Ralph R. Weichselbaum, MD

University of Illinois
Chicago IL
MD - Medicine
1971

University of Wisconsin
Madison WI
BS - Liberal Arts
1967

Nanoparticle-Mediated Toll-Like Receptor Activation and Dual Immune Checkpoint Downregulation for Potent Cancer Immunotherapy.
Nanoparticle-Mediated Toll-Like Receptor Activation and Dual Immune Checkpoint Downregulation for Potent Cancer Immunotherapy. ACS Nano. 2025 Mar 11; 19(9):8852-8866.
PMID: 40009747

N6-methyladenosine reader YTHDF2 in cell state transition and antitumor immunity.
N6-methyladenosine reader YTHDF2 in cell state transition and antitumor immunity. RNA. 2025 Feb 19; 31(3):395-401.
PMID: 39719324

Metal-organic layer delivers 3-bromopyruvate to mitochondria for metabolic regulation and cancer radio-immunotherapy.
Metal-organic layer delivers 3-bromopyruvate to mitochondria for metabolic regulation and cancer radio-immunotherapy. Chem Sci. 2025 Feb 17.
PMID: 39991561

N6-methyladenosine reader YTHDF2 in cell state transition and antitumor immunity.
N6-methyladenosine reader YTHDF2 in cell state transition and antitumor immunity. RNA. 2024 Dec 24.
PMID: 39719324

Ionizing radiation improves skin bacterial dysbiosis in cutaneous T-cell lymphoma.
Ionizing radiation improves skin bacterial dysbiosis in cutaneous T-cell lymphoma. Front Immunol. 2024; 15:1520214.
PMID: 39776918

Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7th immunorad conference.
Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7th immunorad conference. Oncoimmunology. 2025 Dec; 14(1):2432726.
PMID: 39696783

YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production.
YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production. J Clin Invest. 2024 Dec 02; 134(23).
PMID: 39325547

Nanoscale Mixed-Ligand Metal-Organic Framework for X-ray Stimulated Cancer Therapy.
Nanoscale Mixed-Ligand Metal-Organic Framework for X-ray Stimulated Cancer Therapy. J Am Chem Soc. 2024 Dec 04; 146(48):33149-33158.
PMID: 39565960

Bifunctional Metal-Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio-Immunotherapy.
Bifunctional Metal-Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio-Immunotherapy. Angew Chem Int Ed Engl. 2025 Jan 27; 64(5):e202417027.
PMID: 39375150

Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment.
Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment. Angew Chem Int Ed Engl. 2024 Nov 11; 63(46):e202412844.
PMID: 39146242