytes. Am J Physiol. 1988 Jun; 254(6 Pt 1):G891-7. View in: PubMed

  337. Carroll KM, Wong TT, Drabik DL, Chang EB. Differentiation of rat small intestinal epithelial cells by extracellular matrix. Am J Physiol. 1988 Mar; 254(3 Pt 1):G355-60. View in: PubMed

  338. Wood RJ, Carroll KM, Chang EB, Rosenberg IH. Effect of glucose on calcium transport in rat duodenum. Prog Clin Biol Res. 1988; 252:347-51. View in: PubMed

  339. Carroll KM, Wood RJ, Chang EB, Rosenberg IH. Glucose enhancement of transcellular calcium transport in the intestine. Am J Physiol. 1988 Sep; 255(3 Pt 1):G339-45. View in: PubMed

  340. Semrad CE, Chang EB. Calcium-mediated cyclic AMP inhibition of Na-H exchange in small intestine. Am J Physiol. 1987 Mar; 252(3 Pt 1):C315-22. View in: PubMed

  341. Chang EB, Bergenstal RM, Field M. Diarrhea in streptozocin-treated rats. Loss of adrenergic regulation of intestinal fluid and electrolyte transport. J Clin Invest. 1985 May; 75(5):1666-70. View in: PubMed

  342. Fedorak RN, Chang EB, Madara JL, Field M. Intestinal adaptation to diabetes. Altered Na-dependent nutrient absorption in streptozocin-treated chronically diabetic rats. J Clin Invest. 1987 Jun; 79(6):1571-8. View in: PubMed

  343. Roberts WG, Fedorak RN, Chang EB. In vitro effects of the long-acting somatostatin analogue SMS 201-995 on electrolyte transport by the rabbit ileum. Gastroenterology. 1988 Jun; 94(6):1343-50. View in: PubMed

  344. Chang EB, Fedorak RN, Field M. Experimental diabetic diarrhea in rats. Intestinal mucosal denervation hypersensitivity and treatment with clonidine. Gastroenterology. 1986 Sep; 91(3):564-9. View in: PubMed

  345. Pamukcu R, Hanauer SB, Chang EB. Effect of disodium azodisalicylate on electrolyte transport in rabbit ileum and colon in vitro. Comparison with sulfasalazine and 5-aminosalicylic acid. Gastroenterology. 1988 Oct; 95(4):975-81. View in: PubMed

  346. Chang EB. Salmonella bacterial adherence and penetration of mucosal cells: inducing role of the epithelium. Gastroenterology. 1989 Oct; 97(4):1055-6. View in: PubMed

  347. Field M, Rao MC, Chang EB. Intestinal electrolyte transport and diarrheal disease (2) N Engl J Med. 1989 Sep 28; 321(13):879-83. View in: PubMed

  348. Field M, Rao MC, Chang EB. Intestinal electrolyte transport and diarrheal disease (1). N Engl J Med. 1989 Sep 21; 321(12):800-6. View in: PubMed

  349. Chang EB. Transforming growth factors and intestinal epithelia: more questions than answers. Gastroenterology. 1989 Dec; 97(6):1587-8. View in: PubMed

  350. Fedorak RN, Kotake A, Douglas F, Chang EB. Inhibition of cholera-toxin-stimulated intestinal secretion by CGS 9343B in rats: a specific calmodulin inhibitor. J Pediatr Gastroenterol Nutr. 1989 Feb; 8(2):252-8. View in: PubMed

  351. Chang EB, Brown DR, Wang NS, Field M. Secretagogue-induced changes in membrane calcium permeability in chicken and chinchilla ileal mucosa. Selective inhibition by loperamide. J Clin Invest. 1986 Jul; 78(1):281-7. View in: PubMed

  352. Miller RJ, Brown DR, Chang EB, Friel DD. The pharmacological modification of secretory responses. Ciba Found Symp. 1985; 112:155-74. View in: PubMed

  353. Barrett TA, Chang EB. What's all the FLAP about? A new 5-lipoxygenase-binding protein identified! Gastroenterology. 1990 Oct; 99(4):1185-6. View in: PubMed

  354. Chang EB. Protein kinase C unleashed. Gastroenterology. 1990 Apr; 98(4):1091-2. View in: PubMed

  355. Chang EB. Acid secretion by parietal cells: relative roles for [Ca2+]i and protein kinase C. Gastroenterology. 1990 Jan; 98(1):244-5. View in: PubMed

  356. Chang EB. Posttranslational processing of ras proteins. Gastroenterology. 1990 Jul; 99(1):276-7. View in: PubMed

  357. Semrad CE, Cragoe EJ, Chang EB. Inhibition of Na/H exchange in avian intestine by atrial natriuretic factor. J Clin Invest. 1990 Aug; 86(2):585-91. View in: PubMed

  358. Musch MW, Nahkla AM, Chang EB. Phorbol ester-stimulated secretion in chicken ileum: role of arachidonic acid metabolism. Gastroenterology. 1990 Aug; 99(2):393-400. View in: PubMed

  359. Hoffman LR, Chang EB. Determinants of regional sucrase-isomaltase expression in adult rat small intestine. J Biol Chem. 1991 Nov 15; 266(32):21815-20. View in: PubMed

  360. Tamai H, Gaginella TS, Kachur JF, Musch MW, Chang EB. Ca-mediated stimulation of Cl secretion by reactive oxygen metabolites in human colonic T84 cells. J Clin Invest. 1992 Jan; 89(1):301-7. View in: PubMed

  361. Chang EB, Bookstein C, Vaandrager A, DeJonge HR, Buse J, Musch MW. Cystic fibrosis transmembrane regulator mRNA expression relative to ion-nutrient transport in spontaneously differentiating human intestinal CaCo-2 epithelial cells. J Lab Clin Med. 1991 Oct; 118(4):377-81. View in: PubMed

  362. Barrett TA, Musch MW, Chang EB. Chemotactic peptide effects on intestinal electrolyte transport. Am J Physiol. 1990 Dec; 259(6 Pt 1):G947-54. View in: PubMed

  363. Chang EB, Musch MW. Calcium mediated neurohumoral inhibition of chicken enterocyte Na influx: role of phosphatidylinositol metabolites. Life Sci. 1990; 46(26):1913-21. View in: PubMed

  364. Chang EB, Musch MW, Mayer L. Interleukins 1 and 3 stimulate anion secretion in chicken intestine. Gastroenterology. 1990 Jun; 98(6):1518-24. View in: PubMed

  365. Chang EB, Musch MW, Drabik-Arvans D, Rao MC. Phorbol ester inhibition of chicken intestinal brush-border sodium-proton exchange. Am J Physiol. 1991 Jun; 260(6 Pt 1):C1264-72. View in: PubMed

  366. Hoffman LR, Yen S, Chang EB. Regional alterations in intestinal sucrase expression in streptozocin-treated chronically diabetic rats. Dig Dis Sci. 1992 Jul; 37(7):1078-83. View in: PubMed

  367. Hoffman LR, Chang EB. Altered regulation of regional sucrase-isomaltase expression in diabetic rat intestine. Am J Physiol. 1992 Jun; 262(6 Pt 1):G983-9. View in: PubMed

  368. Ciancio MJ, Chang EB. Epithelial secretory response to inflammation. Ann N Y Acad Sci. 1992; 664:210-21. View in: PubMed

  369. Barrett TA, Gajewski TF, Danielpour D, Chang EB, Beagley KW, Bluestone JA. Differential function of intestinal intraepithelial lymphocyte subsets. J Immunol. 1992 Aug 15; 149(4):1124-30. View in: PubMed

  370. Ciancio MJ, Vitiritti L, Dhar A, Chang EB. Endotoxin-induced alterations in rat colonic water and electrolyte transport. Gastroenterology. 1992 Nov; 103(5):1437-43. View in: PubMed

  371. Musch MW, Bookstein C, Arvans DL, Cragoe EJ, Rao MC, Chang EB. Characterization of chicken intestinal brush border membrane Na/H exchange. Comp Biochem Physiol Comp Physiol. 1992 Nov; 103(3):439-44. View in: PubMed

  372. Musch MW, Drabik-Arvans D, Rao MC, Chang EB. Bethanechol inhibition of chicken intestinal brush border Na/H exchange: role of protein kinase C and other calcium-dependent processes. J Cell Physiol. 1992 Aug; 152(2):362-71. View in: PubMed
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