Dr. Yu-Ying He leads a research program focused on understanding how normal cells respond to environmental carcinogens and transform into cancerous cells. Her laboratory investigates the roles of epitranscriptomics, epigenetics, and autophagy in maintaining genomic integrity and cellular homeostasis, and how disruptions in these processes contribute to cancer development and therapeutic resistance.
With a particular emphasis on skin cancers—especially squamous cell carcinoma and melanoma—Dr. He’s research aims to uncover the molecular mechanisms that drive tumor initiation, progression, and resistance to treatment. Her long-term goal is to identify previously unrecognized, therapeutically accessible regulatory networks that influence susceptibility to skin cancer. Through this work, Dr. He seeks to advance the prevention and treatment of skin malignancies by providing novel molecular targets and predictive markers for clinical intervention.
Chinese Academy of Sciences
China
PhD - Organic Chemistry
2000
A Comparative Study of Mesenchymal Stem Cell Derived From Human Embryonic Stem Cell-derived Mesenchymal Stem Cells Through a Trophoblast-like Stage and Bone Marrow-derived Mesenchymal Stem Cells in Treating Acute Xenogeneic Graft-versus-host Disease in Humanized Mice.
A Comparative Study of Mesenchymal Stem Cell Derived From Human Embryonic Stem Cell-derived Mesenchymal Stem Cells Through a Trophoblast-like Stage and Bone Marrow-derived Mesenchymal Stem Cells in Treating Acute Xenogeneic Graft-versus-host Disease in Humanized Mice. Transplantation. 2026 Aug 01; 110(8):e1649-e1656.
PMID: 42260632
YTHDF2 regulates self non-coding RNA metabolism to control inflammation and tumorigenesis.
YTHDF2 regulates self non-coding RNA metabolism to control inflammation and tumorigenesis. Nat Commun. 2025 Nov 12; 16(1):9946.
PMID: 41224760
Arsenic regulates ALKBH1 abundance and substrate specificity to promote translation and tumorigenicity.
Arsenic regulates ALKBH1 abundance and substrate specificity to promote translation and tumorigenicity. Cell Rep. 2025 10 28; 44(10):116311.
PMID: 41046516
SSB cooperates with METTL16-mediated m6A RNA methylation to promote chemoresistance in colorectal cancer cells.
SSB cooperates with METTL16-mediated m6A RNA methylation to promote chemoresistance in colorectal cancer cells. Cell Rep. 2025 Jul 22; 44(7):115926.
PMID: 40580478
IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFß.
IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFß. Front Immunol. 2024; 15:1293883.
PMID: 38455057
miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson's disease model via regulation of Nox4/ROS/Nrf2 signaling.
miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson's disease model via regulation of Nox4/ROS/Nrf2 signaling. J Transl Med. 2023 10 24; 21(1):747.
PMID: 37875930
NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity.
NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity. Toxicol Appl Pharmacol. 2023 10 15; 477:116688.
PMID: 37716414
Recent Advances in RNA m6A Modification in Solid Tumors and Tumor Immunity.
Recent Advances in RNA m6A Modification in Solid Tumors and Tumor Immunity. Cancer Treat Res. 2023; 190:95-142.
PMID: 38113000
Surgical Salvage of Annular Rupture After Transcatheter Aortic Valve Implantation by Conversion Into Annular Enlargement.
Surgical Salvage of Annular Rupture After Transcatheter Aortic Valve Implantation by Conversion Into Annular Enlargement. JACC Case Rep. 2022 Nov 16; 4(22):1529-1533.
PMID: 36444183
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis. Nat Commun. 2021 04 12; 12(1):2183.
PMID: 33846348