Alexander T Pearson, MD PhD

Associate Professor of Medicine
Committee on Cancer Biology
Committee on Clinical Pharmacology and Pharmacogenomics
Committee on Genetics, Genomics and Systems Biology
Clinical Interests: Clinical Trials, Immunotherapy, Medical education, Salivary gland cancers, Squamous Cell Carcinoma Tumors
Research and Scholarly Interests: Artificial Intelligence, Education, Graduate Medical, Head and Neck Cancer, Mathematical Model, Models, Biologic, Neural Network Models, Salivary Gland Cancers, Statistical Models, Therapies, Combined Modality, Tumor Cell Lines, Tumor Immune Escape
Websites: Center for Computational Medicine and Clinical Artificial Intelligence, Pearson Lab, Research Network Profile
Contact: apearson5@uchicago.edu
Graduate Programs: Cancer Biology, Genetics, Genomics & Systems Biology

The Pearson Lab integrates clinical expertise, mathematical modeling, high dimensional statistics, and basic tumor biology methods to investigate and propose new treatments for head and neck cancer.

University of Michigan
Ann Arbor, MI
Fellowship - Hematology/Oncology
2016

University of Michigan
Ann Arbor, MI
Postdoctoral Fellowship - Nor Lab (2013-2017)
2016

University of Michigan
Ann Arbor, MI
Residency - Internal Medicine
2012

University of Rochester
Rochester, NY
MD - Medicine
2010

University of Rochester
Rochester, NY
PhD - Statistics
2009

Cornell University
Ithaca, NY
BS - Biometry and Statistics
2002
Tumor-intrinsic and immune-related features associated with treatment failure in human papillomavirus-related oropharyngeal cancer.
Tumor-intrinsic and immune-related features associated with treatment failure in human papillomavirus-related oropharyngeal cancer. J Natl Cancer Inst. 2025 Mar 11.
PMID: 40069922

Neoadjuvant Nivolumab Plus Chemotherapy Followed by Response-Stratified Chemoradiation Therapy in HPV-Negative Head and Neck Cancer: The DEPEND Phase 2 Nonrandomized Clinical Trial.
Neoadjuvant Nivolumab Plus Chemotherapy Followed by Response-Stratified Chemoradiation Therapy in HPV-Negative Head and Neck Cancer: The DEPEND Phase 2 Nonrandomized Clinical Trial. JAMA Oncol. 2025 Mar 06.
PMID: 40048190

Analysis of AI foundation model features decodes the histopathologic landscape of HPV-positive head and neck squamous cell carcinomas.
Analysis of AI foundation model features decodes the histopathologic landscape of HPV-positive head and neck squamous cell carcinomas. Oral Oncol. 2025 Apr; 163:107207.
PMID: 40043423

End-to-end prediction of clinical outcomes in head and neck squamous cell carcinoma with foundation model-based multiple instance learning.
End-to-end prediction of clinical outcomes in head and neck squamous cell carcinoma with foundation model-based multiple instance learning. medRxiv. 2025 Jan 25.
PMID: 39974018

PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands.
PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands. J Exp Clin Cancer Res. 2025 Jan 11; 44(1):11.
PMID: 39794830

Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology.
Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology. bioRxiv. 2025 Jan 08.
PMID: 39554184

Generative adversarial networks accurately reconstruct pan-cancer histology from pathologic, genomic, and radiographic latent features.
Generative adversarial networks accurately reconstruct pan-cancer histology from pathologic, genomic, and radiographic latent features. Sci Adv. 2024 Nov 15; 10(46):eadq0856.
PMID: 39546597

Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology.
Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology. NPJ Precis Oncol. 2024 Nov 08; 8(1):255.
PMID: 39511421

Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability.
Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability. bioRxiv. 2024 Nov 04.
PMID: 39574723

Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology.
Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology. bioRxiv. 2024 Nov 03.
PMID: 39554184
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Alexander T Pearson, MD PhD

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