Jill De Jong, MD PhD

  • Associate Professor of Pediatrics
    Committee on Cancer Biology
    Committee on Development, Regeneration, and Stem Cell Biology
  • Clinical Interests: Anemias, Autoimmune Blood Diseases, Benign Hematology, Bleeding Disorders, CAR TCell Therapy for Pediatric Cancers, Coagulation Disorders, Hematopoietic Malignancies, Hemoglobinopathies, Immunodeficiency, Pediatric Hematology, Pediatric Stem Cell Transplant, Sickle Cell Disease
  • Research and Scholarly Interests: Anemias, Aplastic Anemias, Bleeding disorders, Bone Marrow Failure syndromes, Cancer Genetic Risk, Clotting disorders, Hematopoietic Malignancy, Hemoglobinopathies, ITP, Neutropenias, Pediatric Hematology, Sickle Cell Disease, Thalassemia, Thrombocytopenias
  • Websites: Research Network Profile
  • Contact: jdejong@uchicago.edu
  • Graduate Programs: Cancer Biology, Development, Regeneration & Stem Cell Biology, UChicago Biosciences

Dr. de Jong treats children with all types of cancer and blood diseases. She is the Director of Pediatric Hematology and has specialized expertise in bone marrow failure, leukemia, autoimmune blood diseases (such as autoimmune hemolytic anemia, autoimmune neutropenia, immune thrombocytopenia purpura and Evans syndrome), hemoglobinopathies (such as thalassemia and sickle cell disease), and bleeding and clotting disorders.



Her research focuses on hematopoietic stem cells and genetic risks for hematologic malignancy. She is also studying the genetic causes of aplastic anemia. She is co-director of the Pediatric Cancer Genetic Risk clinic and the director of the Pediatric Bone Marrow Failure clinic.

Dana Farber Cancer Institute and Boston Children's Hospital
Boston, MA
Fellowship - Pediatric Hematology-Oncology
2005

Boston Children's Hospital
Boston, MA
Residency - Pediatrics
2002

University of Wisconsin
Madison, WI
MD - Medicine
1999

University of Wisconsin
Madison, WI
PhD - Cancer Biology
1997

University of Chicago
Chicago, IL
AB - Biology
1990

Sequential tumor molecular profiling identifies likely germline variants.
Sequential tumor molecular profiling identifies likely germline variants. Genet Med. 2024 Mar; 26(3):101037.
PMID: 38054407

Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes.
Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. Sci Rep. 2023 05 13; 13(1):7777.
PMID: 37179373

A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors.
A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors. Immunogenetics. 2023 02; 75(1):53-69.
PMID: 35869336

Hemorrhagic Shock after Neonatal Circumcision: Severe Congenital Factor XIII Deficiency.
Hemorrhagic Shock after Neonatal Circumcision: Severe Congenital Factor XIII Deficiency. Case Rep Pediatr. 2021; 2021:5550199.
PMID: 34007504

Synthetic CRISPR/Cas9 reagents facilitate genome editing and homology directed repair.
Synthetic CRISPR/Cas9 reagents facilitate genome editing and homology directed repair. Nucleic Acids Res. 2020 04 17; 48(7):e38.
PMID: 32064511

Splicing up hematopoietic development.
Splicing up hematopoietic development. Blood. 2019 02 21; 133(8):770-771.
PMID: 30792220

The side population enriches for leukemia-propagating cell activity and Wnt pathway expression in zebrafish acute lymphoblastic leukemia.
The side population enriches for leukemia-propagating cell activity and Wnt pathway expression in zebrafish acute lymphoblastic leukemia. Haematologica. 2019 07; 104(7):1388-1395.
PMID: 30630989

Genetic Models of Leukemia in Zebrafish.
Genetic Models of Leukemia in Zebrafish. Front Cell Dev Biol. 2018; 6:115.
PMID: 30294597

An Overview of Hemophagocytic Lymphohistiocytosis.
An Overview of Hemophagocytic Lymphohistiocytosis. Pediatr Ann. 2017 Aug 01; 46(8):e309-e313.
PMID: 28806468

Isolation of the Side Population in Myc-induced T-cell Acute Lymphoblastic Leukemia in Zebrafish.
Isolation of the Side Population in Myc-induced T-cell Acute Lymphoblastic Leukemia in Zebrafish. J Vis Exp. 2017 05 04; (123).
PMID: 28518092

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Regional Top Doctor, Pediatric Hematology-Oncology
Castle Connolly
2013 - now

Pritzker Scholar Award
University of Chicago
2010

Alpha Omega Alpha, Medical Honor Society
University of Wisconsin
1998

Phi Beta Kappa
University of Chicago
1990