Raymond E. Moellering

Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics.
Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics. Chem Rev. 2024 Nov 27; 124(22):13020-13093.
PMID: 39540650

Single-cell chemoproteomics identifies metastatic activity signatures in breast cancer.
Single-cell chemoproteomics identifies metastatic activity signatures in breast cancer. Sci Adv. 2024 Oct 25; 10(43):eadp2622.
PMID: 39441940

Family-Wide Photoproximity Profiling of Integrin Protein Social Networks in Cancer.
Family-Wide Photoproximity Profiling of Integrin Protein Social Networks in Cancer. bioRxiv. 2024 Sep 22.
PMID: 39345550

Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors.
Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors. Nat Chem Biol. 2025 Feb; 21(2):247-255.
PMID: 39215099

PARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function.
PARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function. Biochemistry. 2023 11 07; 62(21):3126-3133.
PMID: 37884446

LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma. Cancer Discov. 2023 04 03; 13(4):1002-1025.
PMID: 36715544

Spatial Chemoproteomics for Mapping the Active Proteome.
Spatial Chemoproteomics for Mapping the Active Proteome. Isr J Chem. 2023 Mar; 63(3-4).
PMID: 38046285

Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function.
Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function. ACS Chem Biol. 2023 01 20; 18(1):91-101.
PMID: 36562291

Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains.
Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Nat Biotechnol. 2023 04; 41(4):541-551.
PMID: 36302987

SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells.
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells. mBio. 2022 10 26; 13(5):e0241522.
PMID: 36125275