Dr. Faubert leads a research laboratory focused on understanding how metabolic reprogramming—alterations in metabolic flux within malignant cells—supports cancer cell survival, growth, and progression. The Faubert lab has extensive expertise in both in vitro and in vivo metabolic analysis, including the direct measurement of tumor metabolism intra-operatively in patients.
To achieve a comprehensive understanding of metabolic pathways in cancer, Dr. Faubert's team employs a wide array of mass spectrometry platforms alongside advanced methodologies such as isotope tracing (^13C, ^2H, etc.), metabolomics, and metabolic flux analysis. These tools allow the lab to dissect the metabolic programs driving malignant phenotypes at both cellular and systemic levels.
Complementing these biochemical techniques, the lab also uses molecular imaging technologies to noninvasively monitor tumor metabolic states in vivo. This dual approach enables the investigation of metabolic heterogeneity across different tumor types and stages. Recent work from Dr. Faubert’s laboratory is exploring the metabolic alterations that occur during the metastatic cascade, aiming to uncover novel vulnerabilities that can be therapeutically targeted.
Brandon Faubert, PhD
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Assistant Professor of Medicine
Committee on Cancer Biology
Committee on Molecular Metabolism and Nutrition - Research and Scholarly Interests: Cancer Metabolism, In Vivo Metabolism, Lung Cancer, Mass Spectrometry, Metastasis, Stable Isotope Tracing
- Websites: Google Scholar, Lab Website, Research Network Profile
- Contact: bfaubert@uchicago.edu
- Graduate Programs: Cancer Biology, Molecular Metabolism and Nutrition, UChicago Biosciences