Exploring stapled peptides as a tool for interrupting protein-protein interactions in order to manipulate the immune system with the overall goal of improving existing immunotherapies and generating new strategies for the treatment of cancer.
Studying the glycolysis-NRF2 pathway to find: 1. Determinates of viability among different cancer contexts 2. How to exploit targeting of central glycolysis alone or in combination. 3. How cells with rewired metabolism adapt redox for their advantage.
Investigating the effects of BCL-2 blockade on regulatory T cell function and survival. My goal is to modulate Treg function for the benefit of either cancer immunotherapy or alleviation of autoimmune diseases.